Diabetes mellitus and risk of pancreatic cancer in China: A meta-analysis based on 26 case-control studies

2019 ◽  
Vol 13 (3) ◽  
pp. 276-282 ◽  
Author(s):  
Ji-Jun Zhang ◽  
Jie-peng Jia ◽  
Quan Shao ◽  
Ying-kai Wang
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Su1836 Gastrectomy Is Not a Risk Factor for Pancreatic Cancer: A Meta-Analysis of Case-Control Studies

2014 ◽  
Vol 146 (5) ◽  
pp. S-1048-S-1049
Author(s):  
Rajan Kanth ◽  
Naga Swetha Samji ◽  
Ramon E. Rivera ◽  
Mainor R. Antillon ◽  
Praveen K. Roy
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Association of Helicobacter pylori infection with diabetes mellitus: A Meta-analysis of Case Control Studies

2019 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Analysis Study ◽  
Geographical Regions ◽  
H Pylori

Abstract Background Results of previous studies were showed that the association between H. pylori infection and the risk of diabetes is still controversies. Therefore, this systematic review and meta-analysis study was designed and implemented aimed to determine the association between H. pylori infection and the risk of diabetes.Methods All case control articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to March 2019 without language limitations. Also, logarithm and standard error logarithm odds ratio (OR) were used for meta-analysis.Results A total of 41 studies were included in this meta-analysis. The range of association with odds ratio in case control studies which published between 1990 to 2019 was 0.21 to 6.08. The pooled estimate of the association between H. pylori infection with diabetes was 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus, type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was higher than other population, but in the American, this was a protective relationship.Conclusion In conclusion, this systematic review & meta-analysis study suggested that H. pylori infection was associated with the risk of diabetes as compared to non- diabetes individual.

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

2021 ◽  
Vol 53 (05) ◽  
pp. 293-300
Author(s):  
Rui Wang ◽  
Hongyan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Lower Serum ◽  
Matched Case

AbstractIrisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes’ Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48–1.77, p<0.001; I2=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93–2.79, p<0.001; I2=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microalbuminuria (10 studies, SMD: 0.91, 95% CI: 0.44–1.38, p<0.001; I2=90%). In addition, patients with estimated glomerular infiltration rate (eGFR)<60 ml/min 1.73 m2 had lower serum irisin compared to those with eGFR≥60 ml/min 1.73 m2 (4 studies, SMD: 0.89, 95% CI: 0.32–1.46, p=0.002; I2=91%). In conclusion, serum irisin may be associated with albuminuria and reduced eGFR in T2DM patients.

scholarly journals The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Li Li ◽  
Xuesong Gai
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Publication Bias ◽  
Meta Analysis ◽  
Case Control ◽  
Significant Heterogeneity ◽  
Case Control Studies ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Pancreatic Cancer Risk

Previous reports have suggested a potential association on dietary zinc intake with the risk of pancreatic cancer. Since the associations between different studies were controversial, we therefore conducted a meta-analysis to reassess the relationship between dietary zinc intake and pancreatic cancer risk. A comprehensive search from the databases of PubMed, Embase, Web of Science, and Medline was performed until January 31, 2017. Relative risk (RR) with 95% confidence intervals (CI) derived by using random effect model was used. Sensitivity analysis and publication bias were conducted. Our meta-analysis was based on seven studies involving 1659 cases, including two prospective cohort studies and five case–control studies. The total RR of pancreatic cancer risk for the highest versus the lowest categories of dietary zinc intake was 0.798 (0.621–0.984), with its significant heterogeneity among studies (I2=58.2%, P=0.026). The average Newcastle–Ottawa scale (NOS) score was 7.29, suggesting a high quality. There was no publication bias in the meta-analysis about dietary zinc intake on the risk of pancreatic cancer. Subgroup analyses showed that dietary zinc intake could reduce the risk of pancreatic cancer in case–control studies and among American populations. In conclusion, we found that highest category of dietary zinc intake can significantly reduce the risk of pancreatic cancer, especially among American populations.

scholarly journals Helicobacter pylori infection as a risk factor for diabetes: A Meta-analysis of Case-Control Studies

2020 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Geographical Regions ◽  
H Pylori ◽  
And Control

Abstract Background There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. Methods A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990–March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case–control studies were analyzed using odds ratio (OR) with 95 % confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis. Results A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR=1.27 (95% CI 1.11 to 1.45, P = 0.0001, I2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population.Conclusion In overall a positive association between H. pyloriinfection and diabetes mellitus was found.

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