scholarly journals The incentive amplifying effects of nicotine are reduced by selective and non-selective dopamine antagonists in rats

2014 ◽  
Vol 126 ◽  
pp. 50-62 ◽  
Author(s):  
Matthew I. Palmatier ◽  
Marissa R. Kellicut ◽  
A. Brianna Sheppard ◽  
Russell W. Brown ◽  
Donita L. Robinson
Keyword(s):  
Dopamine Antagonists ◽  
Selective Dopamine

scholarly journals Zebrafish Larvae's Response to Electricity is Mediated by Dopaminergic Agonists and Antagonists

2021 ◽  
Author(s):  
Arezoo Khalili ◽  
Ellen van Wijngaarden ◽  
Georg Zoidl ◽  
Pouya Rezai
Keyword(s):  
Dopamine Agonists ◽  
Molecular Mechanisms ◽  
Screening Method ◽  
Dopamine Antagonists ◽  
Electric Response ◽  
Dopaminergic Agonists ◽  
Chemical Screening ◽  
Zebrafish Larvae ◽  
Skf 81297 ◽  
Selective Dopamine

The signaling molecular mechanisms in zebrafish response to electricity are unknown, so here we asked if changes to dopaminergic signaling pathways can affect their electrically-evoked locomotion. To answer this question, the effects of multiple selective and non-selective dopamine compounds on the electric response of zebrafish larvae is investigated. A microfluidic device with enhanced control of experimentation with multiple larvae is used, which features a novel design to immobilize four zebrafish larvae in parallel and expose them to electric current that induces tail locomotion. In 6 days post-fertilization zebrafish larvae, the electric induced locomotor response is quantified in terms of the tail movement duration and beating frequency to discern the effect of non-lethal concentrations of dopaminergic agonists (apomorphine, SKF-81297, and quinpirole), and antagonists (butaclamol, SCH-23390, and haloperidol). All dopamine antagonists decrease locomotor activity, while dopamine agonists do not induce similar behaviours in larvae. The D2- like selective dopamine agonist quinpirole enhances movement. However, exposure to non-selective and D1-selective dopamine agonists apomorphine and SKF-81297 cause no significant change in the electric response. Exposing larvae that were pre-treated with butaclamol and haloperidol to apomorphine and quinpirole, respectively, restores electric locomotion. The results demonstrate a correlation between electric response and the dopamine signalling pathway. We propose that the electrofluidic assay has profound application potential as a chemical screening method when investigating biological pathways, behaviors, and brain disorders.

scholarly journals Repeated quinpirole treatment: Locomotor activity, dopamine synthesis, and effects of selective dopamine antagonists

Synapse ◽  
1995 ◽  
Vol 20 (3) ◽  
pp. 209-216 ◽  
Author(s):  
James K. Rowlett ◽  
Bruce A. Mattingly ◽  
Michael T. Bardo
Keyword(s):  
Locomotor Activity ◽  
Dopamine Antagonists ◽  
Dopamine Synthesis ◽  
Selective Dopamine

Selective dopamine antagonists reduce nicotine self-administration

1991 ◽  
Vol 104 (2) ◽  
pp. 171-176 ◽  
Author(s):  
William A. Corrigall ◽  
Kathleen M. Coen
Keyword(s):  
Dopamine Antagonists ◽  
Self Administration ◽  
Selective Dopamine
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