Socioeconomic position and cardiovascular risk factors among people with screen-detected Type 2 DM: Six-year follow-up of the ADDITION-Denmark trial

2014 ◽  
Vol 8 (4) ◽  
pp. 322-329 ◽  
Author(s):  
Else-Marie Dalsgaard ◽  
Mogens Vestergaard ◽  
Mette Vinther Skriver ◽  
Knut Borch-Johnsen ◽  
Torsten Lauritzen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Socioeconomic Position ◽  
Type 2 Dm

P3647Spontaneous coronary artery dissection: new insights on presentation, clinical and angiographic characteristics from the French multicenter registry DISCO study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Bouajila ◽  
N Combaret ◽  
G Souteyrand ◽  
C Spaulding ◽  
H Benamer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Intramural Hematoma ◽  
Stress Factors ◽  
Artery Dissection ◽  
Coronary Artery Dissection

Abstract Background Spontaneous coronary artery dissection (SCAD) is an underdiagnosed and poorly understood cause of acute coronary syndrome (ACS). Clinical, angiographic features and management remain to be better defined in large cohorts. Purpose The aim of this study was to evaluate clinical, angiographic characteristics, treatment modalities and prognosis of patients with SCAD from a multicenter national registry. Methods From 2016 to 2018, SCAD patients were enrolled retrospectively and prospectively in the French multicenter regristry DISCO study in 61 cardiology interventional centers. All coronary angiograms were reviewed by 2 experienced cardiologists for diagnosis confirmation and classified according to current angiographic SCAD classification. Results A total of 373 confirmed SCAD patients were included, 45.6% prospectively, 54.4% retrospectively. Mean age was 51.5±10.3 years, with 90.6% women of whom 51.2% were postmenauposal. Ninety percent of patients had ≤2 cardiovascular risk factors, 96.2% presented with ACS, with a positive troponin in 95.4%, and ST-segment elevation in 45.0%. Precipitating emotional stress factors were reported in 46.0% and a physical trigger in 12.4%. Systemic inflammatory disease was present in 5 patients (1.4%). Peripartum SCAD accounted for only 4.4% of cases. The majority of patients (75.1%) had type 2 angiographic SCAD (diffuse long smooth tubular lesions due to intramural hematoma), with only 13.8% and 8.9% having type 1 (longitudinal filling defect) and type 3 (multiple focal tubular lesions due to intramural hematoma) respectively. Multivessel SCAD occurred in 6.2%. While 84.2% of SCAD patients were initially treated conservatively, 15.5% underwent percutaneous coronary intervention as the initial strategy and 1 patient (0.3%) required surgical implantation of a left ventricular assist device. Repeat angiogram was conducted in 288 patients (median 38 [8–70] days) showing improvement of the culprit lesion in 81.9%. At 1 year follow-up, recurrent SCAD occurred in 2.5%, major adverse cardiac events (stroke, myocardial infarction, and revascularization) in 7.7%, and all patients survived. Conclusion Our study confirms that SCAD predominantly affects early middle-aged women with few cardiovascular risk factors, with peripartum SCAD accounting for a minority of cases. Type 2 angiographic SCAD which is difficult to recognize was the most frequent angiographic appearance. This may contribute to the underestimation of SCAD in clinical practice. The majority of patients were treated conservatively with favorable outcomes. Longer-term follow-up of this large cohort and further investigations on physiopathology are warranted to improve management and risk stratification of patients. Acknowledgement/Funding Fondation Coeur et Recherche, French Coronary Atheroma and Interventional Cardiology Group, French Society of Cardiology

Abstract P498: Association of Steps Per Day With Diabetes, Hypertension, and Obesity Over 10 Years: Results From the Coronary Artery Risk Development in Young Adults Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Amanda E Paluch ◽  
Kelley Pettee Gabriel ◽  
Janet E Fulton ◽  
Juned Siddique ◽  
Kara M Whitaker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Lower Risk ◽  
Cox Models ◽  
Step Counts ◽  
Steps Per Day

Introduction: Step counts are an easy way for individuals to quantify their physical activity; there is limited data relating accelerometer-derived step counts with the onset of cardiovascular risk factors. We hypothesized that steps/day are inversely associated with type 2 diabetes, stage 2 hypertension, and obesity 10 years later. Methods: Data are from 1,923 CARDIA study participants with valid (≥4 days with ≥10 hours/day) accelerometer wear (ActiGraph 7164) in 2005-2006 with at least one follow-up visit 5- or 10- years later. Multivariable Cox models calculated hazard ratios (HR) and 95% confidence intervals (CI) for incidence of type 2 diabetes, stage 2 hypertension, and obesity. Results: The analytic sample (45.3±3.6 years; 58% women, 41% black) had a mean follow-up of 9.7±1.3 years. After adjusting for demographics and lifestyle characteristics, every 1000 higher steps/day was associated with a 10% lower risk of diabetes and 5% lower risk of hypertension. When adding comorbidities to the model, the HRs were slightly attenuated, and remained significant for diabetes [0.93 (95% CI, 0.87-0.99)]. Compared to the lowest step quartile, the highest quartile was at a 43% lower risk of diabetes and a 31% lower risk of hypertension. When testing for interactions by race or sex, the only significant interaction was for sex with obesity as the outcome. Steps were only associated with obesity in women, where every 1000 higher steps/day were associated with a 13% lower risk, and the highest quartile was 61% less likely to develop obesity compared to the lowest quartile. Conclusions: Among middle age adults, accumulating a higher volume of steps/day was associated with a lower risk of type 2 diabetes and stage 2 hypertension. In women, higher steps/day was associated with lower risk of obesity. Encouraging the accumulation of steps/day may be an effective public health strategy to lower the burden of cardiovascular risk factors.

P 30: Cardiovascular risk factors in type 2 diabetes along 3 years of follow-up

2012 ◽  
Vol 38 ◽  
pp. S115
Author(s):  
F. Arrieta ◽  
M. Piñera ◽  
P. Nogales ◽  
R. Iglesias ◽  
E. Tutor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors
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