Chronic inflammatory pain does not attenuate the development of tolerance to chronic morphine in adult male rats

2011 ◽  
Vol 98 (2) ◽  
pp. 325-330 ◽  
Author(s):  
Megan L. Uhelski ◽  
Jessica A. Boyette-Davis ◽  
Perry N. Fuchs
Keyword(s):  
Adult Male ◽  
Inflammatory Pain ◽  
Male Rats ◽  
Chronic Morphine ◽  
Chronic Inflammatory Pain ◽  
Development Of Tolerance

Chronic morphine reduces pain-related disability in a rodent model of chronic, inflammatory pain.

1999 ◽  
Vol 7 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Mark D. Lindner ◽  
Melissa A. Plone ◽  
Jonathan M. Francis ◽  
Chris K. Cain
Keyword(s):  
Inflammatory Pain ◽  
Rodent Model ◽  
Chronic Morphine ◽  
Chronic Inflammatory Pain

scholarly journals Chronic THC vapor rescues inflammation-related thermal hyperalgesia and causes cell type-specific modifications in vlPAG neurons

2021 ◽  
Author(s):  
Leslie K Kelley ◽  
Jason Middleton ◽  
Nicholas W. Gilpin ◽  
Savannah HM Lightfoot ◽  
Matthew N Hill
Keyword(s):  
Inflammatory Pain ◽  
Thermal Hyperalgesia ◽  
Suppressive Effect ◽  
Drug Dosage ◽  
Male Rats ◽  
Synaptic Inhibition ◽  
Duration Of Treatment ◽  
Action Potential Firing ◽  
Thermal Nociception ◽  
Chronic Inflammatory Pain

To reduce reliance on opioids for the treatment of pain in the clinic, ongoing work is testing the utility of cannabinoid drugs as a potential alternative for treatment of chronic pain and/or as a strategy for reducing opioid drug dosage and duration of treatment (i.e., so-called opioid-sparing effects). Previous preclinical work has shown robust anti-hyperalgesic effects of systemic THC and acute anti-hyperalgesic effects of vaporized THC. Here, we used a vapor inhalation model in rats to test chronic THC vapor inhalation effects on thermal nociception and mechanical sensitivity, as well as midbrain (i.e., periaqueductal gray [PAG]) neuronal function, in adult male rats with chronic inflammatory pain. We report that chronic THC vapor inhalation produces a robust anti-hyperalgesic effect in rats with chronic inflammatory pain, and that this effect persists 24 hours after cessation of THC exposure. We demonstrate that chronic THC vapor inhalation also modulates intrinsic and synaptic properties of ventrolateral PAG (vlPAG) neurons, including reductions in action potential firing rate and reductions in spontaneous inhibitory synaptic transmission, and that these effects occur specifically in neurons that respond to current input with a delayed firing phenotype. Finally, we show that the suppressive effect of the bath-applied mu-opioid receptor (MOR) agonist DAMGO on synaptic inhibition in the vlPAG is enhanced in slices taken from rats with a history of chronic THC vapor inhalation. Collectively, these data show that chronic THC vapor inhalation produces lasting attenuation of thermal hyperalgesia and reduces synaptic inhibition in the vlPAG of rats with chronic inflammatory pain.

Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

2014 ◽  
Author(s):  
Radoslav Omelka ◽  
Hana Chovancova ◽  
Ivana Bobonova ◽  
Grzegorz Formicki ◽  
Robert Toman ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats

Corticosteroid secretion after the soy extract application to orchidectomized adult male rats

2018 ◽  
Author(s):  
Vladimir Ajdzanovic ◽  
Dragana Miljic ◽  
Natasa Ristic ◽  
Lazo Pendovski ◽  
Florina Percinic-Popovska ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Corticosteroid Secretion
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