scholarly journals Voluntary wheel running attenuates ethanol withdrawal-induced increases in seizure susceptibility in male and female rats

2012 ◽  
Vol 103 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Leslie L. Devaud ◽  
Shawn A. Walls ◽  
Walter D. McCulley ◽  
Alan M. Rosenwasser
Keyword(s):  
Wheel Running ◽  
Ethanol Withdrawal ◽  
Female Rats ◽  
Seizure Susceptibility ◽  
Voluntary Wheel Running ◽  
Male And Female ◽  
Male And Female Rats ◽  
Voluntary Wheel

Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats

2019 ◽  
Vol 155 ◽  
pp. 22-30
Author(s):  
Jenna R. Lee ◽  
Melissa A. Tapia ◽  
Valerie N. Weise ◽  
Emily L. Bathe ◽  
Victoria J. Vieira-Potter ◽  
...  
Keyword(s):  
Wheel Running ◽  
Female Rats ◽  
Voluntary Wheel Running ◽  
Male And Female ◽  
Male And Female Rats ◽  
Voluntary Wheel ◽  
Diet Preferences

scholarly journals Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats

2020 ◽  
Vol 377 ◽  
pp. 112235
Author(s):  
Dvijen C. Purohit ◽  
Atulya D. Mandyam ◽  
Michael J. Terranova ◽  
Chitra D. Mandyam
Keyword(s):  
Wheel Running ◽  
Female Rats ◽  
Voluntary Wheel Running ◽  
Male And Female ◽  
Male And Female Rats ◽  
Voluntary Wheel

scholarly journals Exploring sex differences in the prevention of ethanol drinking by naltrexone in dependent rats during abstinence

2018 ◽  
Author(s):  
A Matzeu ◽  
L Terenius ◽  
R Martin-Fardon
Keyword(s):  
Ethanol Withdrawal ◽  
Female Rats ◽  
Self Administration ◽  
Air Exposure ◽  
Male And Female ◽  
Motivational States ◽  
Male And Female Rats ◽  
The Central Nervous System ◽  
Males And Females ◽  
Time Of Intervention

AbstractBackgroundDespite considerable efforts, few drugs are available for the treatment of alcohol (ethanol [EtOH]) use disorders (AUDs). Ethanol directly or indirectly modulates several aspects of the central nervous system, including neurotransmitter/neuromodulator systems. Relapse vulnerability is a challenge for the treatment of EtOH addiction. Ethanol withdrawal symptoms create motivational states that lead to compulsive EtOH drinking and relapse even after long periods of abstinence. Among the therapeutics to treat AUDs, naltrexone (NTX) is a pharmacological treatment for relapse. The goal of the present study was to evaluate the effect of NTX on EtOH drinking in EtOH-dependent male and female rats during abstinence.MethodsWistar rats (males and females) were first trained to orally self-administer 10% EtOH. Half of them were then made dependent by chronic intermittent EtOH (CIE) vapor exposure, and the other half were exposed to air. Using this model, rats exhibit somatic and motivational signs of withdrawal. At the end of EtOH vapor (or air) exposure, the rats were tested for the effects of NTX (10 mg/kg, p.o.) on EtOH self-administration at three abstinence time points: acute abstinence (8 h, A-Abst), late abstinence (2 weeks, L-Abst), and protracted abstinence (6 weeks, P-Abst).ResultsNTX decreased EtOH intake in nondependent rats, regardless of sex and abstinence time point. In post-dependent rats, the effects of NTX improved with a longer abstinence time (i.e., L-Abst and P-Abst) in males, whereas it similarly reduced EtOH drinking in females at all abstinence points.ConclusionsThe data suggest that the therapeutic efficacy of NTX depends on the time of intervention during abstinence and sex. The data further suggest that EtOH dependence induces different neuroadaptations in male and female rats, reflected by differential effects of NTX. The results underscore the significance of considering the duration of EtOH abstinence and sex for the development of pharmacotherapeutic treatments for AUD.

Effects of wheel running on food intake and weight gain of male and female rats

1982 ◽  
Vol 28 (5) ◽  
pp. 899-903 ◽  
Author(s):  
Kumpei Tokuyama ◽  
Masayuki Saito ◽  
Hiromichi Okuda
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Wheel Running ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Comparison of changes in electrical activity, in isolated and in vivo hearts, induced by voluntary exercise in female rats

2020 ◽  
Author(s):  
Rachel Stones ◽  
Mark Drinkhill ◽  
Ed White
Keyword(s):  
Exercise Training ◽  
Electrical Activity ◽  
Wheel Running ◽  
Left Ventricular ◽  
Voluntary Exercise ◽  
Female Rats ◽  
Heart Weight ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

AbstractRegular mild exercise is recommended to the general population as beneficial to health. Regular exercise typically leads to structural and electrical remodelling of the heart but in human studies it is difficult to relate the extrinsic and intrinsic influences on intact hearts to changes seen at the single cell level. In this study we wished to test whether changes in electrical activity in intact hearts, in response to voluntary wheel running exercise training, were consistent with our previous observations in single cardiac myocytes and whether these changes resulted in altered susceptibility to arrhythmic stimuli.Female rats performed 5 weeks of voluntary wheel running. Implanted telemetry transmitters were used to measure electrocardiograms (ECGs) and determine heart rate variability (HRV) in conscious, unrestrained, trained (TRN) and sedentary (SED) animals. In isolated hearts, left ventricular epicardial monophasic action potentials (MAPs) were recorded and the responses to potentially arrhythmic interventions were assessed.Exercise training caused cardiac hypertrophy, as indexed by a significantly greater heart weight to body weight ratio. Consistent with previous measurements of action potential duration in single myocytes, MAPs were significantly longer at 50%, 75% and 90% repolarization. Arrhythmic susceptibility was not different between SED and TRN hearts. Trained animals displayed significantly altered HRV by week 5, in a manner consistent with reduced sympathetic tone, however resting ECG parameters, including those most associated with repolarisation duration, were unaltered. We conclude that intrinsic changes to cellular cardiac electrophysiology, induced by mild voluntary exercise, are not attenuated by the electronic loading that occurs in intact hearts. However, in vivo, extrinsic neuro-hormonal control of the heart may minimize the effects of intrinsic alterations in electrical activity.

Effects of Voluntary Wheel Running on Cardiac Function in Female Rats Receiving Chemical Ovariectomy

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S53
Author(s):  
David S. Hydock ◽  
Chia-Ying Lien ◽  
Carole M. Schneider ◽  
Reid Hayward
Keyword(s):  
Cardiac Function ◽  
Wheel Running ◽  
Female Rats ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel
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