The effect of GABAA antagonist bicuculline on dorsal raphe nucleus and frontal cortex extracellular serotonin: A window on SWS and REM sleep modulation

2006 ◽  
Vol 83 (2) ◽  
pp. 314-321 ◽  
Author(s):  
Eldbjørg Fiske ◽  
Janne Grønli ◽  
Bjørn Bjorvatn ◽  
Reidun Ursin ◽  
Chiara Maria Portas
Keyword(s):  
Frontal Cortex ◽  
Rem Sleep ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Gabaa Antagonist ◽  
Dorsal Raphé ◽  
Sleep Modulation

Pre-frontal cortex, dorsal raphe nucleus, 5-HT1a, 5-HT1b receptors and escalated aggression in rodents

2010 ◽  
Author(s):  
Rosa Maria de Almeida ◽  
C. P. Veiga ◽  
L. Centenaro ◽  
K. Vieira ◽  
A. B. Lucion ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé

Pre-frontal cortex, dorsal raphe nucleus, 5-HT1a, 5-HT1b receptors and escalated aggression in rodents

2010 ◽  
Author(s):  
R. M. M. de Almeida ◽  
C. P. Veiga ◽  
L. Centenaro ◽  
K. Vieira ◽  
A. B. Lucion ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé

Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration

SLEEP ◽  
2021 ◽  
Author(s):  
Yun Lo ◽  
Pei-Lu Yi ◽  
Yi-Tse Hsiao ◽  
Fang-Chia Chang
Keyword(s):  
Locus Coeruleus ◽  
Rem Sleep ◽  
Energy Homeostasis ◽  
Dorsal Raphe Nucleus ◽  
Nrem Sleep ◽  
Dorsal Raphe ◽  
Wave Activity ◽  
Raphe Nucleus ◽  
Sleep Disruption ◽  
Dorsal Raphé

Abstract Hypocretin (hcrt) is a stress-reacting neuropeptide mediating arousal and energy homeostasis. An inescapable footshock stimulation (IFS) could initiate the hcrt release from the lateral hypothalamus (LHA) and suppresses rapid eye movement (REM) sleep in rodents. However, the effects of the IFS-induced hcrts on REM-off nuclei, the locus coeruleus (LC) and dorsal raphe nucleus (DRN), remained unclear. We hypothesized that the hcrt projections from the LHA to LC or DRN mediate IFS-induced sleep disruption. Our results demonstrated that the IFS increased hcrt expression and the neuronal activities in the LHA, hypothalamus, brainstem, thalamus, and amygdala. Suppressions of REM sleep and slow wave activity during non-REM (NREM) sleep caused by the high expression of hcrts were blocked when a non-specific and dual hcrt receptor antagonist was administered into the LC or DRN. Furthermore, the IFS also caused an elevated innate anxiety, but was limitedly influenced by the hcrt antagonist. This result suggests that the increased hcrt concentrations in the LC and DRN mediate stress-induced sleep disruptions and might partially involve IFS-induced anxiety.

Sign in / Sign up

Export Citation Format

Share Document