Drospirenone-containing contraceptive exerts positive effects on cardiac uric acid and PAI-1 but not GSK-3: Improved safety profiles in contraception?

2019 ◽  
Vol 26 (3-4) ◽  
pp. 227-231
Author(s):  
Oluwaseun A. Adeyanju ◽  
Olaniyi A. Soetan ◽  
Lawrence A. Olatunji
Keyword(s):  
Uric Acid ◽  
Positive Effects ◽  
Pai 1

Hyperuricemia and Cardiovascular Disease

2019 ◽  
Vol 25 (6) ◽  
pp. 700-709 ◽  
Author(s):  
Shuangshuang Zhang ◽  
Yong Wang ◽  
Jinsong Cheng ◽  
Ning Huangfu ◽  
Ruochi Zhao ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Kidney Stones ◽  
Treatment Plan ◽  
Circulatory System ◽  
Special Focus ◽  
Positive Effects

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.

scholarly journals Perception and lived experience on health effects of natural hot spring water bath

2021 ◽  
Vol 9 (1) ◽  
pp. 39
Author(s):  
Sirjana Tiwari
Keyword(s):  
Uric Acid ◽  
Lived Experience ◽  
Hot Springs ◽  
Phenomenological Study ◽  
Skin Diseases ◽  
Hot Spring ◽  
Group Discussion ◽  
Spring Water ◽  
Water Bath ◽  
Positive Effects

Background: Natural hot spring bath has enormous health benefits. The water found in natural hot springs contains a variety of different minerals which shows positive benefits on rheumatism, skin diseases, gastritis, sinusitis, cardiac diseases, joint pain and many more. The healing effect is mostly from mineral composition.Methods: Phenomenological study was conducted on twenty-one participants who were taking natural hot spring water bath in Singha tatopani, Myagdi. Each participant was randomly selected. Eight In-depth interview and two focus group discussion were used for collecting information. People who have immediate bath experience were included in the study and those who were ill and not able to response the question due to illness were excluded from the study. Informed consent was taken from each participant before participation. Afterwards transcripts were transcribe and translated in English and analyzed using thematic analysis was done with the means of Ms. Excel.Results: Participants perceived natural hot spring water bath has positive effects on health and experience large sweating and excretion of urine while bathing. It helps to run their digestive system smoothly, improve blood circulation, and prevent skin problem, relief uric acid, sinusitis, pneumonia, tonsillitis, nose allergy, chest allergy, bronchitis and insomnia. Hot spring foment their pain organ and promote health of accidental victims, physically handicapped people, minimized uterine problem of women, eye itching and epiphora (watery eye).Conclusions: Common diseases Gastritis, rheumatism, skin disease, uric acid can be relieved by taking natural hot spring water bath as well as it help to promote and improve their health status. That’s why natural hot spring water bath can be a beneficial for improvement of public health.

scholarly journals Clinical Effects of Xanthine Oxidase Inhibitors in Hyperuricemic Patients

2020 ◽  
Author(s):  
Arrigo F.G. Cicero ◽  
Federica Fogacci ◽  
Raffaele Ivan Cincione ◽  
Giuliano Tocci ◽  
Claudio Borghi
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
English Language ◽  
Clinical Evidence ◽  
Oxidase Inhibitor ◽  
Clinical Effects ◽  
Xanthine Oxidase Inhibitor ◽  
Positive Effects ◽  
Xanthine Oxidase Inhibitors ◽  
First Choice

This review aim is to critically resume the available clinical evidence supporting the treatment of chronic hyperuricemia with xanthine-oxidase inhibitor activity. For this reason, all of the studies published in English language from 2000 to August 2019 on uric acid-lowering drugs have been carefully reviewed. The terms “serum uric acid”, “xanthine oxidase”, “allopurinol”, “febuxostat”, and “topiroxostat” have been incorporated into an electronic search strategy, alone and in combinations, in both MEDLINE (National Library of Medicine, Bethesda, MD) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). Even if new urate lowering drugs seem of particular efficacy for acute treatment of refractory hyperuricemia, their use is supported by relatively small clinical evidence: On the contrary, large long-term clinical trials have clearly demonstrated that xanthine oxidase inhibitors (namely, allopurinol and febuxostat) are effective, safe and relatively well-tolerated in the most part of patients. They have been largely tested in elderly, in patients affected by crhonic diseases such as heart failure and cancer, and in patients taking a large number of drugs, confirming their safety profile. Recent data also show that they could exert some positive effects on vascular health, renal function and glucose metabolism. Their cost is also low. In conclusion, xanthine oxidase inhibitors remain the first choice uric acid lowering drug for chronic treatment.

scholarly journals Role of Education of Diabetes to Controlling Plasma Glucose, Urea, Creatinine, Uric Acid in Central Hospital Nampula.

