Hypoglycemic and antioxidant effect of Juniperus procera extract on rats with streptozotocin-induced diabetes

2019 ◽  
Vol 26 (3-4) ◽  
pp. 361-368
Author(s):  
Adel Alkhedaide ◽  
Mohamed Abdo Nassan ◽  
Tamer Ahmed Ismail ◽  
Mohamed Mohamed Soliman ◽  
Essam Hassan Mohamed ◽  
...  
Keyword(s):  
Antioxidant Effect ◽  
Streptozotocin Induced Diabetes ◽  
Juniperus Procera

scholarly journals Anti-diabetic and wound healing potential of Benincasa hispida in streptozotocin-induced diabetic rats

2021 ◽  
Vol 12 (2) ◽  
pp. 1539-1545
Author(s):  
Vemulapalli Ravi Kumar ◽  
Veerachamy Alagarsamy ◽  
Rakesh Kumar Jat
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Diabetic Rats ◽  
Antioxidant Effect ◽  
Antidiabetic Activity ◽  
Contraction Rate ◽  
Benincasa Hispida ◽  
Wide Range ◽  
Streptozotocin Induced Diabetes ◽  
Wound Healing Effect

Benincasa hispida (B.hispida) is a potential bioactive herb with a wide range of pharmacological actions.  Diabetes wound healing effect of effect of B.hispida is not clear. Hence the study was planned to investigate the antidiabetic and wound healing activities of methanolic and petroleum ether of B.hispida on streptozotocin-induced diabetes mellitus in Wistar rats. Diabetes was induced by a single intra peritoneal injection of Streptozocin (60mg/kg). The antidiabetic activity was studied at 50, 100 and 200 mg/kg body weight (BW) of plant extracts. In this study, STZ intoxicated rats displayed increased blood glucose level, lipid peroxidation and decreased level of antioxidants. Further, lipid profiles such as total cholesterol, triglycerides, LDL and VLDL were significantly increased and HDL was significantly decreased in STZ diabetic rats. Treatment with B.hispida methanolic and petroleum extracts at the dose of 100 and 200mg/kg showed significant antidiabetic activity. Further, in wounded rats, B.hispida significantly increased the wound contraction rate and shorten the period of epithelization. In conclusion, B.hispida showed a significant antidiabetic and wound activities mediated through its antioxidant effect.

scholarly journals The antioxidant effect of natural polyphenolic complexes of grape wine in the rat retina under streptozotocin-induced diabetes mellitus

2011 ◽  
Vol 5 (2) ◽  
pp. 61-72 ◽  
Author(s):  
A. R. Gnatush ◽  
◽  
V. R. Drel ◽  
A. Ya. Yalaneckyy ◽  
V. I. Mizin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Antioxidant Effect ◽  
Rat Retina ◽  
Streptozotocin Induced Diabetes ◽  
Grape Wine
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