scholarly journals Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats

2015 ◽  
Vol 130 ◽  
pp. 22-33 ◽  
Author(s):  
Patricia J. Allen ◽  
Joseph F. DeBold ◽  
Maribel Rios ◽  
Robin B. Kanarek
Keyword(s):  
Gene Expression ◽  
Sex Hormone ◽  
Female Rats ◽  
High Dose ◽  
Related Gene ◽  
Male And Female ◽  
Male And Female Rats ◽  
Opposing Effects ◽  
And Behavior

scholarly journals Analysis of structure and gene expression in developing kidneys of male and female rats exposed to low protein diets in utero

2020 ◽  
Vol 303 (10) ◽  
pp. 2657-2667 ◽  
Author(s):  
Ryan J. Wood‐Bradley ◽  
Sarah L. Henry ◽  
Sanna Barrand ◽  
Anais Giot ◽  
Luke Eipper ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Utero ◽  
Female Rats ◽  
Male And Female ◽  
Low Protein ◽  
Male And Female Rats ◽  
Protein Diets

scholarly journals Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats

BMC Genomics ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Cynthia A. Kelm-Nelson ◽  
Stephen Gammie
Keyword(s):  
Gene Expression ◽  
Early Onset ◽  
Early Stage ◽  
Protein Localization ◽  
Periaqueductal Gray ◽  
Female Rats ◽  
Vocal Behavior ◽  
Metabotropic Receptors ◽  
Male And Female ◽  
Male And Female Rats

Abstract Background Parkinson’s disease (PD) is a degenerative disease with early-stage pathology hypothesized to manifest in brainstem regions. Vocal deficits, including soft, monotone speech, result in significant clinical and quality of life issues and are present in 90% of PD patients; yet the underlying pathology mediating these significant voice deficits is unknown. The Pink1−/− rat is a valid model of early-onset PD that presents with analogous vocal communication deficits. Previous work shows abnormal α-synuclein protein aggregation in the periaqueductal gray (PAG), a brain region critical and necessary to the modulation of mammalian vocal behavior. In this study, we used high-throughput RNA sequencing to examine gene expression within the PAG of both male and female Pink1−/− rats as compared to age-matched wildtype controls. We used a bioinformatic approach to (1) test the hypothesis that loss of Pink1 in the PAG will influence the differential expression of genes that interact with Pink1, (2) highlight other key genes that relate to this type of Mendelian PD, and (3) catalog molecular targets that may be important for the production of rat vocalizations. Results Knockout of the Pink1 gene resulted in differentially expressed genes for both male and female rats that also mapped to human PD datasets. Pathway analysis highlighted several significant metabolic pathways. Weighted gene co-expression network analysis (WGCNA) was used to identify gene nodes and their interactions in (A) males, (B) females, and (C) combined-sexes datasets. For each analysis, within the module containing the Pink1 gene, Pink1 itself was the central node with the highest number of interactions with other genes including solute carriers, glutamate metabotropic receptors, and genes associated with protein localization. Strong connections between Pink1 and Krt2 and Hfe were found in both males and female datasets. In females a number of modules were significantly correlated with vocalization traits. Conclusions Overall, this work supports the premise that gene expression changes in the PAG may contribute to the vocal deficits observed in this PD rat model. Additionally, this dataset identifies genes that represent new therapeutic targets for PD voice disorders.

COMPARATIVE ICSH-ESTIMATIONS IN THE SERUM OF GONADECTOMIZED MALE AND FEMALE RATS WITH A TRANSPLANTED OVARY

1965 ◽  
Vol 49 (2) ◽  
pp. 239-247 ◽  
Author(s):  
T. Swelheim
Keyword(s):  
Female Rats ◽  
Ventral Prostate ◽  
High Dose ◽  
Corpora Lutea ◽  
Male And Female ◽  
Single High Dose ◽  
Base Level ◽  
Male And Female Rats ◽  
The Difference ◽  
The Right

