scholarly journals Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats

2012 ◽  
Vol 103 (2) ◽  
pp. 332-337 ◽  
Author(s):  
Christopher D. Schmoutz ◽  
Yanan Zhang ◽  
Scott P. Runyon ◽  
Nicholas E. Goeders
Keyword(s):  
Neuropeptide S ◽  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior

scholarly journals Maternal Diet Influences the Reinstatement of Cocaine-Seeking Behavior and the Expression of Melanocortin-4 Receptors in Female Offspring of Rats

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1462
Author(s):  
Dawid Gawliński ◽  
Kinga Gawlińska ◽  
Małgorzata Frankowska ◽  
Małgorzata Filip
Keyword(s):  
Maternal Diet ◽  
Dorsal Striatum ◽  
Brain Structures ◽  
Female Offspring ◽  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Pregnancy And Lactation ◽  
The Impact ◽  
Cocaine Reward

Recent studies have emphasized the role of the maternal diet in the development of mental disorders in offspring. Substance use disorder is a major global health and economic burden. Therefore, the search for predisposing factors for the development of this disease can contribute to reducing the health and social damage associated with addiction. In this study, we focused on the impact of the maternal diet on changes in melanocortin-4 (MC-4) receptors as well as on behavioral changes related to cocaine addiction. Rat dams consumed a high-fat diet (HFD), high-sugar diet (HSD, rich in sucrose), or mixed diet (MD) during pregnancy and lactation. Using an intravenous cocaine self-administration model, the susceptibility of female offspring to cocaine reward and cocaine-seeking propensities was evaluated. In addition, the level of MC-4 receptors in the rat brain structures related to cocaine reward and relapse was assessed. Modified maternal diets did not affect cocaine self-administration in offspring. However, the maternal HSD enhanced cocaine-seeking behavior in female offspring. In addition, we observed that the maternal HSD and MD led to increased expression of MC-4 receptors in the nucleus accumbens, while increased MC-4 receptor levels in the dorsal striatum were observed after exposure to the maternal HSD and HFD. Taken together, it can be concluded that a maternal HSD is an important factor that triggers cocaine-seeking behavior in female offspring and the expression of MC-4 receptors.

scholarly journals Fos Protein Expression and Cocaine-Seeking Behavior in Rats after Exposure to a Cocaine Self-Administration Environment

2000 ◽  
Vol 20 (2) ◽  
pp. 798-805 ◽  
Author(s):  
Janet L. Neisewander ◽  
David A. Baker ◽  
Rita A. Fuchs ◽  
Ly T. L. Tran-Nguyen ◽  
Art Palmer ◽  
...  
Keyword(s):  
Protein Expression ◽  
Self Administration ◽  
Fos Protein ◽  
Cocaine Seeking ◽  
Seeking Behavior

scholarly journals Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

2021 ◽  
Vol 12 ◽  
Author(s):  
Fushen Zhang ◽  
Shihao Huang ◽  
Haiyan Bu ◽  
Yu Zhou ◽  
Lixiang Chen ◽  
...  
Keyword(s):  
Spontaneous Recovery ◽  
Time Window ◽  
Mammalian Target Of Rapamycin ◽  
Self Administration ◽  
Mtor Inhibition ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Previously Treated ◽  
Cocaine Infusion ◽  
Paired Tone

Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsolidation of drug memories in conditioned place preference and alcohol self-administration (SA) paradigms. Here, we explored the effect of mTOR inhibition on reconsolidation of addiction memory using cocaine self-administration paradigm. Rats received intravenous cocaine self-administration training for 10 consecutive days, during which a light/tone conditioned stimulus was paired with each cocaine infusion. After acquisition of the stable cocaine self-administration behaviors, rats were subjected to nosepoke extinction (11 days) to extinguish their behaviors, and then received a 15 min retrieval trial with or without the cocaine-paired tone/light cue delivery or without. Immediately or 6 h after the retrieval trial, rapamycin (10 mg/kg) was administered intraperitoneally. Finally, cue-induced reinstatement, cocaine-priming-induced reinstatement and spontaneous recovery of cocaine-seeking behaviors were assessed in rapamycin previously treated animals, respectively. We found that rapamycin treatment immediately after a retrieval trial decreased subsequent reinstatement of cocaine seeking induced by cues or cocaine itself, and these effects lasted at least for 28 days. In contrast, delayed intraperitoneal injection of rapamycin 6 h after retrieval or rapamycin injection without retrieval had no effects on cocaine-seeking behaviors. These findings indicated that mTOR inhibition within the reconsolidation time-window impairs the reconsolidation of cocaine associated memory, reduces cocaine-seeking behavior and prevents relapse, and these effects are retrieval-dependent and temporal-specific.

