Managing type 2 diabetes in Soweto—The South African Chronic Disease Outreach Program experience

2009 ◽  
Vol 3 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Ivor Katz ◽  
Helen Schneider ◽  
Zodwa Shezi ◽  
Golebemang Mdleleni ◽  
Trevor Gerntholtz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Disease ◽  
South African ◽  
Outreach Program ◽  
The South

Willingness of people with Type 2 diabetes to start insulin therapy: Evidence from the South African Tshwane Insulin Project (TIP)

2020 ◽  
Vol 168 ◽  
pp. 108366
Author(s):  
Patrick Ngassa Piotie ◽  
Paola Wood ◽  
Elizabeth M. Webb ◽  
Tessa S. Marcus ◽  
Paul Rheeder
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
South African ◽  
The South

scholarly journals Antigenicity and Immunogenicity Analysis of the E. coli Expressed FMDV Structural Proteins; VP1, VP0, VP3 of the South African Territories Type 2 Virus

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1005
Author(s):  
Guoxiu Li ◽  
Ashenafi Kiros Wubshet ◽  
Yaozhong Ding ◽  
Qian Li ◽  
Junfei Dai ◽  
...  
Keyword(s):  
South African ◽  
Recombinant Proteins ◽  
Fusion Proteins ◽  
Serum Antibody ◽  
Vaccine Design ◽  
Structural Proteins ◽  
The South ◽  
Study Results ◽  
Mouth Disease Virus

An alternative vaccine design approach and diagnostic kits are highly required against the anticipated pandemicity caused by the South African Territories type 2 (SAT2) Foot and Mouth Disease Virus (FMDV). However, the distinct antigenicity and immunogenicity of VP1, VP0, and VP3 of FMDV serotype SAT2 are poorly understood. Similarly, the particular roles of the three structural proteins in novel vaccine design and development remain unexplained. We therefore constructed VP1, VP0, and VP3 encoding gene (SAT2:JX014256 strain) separately fused with His-SUMO (histidine-small ubiquitin-related modifier) inserted into pET-32a cassette to express the three recombinant proteins and separately evaluated their antigenicity and immunogenicity in mice. The fusion protein was successfully expressed and purified by the Ni-NTA resin chromatography. The level of serum antibody, spleen lymphocyte proliferation, and cytokines against the three distinct recombinant proteins were analyzed. Results showed that the anti-FMDV humoral response was triggered by these proteins, and the fusion proteins did enhance the splenocyte immune response in the separately immunized mice. We observed low variations among the three fusion proteins in terms of the antibody and cytokine production in mice. Hence, in this study, results demonstrated that the structural proteins of SAT2 FMDV could be used for the development of immunodiagnostic kits and subunit vaccine designs.

scholarly journals Management of Chronic Disease and Hospitalization Due to Diabetes among Type 2 Diabetes Patients in Korea: Using the National Sample Cohort Data 2002–2013

2018 ◽  
Vol 15 (11) ◽  
pp. 2541
Author(s):  
Sang Lee ◽  
Woorim Kim ◽  
Sarah Oh ◽  
Jieun Yang ◽  
Jieun Jang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Disease ◽  
National Sample ◽  
Self Management ◽  
Management Skills ◽  
Cohort Data ◽  
Onset Of Diabetes ◽  
Cox Proportional Hazard Regression ◽  
Diabetes Patients

To prevent negative outcomes for diabetes patients, developing self-management skills is imperative. This study aimed to examine the association between management of chronic disease (MCD), which mainly involves educating patients about their chronic diseases for obtaining self-management skills and hospitalization due to diabetes among type 2 diabetes patients in Korea. Korean National Health Insurance Service National Sample Cohort data from 2002 to 2013 were used. A total of 54,031 type 2 diabetes patients were included in the study. If patients received the MCD within 1 year from the onset of diabetes, we categorized them as “MCD received patients” We reclassified these groups into five groups: “non-receiving”, “1–3 times”, “4–6 times”, “7–9 times” and “10–12 times” The dependent variable of this study was hospitalization due to diabetes. Cox proportional hazard regression was used. Of the patients, 86.2% (n = 46,571) did not received the MCD within the 1 year from the onset of diabetes. The number of MCDs received increased and the hazard ratio (HR) for hospitalization due to diabetes decreased; particularly, patients who received MCD 10–12 times per annum showed the lowest HR for hospitalization due to diabetes compared to patients in the MCD non-received group (1–3 times per annum: HR: 0.81, p = 0.0001; 4–6 times per annum: HR: 0.82, p = 0.0248; 7–9 times per annum: HR: 0.75, p = 0.0054; 10–12 times per annum: HR: 0.61, p < 0.0001). Considering the importance of raising self-managing diabetes skills, the findings can aid in determining the outcomes of the MCD program.

scholarly journals The development of multimorbidity during 16 years after diagnosis of type 2 diabetes

2018 ◽  
Vol 8 (1) ◽  
pp. 2235042X1880165 ◽  
Author(s):  
Sandra Pouplier ◽  
Maria Åhlander Olsen ◽  
Tora Grauers Willadsen ◽  
Håkon Sandholdt ◽  
Volkert Siersma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Disease ◽  
Diabetes Care ◽  
Cox Regression ◽  
Neurological Diseases ◽  
Gastrointestinal Diseases ◽  
Diabetes Diagnosis ◽  
Prevalent Disease ◽  
Diabetes Patients

Objective: The aims of this study were to (1) quantify the development and composition of multimorbidity (MM) during 16 years following the diagnosis of type 2 diabetes and (2) evaluate whether the effectiveness of structured personal diabetes care differed between patients with and without MM. Research design and methods: One thousand three hundred eighty-one patients with newly diagnosed type 2 diabetes were randomized to receive either structured personal diabetes care or routine diabetes care. Patients were followed up for 19 years in Danish nationwide registries for the occurrence of outcomes. We analyzed the prevalence and degree of MM based on 10 well-defined disease groups. The effect of structured personal care in diabetes patients with and without MM was analyzed with Cox regression models. Results: The proportion of patients with MM increased from 31.6% at diabetes diagnosis to 80.4% after 16 years. The proportion of cardiovascular and gastrointestinal diseases in surviving patients decreased, while, for example, musculoskeletal, eye, and neurological diseases increased. The effect of the intervention was not different between type 2 diabetes patients with or without coexisting chronic disease. Conclusions: In general, the proportion of patients with MM increased after diabetes diagnosis, but the composition of chronic disease changed during the 16 years. We found cardiovascular and musculoskeletal disease to be the most prevalent disease groups during all 16 years of follow-up. The post hoc analysis of the intervention showed that its effectiveness was not different among patients who developed MM compared to those who continued to have diabetes alone.

scholarly journals Poor glycemic control in type 2 diabetes in the South of the Sahara: The issue of limited access to an HbA1c test

2015 ◽  
Vol 108 (1) ◽  
pp. 187-192 ◽  
Author(s):  
Alioune Camara ◽  
Naby M. Baldé ◽  
Joelle Sobngwi-Tambekou ◽  
André P. Kengne ◽  
Mansour M. Diallo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Poor Glycemic Control ◽  
The South ◽  
Limited Access ◽  
Hba1c Test
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