Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice

2012 ◽  
Vol 103 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Berrak Yetimler ◽  
Gökhan Ulusoy ◽  
Turgay Çelik ◽  
Ewa Jakubowska-Doğru
Keyword(s):  
Fatty Acid ◽  
Differential Effect ◽  
Cognitive Status ◽  
The Brain ◽  
Effect Of Age

scholarly journals Differential effect of age on posterior and anterior hippocampal functional connectivity

NeuroImage ◽  
2016 ◽  
Vol 133 ◽  
pp. 468-476 ◽  
Author(s):  
Jessica S. Damoiseaux ◽  
Raymond P. Viviano ◽  
Peng Yuan ◽  
Naftali Raz
Keyword(s):  
Functional Connectivity ◽  
Differential Effect ◽  
Effect Of Age

scholarly journals Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 560
Author(s):  
An Cheng ◽  
Wenbin Jia ◽  
Ichiro Kawahata ◽  
Kohji Fukunaga
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Neuronal Loss ◽  
Krabbe Disease ◽  
Fatty Acid Binding Proteins ◽  
Mitochondrial Outer Membrane ◽  
Fatty Acid Binding ◽  
Mitochondrial Injury ◽  
Abnormal Accumulation ◽  
The Brain

Synucleinopathies are diverse diseases with motor and cognitive dysfunction due to progressive neuronal loss or demyelination, due to oligodendrocyte loss in the brain. While the etiology of neurodegenerative disorders (NDDs) is likely multifactorial, mitochondrial injury is one of the most vital factors in neuronal loss and oligodendrocyte dysfunction, especially in Parkinson’s disease, dementia with Lewy body, multiple system atrophy, and Krabbe disease. In recent years, the abnormal accumulation of highly neurotoxic α-synuclein in the mitochondrial membrane, which leads to mitochondrial dysfunction, was well studied. Furthermore, fatty acid-binding proteins (FABPs), which are members of a superfamily and are essential in fatty acid trafficking, were reported to trigger α-synuclein oligomerization in neurons and glial cells and to target the mitochondrial outer membrane, thereby causing mitochondrial loss. Here, we provide an updated overview of recent findings on FABP and α-synuclein interactions and mitochondrial injury in NDDs.

ChemInform Abstract: Role of Heart-Type Fatty Acid Binding Protein in the Brain Function

ChemInform ◽  
2009 ◽  
Vol 40 (26) ◽  
Author(s):  
Keiju Motohashi ◽  
Yui Yamamoto ◽  
Norifumi Shioda ◽  
Hisatake Kondo ◽  
Yuji Owada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Brain Function ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
The Brain

Effect of Age and Dietary Fat Level on Fatty Acid Oxidation in the Neonatal Pig

1978 ◽  
Vol 108 (10) ◽  
pp. 1621-1634 ◽  
Author(s):  
Ronald G. Wolfe ◽  
Charles V. Maxwell ◽  
Eldon C. Nelson
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Dietary Fat ◽  
Acid Oxidation ◽  
Fat Level ◽  
Neonatal Pig ◽  
Effect Of Age

scholarly journals Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. e1002266 ◽  
Author(s):  
Stuart G. Snowden ◽  
Amera A. Ebshiana ◽  
Abdul Hye ◽  
Yang An ◽  
Olga Pletnikova ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Alzheimer Disease ◽  
Cognitive Performance ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
The Brain ◽  
Metabolomic Study
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