ABSTRACT In adult female rats an ICSH-peak in the serum was found in the afternoon of pro-oestrus (preliminary experiments). ICSH was determined by the ventral prostate assay. Comparative ICSH-determinations were carried out in the serum of adult gonadectomized male and female rats with an ovarian transplant. Gonadectomy and transplantation of an ovary into the right hind-leg had been carried out two months previously. Irrespective as to whether there were corpora lutea in the transplants of castrated males, the ICSH-level in the serum of the males did not differ from the base level in the serum of the females. The ICSH-peak in the serum of the females (afternoon of pro-oestrus) exceeded this level. The relation between the ICSH-peak in the serum and ovulation was demonstrated by the fact that there was no ICSH-peak on the day of prooestrus in spayed females with an ovarian transplant, which in previous cycles had passed through a two days' oestrus. It is suggested that the difference in behaviour between ovarian transplants in spayed females and castrated males might be an expression of the same sex difference as that which appears in response to a single high dose of oestrogen.

Chronic alcohol feeding and its influence on c-Fos and heat shock protein-70 gene expression in different brain regions of male and female rats

Metabolism ◽  
2002 ◽  
Vol 51 (12) ◽  
pp. 1562-1568 ◽  
Author(s):  
Tatsuo Nakahara ◽  
Makoto Hirano ◽  
Hideyuki Uchimura ◽  
Sima Shirali ◽  
Colin R. Martin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Brain Regions ◽  
Female Rats ◽  
Chronic Alcohol ◽  
Male And Female ◽  
Male And Female Rats

Mammary gland morphology and gene expression signature of weanling male and female rats following exposure to exogenous estradiol

2013 ◽  
Vol 238 (9) ◽  
pp. 1033-1046 ◽  
Author(s):  
Isabelle R Miousse ◽  
Horacio Gomez-Acevedo ◽  
Neha Sharma ◽  
Jamie Vantrease ◽  
Leah Hennings ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Gene Expression Signature ◽  
Female Rats ◽  
Male And Female ◽  
Expression Signature ◽  
Male And Female Rats ◽  
Mammary Gland Morphology

scholarly journals Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?

2018 ◽  
Vol 5 (12) ◽  
pp. 2888-2897
Author(s):  
Samira Choopani ◽  
Sayyedehnikta Kasaei ◽  
Ardeshir Talebi ◽  
Mojgan Mortazavi ◽  
Yousef Gheisari ◽  
...  
Keyword(s):  
Kidney Tissue ◽  
Serum Levels ◽  
Female Rats ◽  
Histological Evaluation ◽  
High Dose ◽  
Kidney Transplant Patient ◽  
Male And Female ◽  
Male And Female Rats ◽  
Tissue Damages

Background: Cyclosporine (CYC) is an immunosuppressant drug used widely in kidney transplant patient. The major side effect of CYC is nephrotoxicity. In this study, three different doses of CYC alone or accompanied with zinc (Zn) supplement were administrated in male and female rats to determine the kidney tissue damages and functions. Methods: Male and female rats were treated with 10, 50 or 100 mg/kg/day of CYC alone or accompanied with 10 mg /kg/day of Zn sulfate for 10 days. The parameters related to renal function were determined and the kidney tissues were subjected to histological evaluation. Results: All male and female animals were treated with high dose CYC (100 mg/kg/day) alone or accompanied with Zn supplement during the experiment. The data obtained for the serum levels of creatinine (Cr) and blood urea nitrogen/Cr ratio, clearance of Cr, kidney weight (KW), sodium (Na) filtration rate, Na excretion rate and Na excretion fraction (%) in surviving animals suggest a role of gender in the variation of these factors. The kidney tissue damage score (KTDS) was increased as the dosage of CYC was elevated, and the Zn supplement attenuated the KTDS in animals treated with low dose CYC (10 mg/kg/day). Conclusion: The CYC-induced nephrotoxicity may be gender-related, and the 10 mg/kg dose of Zn sulphate as a supplement may possibly prevent the induced nephrotoxicity in males due to its antioxidant effects.  

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