Male rats with same-sex preference show higher immobility in the forced swim test, but similar effects of fluoxetine and desipramine than males that prefer females

2018 ◽  
Vol 171 ◽  
pp. 39-45 ◽  
Author(s):  
Alejandra Hernández ◽  
Alonso Fernández-Guasti
Keyword(s):  
Forced Swim Test ◽  
Male Rats ◽  
Same Sex ◽  
Swim Test ◽  
Sex Preference ◽  
Forced Swim

scholarly journals Study of the Role of Dopamine Receptors in Streptozotocin-Induced Depressive-Like Behavior Using the Forced Swim Test Model

2017 ◽  
Vol 7 ◽  
pp. e954
Author(s):  
Afshin Roostaei ◽  
Gholamhassan Vaezi ◽  
Mohammad Nasehi ◽  
Ali Haeri-Rohani ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Receptor Antagonist ◽  
Dopamine Receptors ◽  
Dopamine Receptor ◽  
Forced Swim Test ◽  
Male Rats ◽  
Test Model ◽  
Dopamine Receptor Antagonist ◽  
Swim Test ◽  
Forced Swim

Background: Diabetes is one of the most common endocrine diseases characterized by hyperglycemia. It is caused by an absolute or relative insulin deficiency or an insulin function deficiency. It is one of the major risk factors of depression, with the rate of depression in diabetic patients amounting to as high as 30%. This study examined the role of dopamine receptors in streptozotocin (STZ)-induced depressive-like behavior using the forced swim test (FST). Materials and Methods: This study was performed on 56 Wistar male rats. STZ at doses of 30 and 60 mg/kg body weight was administered via intraperitoneal (IP) route to induce diabetes and depression in rats. Thereafter, by using halobenzazepine (SCH23390) (D1 dopamine receptor antagonist) and sulpiride (D2 receptor dopamine receptor antagonist), the role of dopamine receptors in STZ-induced depression was studied. The one-way analysis of variance technique, Tukey’s range test, and t-test were used to analyze the data. The P-value less than 0.05 was regarded as statistically significant. Results: Our study showed that STZ at doses of 30 and 60 mg/kg, two weeks after injection, caused prolonged immobility in FST, indicating depressive-like behavior (P<0.05 and P<0.01, respectively). SCH23390 (0.001 mg/mL/kg) and sulpiride (0.1mg/mL/kg) did not change the variables of depression in animals that received STZ (at doses of 30 and 60 mg/mL/kg) two weeks before (P>0.05). Conclusion: According to our study, STZ has a depressive-like behavior two weeks after injection, and dopamine receptors do not play a role in depression associated with STZ use. [GMJ.2018;7:e954]

Dapagliflozin attenuates depressive-like behavior of male rats in the forced swim test

2018 ◽  
Author(s):  
Cam Muhammet Emin ◽  
Ayşe Nur Hazar-Yavuz ◽  
Yildiz Sila ◽  
Rumeysa Keles ◽  
Ertaş Büşra
Keyword(s):  
Forced Swim Test ◽  
Male Rats ◽  
Swim Test ◽  
Forced Swim

Investigation of Diagnostic Proteins by 2D Electrophoresis in Major De-pression Model Induced by Forced Swim Test in Rats.

2020 ◽  
Vol 27 ◽  
Author(s):  
Tuğçe Duman ◽  
Enes Akyüz ◽  
Huri Bulut ◽  
Abdurrahim Koçyiğit ◽  
Ahmet Tülek ◽  
...  
Keyword(s):  
Forced Swim Test ◽  
Diagnostic System ◽  
Economic Consequences ◽  
Male Rats ◽  
2D Electrophoresis ◽  
Serum Samples ◽  
Swim Test ◽  
Forced Swim ◽  
Potential Biomarker ◽  
The Matrix

