Predictive testing for hereditary non-polyposis colorectal cancer: motivation, illness representations and short-term psychological impact

2004 ◽  
Vol 55 (2) ◽  
pp. 265-274 ◽  
Author(s):  
Erna Claes ◽  
Lieve Denayer ◽  
Gerry Evers-Kiebooms ◽  
Andrea Boogaerts ◽  
Eric Legius
Keyword(s):  
Colorectal Cancer ◽  
Psychological Impact ◽  
Predictive Testing ◽  
Illness Representations ◽  
Short Term

scholarly journals Persuasion, Adaptation, and Double Identity: Qualitative Study on the Psychological Impact of a Screen-Detected Colorectal Cancer Diagnosis

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Lesley M. McGregor ◽  
Sara Tookey ◽  
Rosalind Raine ◽  
Christian von Wagner ◽  
Georgia Black
Keyword(s):  
Colorectal Cancer ◽  
Screening Programme ◽  
Psychological Impact ◽  
Healthy Population ◽  
Short Term ◽  
Interview Method ◽  
Diagnostic Pathway ◽  
Narrative Interview ◽  
Cancer Screening Programme ◽  
Bowel Cancer Screening

The NHS Bowel Cancer Screening Programme (BCSP) is aimed at reducing colorectal cancer (CRC) mortality through early detection within a healthy population. This study explores how 5 people (three females) experience and make sense of their screen-detected diagnosis and the psychological implications of this diagnostic pathway. A biographical narrative interview method was used, and transcripts were analysed using a thematic analysis with a phenomenological lens. Themes specifically relating to posttreatment experience and reflections are reported here: Do it: being living proof, Resisting the threat of recurrence, Rationalising bodily change, and Continuing life—“carrying on normally.” Participants described their gratefulness to the BCSP, motivating a strong desire to persuade others to be screened. Furthermore, participants professed a duality of experience categorised by the normalisation of life after diagnosis and treatment and an identification of strength post cancer, as well as a difficulty adjusting to the new changes in life and a contrasting identity of frailty. Understanding both the long- and short-term impacts of a CRC diagnosis through screening is instrumental to the optimisation of support for patients. The results perhaps highlight a particular target for psychological distress reduction, which could reduce the direct and indirect cost of cancer to the patient.

Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

2019 ◽  
Vol 26 (7) ◽  
pp. 512-522
Author(s):  
Xian Li ◽  
Long Xia ◽  
Xiaohui Ouyang ◽  
Qimuge Suyila ◽  
Liya Su ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Nude Mice ◽  
Low Dose ◽  
Bioactive Peptides ◽  
Human Colorectal Cancer ◽  
Short Term ◽  
Hct 116

<P>Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. </P><P> Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. </P><P> Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. </P><P> Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. </P><P> Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.</P>

Short term outcome for colorectal cancer patients undergoing surgery in Tertiary care center in Eastern India

2021 ◽  
Vol 47 (2) ◽  
pp. e50-e51
Author(s):  
Abhitesh Singh ◽  
Anshul Jain ◽  
Dillip Muduly ◽  
Mahesh Sultania ◽  
Jyoti Ranjan Swain ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Eastern India ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Colorectal Cancer Patients

scholarly journals Short‐term outcomes of a COVID‐adapted triage pathway for colorectal cancer detection

2021 ◽  
Author(s):  
Janice Miller ◽  
Yasuko Maeda ◽  
Stephanie Au ◽  
Frances Gunn ◽  
Lorna Porteous ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Detection ◽  
Short Term

‘When that great ship went down’: Modern maritime disasters and collective memory

2014 ◽  
Vol 26 (4) ◽  
pp. 734-751
Author(s):  
Robert C. Moyer
Keyword(s):  
Collective Memory ◽  
Psychological Impact ◽  
Research Approach ◽  
Short Term ◽  
Qualitative Comparison ◽  
Indirect Measurements ◽  
Internet Media ◽  
The Social ◽  
Air Disaster

The aim of this article is to examine the social and psychological impact of modern maritime disasters upon the population of a technologically developed nation. Through an innovative research approach using various indirect measurements of public interest including the internet, media response, music and film, the article explores the interest displayed by the American public following the loss of ships such as the Titanic, Andrea Doria, Edmund Fitzgerald, and Andrea Gail. In order to provide a basis for qualitative comparison, disasters involving other modes of transportation are also considered, including the Hindenburg crash, the ‘Great Train Wreck of 1918’ in Nashville, TN, the Tenerife air disaster of 1977, and the Concorde crash of 2000. The article seeks to explain why the American public seems to display more short-term and long-term interest in maritime disasters than in disasters involving other forms of transportation.

Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer

2009 ◽  
Vol 96 (12) ◽  
pp. 1458-1467 ◽  
Author(s):  
J. Neudecker ◽  
F. Klein ◽  
R. Bittner ◽  
T. Carus ◽  
A. Stroux ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Randomized Trial ◽  
Open Surgery ◽  
Prospective Randomized Trial ◽  
Short Term
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