scholarly journals DHEA, a Neurosteroid, Decreases Cocaine Self-Administration and Reinstatement of Cocaine-Seeking Behavior in Rats

2006 ◽  
Vol 31 (10) ◽  
pp. 2231-2236 ◽  
Author(s):  
Ravid Doron ◽  
Lilach Fridman ◽  
Iris Gispan-Herman ◽  
Rachel Maayan ◽  
Abraham Weizman ◽  
...  
Keyword(s):  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior

Effects of 7-OH-DPAT on cocaine-seeking behavior and on re-establishment of cocaine self-administration

2002 ◽  
Vol 72 (3) ◽  
pp. 623-632 ◽  
Author(s):  
Rita A Fuchs ◽  
Ly T.L Tran-Nguyen ◽  
Suzanne M Weber ◽  
Taline V Khroyan ◽  
Janet L Neisewander
Keyword(s):  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior

Cocaine-seeking Behavior and Fos Expression in the Amygdala Produced by Cocaine or a Cocaine Self-administration Environment

1999 ◽  
Vol 877 (1 ADVANCING FRO) ◽  
pp. 796-799 ◽  
Author(s):  
DAVID A. BAKER ◽  
RITA A. FUCHS ◽  
LY T.L. TRAN-NGUYEN ◽  
ART J. PALMER ◽  
JOHN F. MARSHALL ◽  
...  
Keyword(s):  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Fos Expression

Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake

2006 ◽  
Vol 186 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Jennifer L. Perry ◽  
Andrew D. Morgan ◽  
Justin J. Anker ◽  
Nancy K. Dess ◽  
Marilyn E. Carroll
Keyword(s):  
Self Administration ◽  
Saccharin Intake ◽  
Cocaine Seeking ◽  
Seeking Behavior

scholarly journals Dynamic CRMP2 regulation of CaV2.2 in the prefrontal cortex contributes to the reinstatement of cocaine seeking

2019 ◽  
Author(s):  
William C. Buchta ◽  
Aubin Moutal ◽  
Bethany Hines ◽  
Constanza Garcia-Keller ◽  
Alexander C.W. Smith ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Treatment Options ◽  
Health Concern ◽  
Self Administration ◽  
Drug Seeking ◽  
Binding Partner ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Medial Pfc

AbstractCocaine addiction is a major health concern with limited effective treatment options. A better understanding of mechanisms underlying relapse may help inform the development of new pharmacotherapies. Emerging evidence suggests that collapsin response mediator protein 2 (CRMP2) regulates presynaptic excitatory neurotransmission and contributes to pathological changes during diseases, such as neuropathic pain and substance use disorders. We examined the role of CRMP2 and its interactions with a known binding partner, CaV2.2, in cocaine-seeking behavior. We employed the rodent self-administration model of relapse to drug-seeking and focused on the prefrontal cortex (PFC) for its well-established role in reinstatement behaviors. Our results indicated that repeated cocaine self-administration resulted in a dynamic and persistent alteration in the PFC expression of CRMP2 and its binding partner, the CaV2.2 (N-type) voltage-gated calcium channel. Following cocaine self-administration and extinction training, the expression of both CRMP2 and CaV2.2 was reduced relative to Yoked saline controls. By contrast, cued-reinstatement potentiated CRMP2 expression and increased CaV2.2 expression above extinction levels. Lastly, we utilized the recently developed peptide myr-TAT-CBD3 to disrupt the interaction between CRMP2 and CaV2.2 in vivo. We assessed the reinstatement behavior after infusing this peptide directly into the medial PFC and found that it decreased cue-induced reinstatement of cocaine seeking. Taken together, these data suggest that neuroadaptations in the CRMP2/CaV2.2 signaling cascade in the PFC can facilitate drug seeking behavior. Targeting such interactions has implications for the treatment of cocaine relapse behavior.

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