Background: Aside from its pervasiveness, whereby it affects as much as 20% of the world's population, depression continues to be one of the most crucial psychiatric problems due to the loss of power it causes by disrupting daily life functioning, containing economic consequences, and having a high suicidal tendency. Major depression (MD) is a systemic and multifactorial disorder involving complex interactions between genetic predisposition and disturbances of various molecular pathways. Objectives: In our current study, we aimed to identify the proteins obtained from serum samples that change during depression with the MD model. Methods : The MD model was applied through the forced swim test in rats. 14 Winstar Albino male rats were divided into two equal groupsas follows: depression and control groups. Serum samples were separated by chromatographic methods and then compared with two-dimensional (2D) electrophoresis. Results: A total of 9 potential diagnostic protein sequences were identified, which were distinguished with computer soft-ware. During the last phase of the study,the Matrix-Assisted Laser Desorption/Ionization –Time of Flight (MALDI-TOF) analysis, the previous expression sequences identified among the groups were determinedand classified. By comparing pro-tein expressions, it was concluded that 9 different points could be used together as a potential biomarker. Conclusion: Results can help us identify a new diagnostic system that can be used to diagnose MD.

scholarly journals Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0131709 ◽  
Author(s):  
David L. Arndt ◽  
Christy J. Peterson ◽  
Mary E. Cain
Keyword(s):  
Weight Gain ◽  
Forced Swim Test ◽  
Test Weight ◽  
Male Rats ◽  
Swim Test ◽  
Forced Swim ◽  
Post Test ◽  
Test Behavior

scholarly journals Decreased serotonin content and release in the ventral hippocampus of prenatally stressed male rats in response to forced swim test

2020 ◽  
Vol 80 (4) ◽  
pp. 331-343
Author(s):  
Felipe de Jesús Jiménez Vásquez ◽  
Diana Méndez Guerrero ◽  
Moisés Rubio Osornio ◽  
María del Carmen Rubio Osornio ◽  
Sandra Orozco Suárez ◽  
...  
Keyword(s):  
Forced Swim Test ◽  
Ventral Hippocampus ◽  
Male Rats ◽  
Serotonin Content ◽  
Swim Test ◽  
Forced Swim ◽  
Prenatally Stressed

Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test

1991 ◽  
Vol 39 (2) ◽  
pp. 373-377 ◽  
Author(s):  
A. Armario ◽  
M. Gil ◽  
J. Marti ◽  
O. Pol ◽  
J. Balasch
Keyword(s):  
Adult Male ◽  
Forced Swim Test ◽  
Male Rats ◽  
Swim Test ◽  
Forced Swim

Dapagliflozin attenuates depressive-like behavior of male rats in the forced swim test

2019 ◽  
Vol 29 ◽  
pp. S262-S263
Author(s):  
M.E. Cam ◽  
A.N. Hazar-Yavuz ◽  
S. Yildiz ◽  
R. Keles ◽  
B. Ertas ◽  
...  
Keyword(s):  
Forced Swim Test ◽  
Male Rats ◽  
Swim Test ◽  
Forced Swim

Attenuating effects of testosterone on depressive-like behavior in the forced swim test in healthy male rats

2009 ◽  
Vol 79 (3-4) ◽  
pp. 182-186 ◽  
Author(s):  
T.E. Buddenberg ◽  
M. Komorowski ◽  
L.A. Ruocco ◽  
M.A. de Souza Silva ◽  
B. Topic
Keyword(s):  
Forced Swim Test ◽  
Male Rats ◽  
Healthy Male ◽  
Swim Test ◽  
Forced Swim

scholarly journals The Forced Swim Test as a Model of Depressive-like Behavior

10.3791/52587 ◽  
2015 ◽  
Author(s):  
Roni Yankelevitch-Yahav ◽  
Motty Franko ◽  
Avrham Huly ◽  
Ravid Doron
Keyword(s):  
Forced Swim Test ◽  
Swim Test ◽  
Forced Swim
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