WITHDRAWN: Histological difference of Soleus Muscle fibers due to Sciatic Nerve Transection in Rats

2018 ◽  
Author(s):  
Obidallah Aljaghthmi ◽  
Isam Abu Zeid ◽  
Hassan Heba ◽  
Sherif Hassan
Keyword(s):  
Sciatic Nerve ◽  
Soleus Muscle ◽  
Muscle Fibers ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Histological Difference

scholarly journals Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shih-Tien Hsu ◽  
Chun-Hsu Yao ◽  
Yuan-Man Hsu ◽  
Jia-Horng Lin ◽  
Yung-Hsiang Chen ◽  
...  
Keyword(s):  
Growth Factors ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Transection ◽  
Cremophor El ◽  
Neuronal Connectivity ◽  
Sciatic Nerve Transection ◽  
Expression Levels ◽  
Nerve Growth Factors

Abstract Recent studies describe taxol as a candidate treatment for promoting central nerve regeneration. However, taxol has serious side effects including peripheral neurotoxicity, and little information is known about the effect of taxol on peripheral nerve regeneration. We investigated the effects of taxol on regeneration in a rat sciatic nerve transection model. Rats were divided into four groups (n = 10): normal saline (i.p.) as the control, Cremophor EL vehicle, and 2 or 6 mg/kg of taxol in the Cremophor EL solution (four times in day-2, 4, 6, and 8), respectively. We evaluated neuronal electrophysiology, animal behaviour, neuronal connectivity, macrophage infiltration, location and expression levels of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors and immunoregulatory factors. In the high-dose taxol group (6 mg/kg), neuronal electrophysiological function was significantly impaired. Licking latencies were significantly changed while motor coordination was unaffected. Neuronal connectivity, macrophage density, and expression levels of CGRP was dramatically reduced. Expression levels of nerve growth factors and immunoregulatory factors was also reduced, while it was increased in the low-dose taxol group (2 mg/kg). These results indicate that taxol can modulate local inflammatory conditions, impair nerve regeneration, and impede recovery of a severe peripheral nerve injury.

Functional Effects of Local Administration of Thyroid Hormone Combined With Chitosan Conduit After Sciatic Nerve Transection in Rats

2013 ◽  
Vol 71 (10) ◽  
pp. 1763-1776 ◽  
Author(s):  
Rahim Mohammadi ◽  
Keyvan Amini ◽  
Alireza Yousefi ◽  
Mehdi Abdollahi-Pirbazari ◽  
Abolfazl Belbasi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Sciatic Nerve ◽  
Local Administration ◽  
Nerve Transection ◽  
Sciatic Nerve Transection

scholarly journals Neuroprotective effect of ischemic postconditioning on sciatic nerve transection

2018 ◽  
Vol 13 (3) ◽  
pp. 492 ◽  
Author(s):  
Jun-lin Zhou ◽  
Xiao-bin Zhou ◽  
Na Liu ◽  
Dong Wang ◽  
De-xin Zou ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Neuroprotective Effect ◽  
Ischemic Postconditioning ◽  
Nerve Transection ◽  
Sciatic Nerve Transection
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