2018 ◽  
Vol 1 (09) ◽  
pp. 42-46
Author(s):  
Dr Madhumati Varma
Keyword(s):  
Uric Acid ◽  
Dietary Habits ◽  
Common Factor ◽  
Antiretroviral Drugs ◽  
Central Hospital ◽  
Positive Effects ◽  
Number Of Patients ◽  
Treatment Of Diabetes ◽  
The Impact

Modern approaches to diabetes primarily rely upon dietary and lifestyle management, often combined with regular ongoing blood glucose level monitoring. The diabetic education is a fundamental requirement of management of non-pharmacological treatment of diabetes. Medication alone not able to control diabetes. There should be patient behavior changed from continuing learning about diet, physiology, continues learning, preventive management of complication of diabetes, knowledge of diseases, self-managing small problem and inform to medical staff, use information technology .    There is fast and gradually increasing number of patients with diabetes in Mozambique due to a pattern of poor dietary habits, sedentary lifestyle, urbanization, obesity, and the use of traditional healers for the treatment of diabetes, which leads to complications such as diabetic foot and the amputation of feet. Another common factor to complication diabetes is the impact of the antiretroviral drugs used to treat HIV on diabetes. Diabetes education was performed with general and specific groups of patients according to the needs of the patients, the complications of the diabetes mellitus and other diseases associated with them. Three education sessions were organized at central hospital Nampula at an interval of one month (baseline, first follow up and second follow up). Each participant was evaluated in each session regarding their plasm glucose, uric acid, and creatinine and urea concentrations. The statistical analysis showed strong significantly correlation positive effects on controlling each of these parameter.

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

2020 ◽  
Vol 63 (4) ◽  
pp. 1018-1032
Author(s):  
Chia-Hsin Wu ◽  
Roger W. Chan
Keyword(s):  
Acoustic Analysis ◽  
Vocal Tract ◽  
Exercise Program ◽  
Analysis Of Covariance ◽  
Elderly Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Positive Effects ◽  
Aging Voice ◽  
Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

Clinical Success Using the Audio-Visual Feedback Training for Cluttering

2019 ◽  
Vol 4 (6) ◽  
pp. 1589-1594
Author(s):  
Yvonne van Zaalen ◽  
Isabella Reichel
Keyword(s):  
Visual Feedback ◽  
Clinical Success ◽  
Pause Duration ◽  
Digital Audio ◽  
Male Adolescents ◽  
Feedback Training ◽  
Positive Effects ◽  
Speech Monitoring ◽  
Adolescents And Adults

Purpose Among the best strategies to address inadequate speech monitoring skills and other parameters of communication in people with cluttering (PWC) is the relatively new but very promising auditory–visual feedback (AVF) training ( van Zaalen & Reichel, 2015 ). This study examines the effects of AVF training on articulatory accuracy, pause duration, frequency, and type of disfluencies of PWC, as well as on the emotional and cognitive aspects that may be present in clients with this communication disorder ( Reichel, 2010 ; van Zaalen & Reichel, 2015 ). Methods In this study, 12 male adolescents and adults—6 with phonological and 6 with syntactic cluttering—were provided with weekly AVF training for 12 weeks, with a 3-month follow-up. Data was gathered on baseline (T0), Week 6 (T1), Week 12 (T2), and after follow-up (T3). Spontaneous speech was recorded and analyzed by using digital audio-recording and speech analysis software known as Praat ( Boersma & Weenink, 2017 ). Results The results of this study indicated that PWC demonstrated significant improvements in articulatory rate measurements and in pause duration following the AVF training. In addition, the PWC in the study reported positive effects on their ability to retell a story and to speak in more complete sentences. PWC felt better about formulating their ideas and were more satisfied with their interactions with people around them. Conclusions The AVF training was found to be an effective approach for improving monitoring skills of PWC with both quantitative and qualitative benefits in the behavioral, cognitive, emotional, and social domains of communication.

Positive effects of glucocorticoids on T cell function and development by upregulation of interleukin-7 receptor α

2001 ◽  
Vol 120 (5) ◽  
pp. A314-A315
Author(s):  
D FRANCHIMONT ◽  
J GALON ◽  
M VACCHIO ◽  
R VISCONTI ◽  
G CHROUSOS ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Positive Effects ◽  
Interleukin 7 ◽  
T Cell Function

943: Plasminogen Activator Inhibitor 1 (PAI-1) is Increased in Human Peyronie's Disease

2005 ◽  
Vol 173 (4S) ◽  
pp. 255-255 ◽  
Author(s):  
Hugo H. Davila ◽  
Thomas R. Magee ◽  
Freddy Zuniga ◽  
Jacob Rajfer ◽  
Nestor F. GonzalezCadavid
Keyword(s):  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Peyronie’S Disease ◽  
Plasminogen Activator Inhibitor 1 ◽  
Peyronie's Disease ◽  
Activator Inhibitor ◽  
Pai 1
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