Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression

2017 ◽  
Vol 158 ◽  
pp. 32-38 ◽  
Author(s):  
Yuan Du ◽  
Haiyue Liang ◽  
Leiming Zhang ◽  
Fenghua Fu
Keyword(s):  
Rat Model ◽  
Huperzine A ◽  
Post Stroke ◽  
Post Stroke Depression

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model

2019 ◽  
Vol 41 (5) ◽  
pp. 446-455 ◽  
Author(s):  
Ming-zhe Hu ◽  
An-rong Wang ◽  
Ze-yu Zhao ◽  
Xiang-yan Chen ◽  
Yan-bin Li ◽  
...  
Keyword(s):  
Rat Model ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Decreased expression of neuronal Per-Arnt-Sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model

2014 ◽  
Vol 7 (4) ◽  
pp. 1045-1049 ◽  
Author(s):  
ZHAOHUI ZHANG ◽  
PENGGE FEI ◽  
JUNLIN MU ◽  
HAOLIANG WANG ◽  
WENQIANG LI ◽  
...  
Keyword(s):  
Rat Model ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Domain Protein

scholarly journals Study on the behavioral changes of a post-stroke depression rat model

2015 ◽  
Vol 10 (1) ◽  
pp. 159-163 ◽  
Author(s):  
CHUNFANG WU ◽  
JUNHE ZHANG ◽  
YONG CHEN
Keyword(s):  
Rat Model ◽  
Behavioral Changes ◽  
Post Stroke ◽  
Post Stroke Depression

CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression

2021 ◽  
Author(s):  
Xiaoli Hou ◽  
Huanhuan Liu ◽  
Yukun Ping ◽  
Feng Zhang ◽  
Lingyun Zhi ◽  
...  
Keyword(s):  
Rat Model ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Aimei Zhao ◽  
Bo Ma ◽  
Li Xu ◽  
Mingjiang Yao ◽  
Yehao Zhang ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Rat Model ◽  
Molecular Mechanisms ◽  
Oral Treatment ◽  
Vital Role ◽  
Depression Symptoms ◽  
Neural Function ◽  
Gamma Aminobutyric Acid ◽  
Post Stroke ◽  
Post Stroke Depression

Post-stroke depression (PSD) is one of the most common stroke complications, which seriously affects stroke’s therapeutic effect and brings great pain for patients. The pathological mechanism of PSD has not been revealed. Jiedu Tongluo granules (JDTLG) is an effective traditional Chinese medicine for PSD treatment which is widely used in clinical treatment. JDTLG has a significant therapeutic effect against PSD, but the mechanism is still unclear. The PSD rat model was established by carotid artery embolization combined with chronic sleep deprivation followed by treating with JDTLG. Neurobehavioral and neurofunctional experiments were engaged in studying the neural function of rats. Histomorphology, proteomics, and western blotting researches were performed to investigate the potential molecular mechanisms related to JDTLG therapy. Oral treatment of JDTLG could significantly improve the symptoms of neurological deficit and depression symptoms of PSD rats. Proteomic analysis identified several processes that may involve the regulation of JDTLG on the PSD animal model, including energy metabolism, nervous system, and N-methyl-D-aspartate receptor (NMDAR)/brain-derived neurotrophic factor (BDNF) signal pathway. Our results showed that JDTLG could reduce glutamate (Glu) level and increase gamma-aminobutyric acid (GABA) level via regulating the NMDAR/BDNF pathway, which may play a vital role in the occurrence and development of PSD.

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