Pronociceptive changes in response properties of caudal medullary neurons in colitis

Olga Lyubashina; Ivan Sivachenko; Irina Busygina; Sergey Panteleev

doi:10.1016/j.pathophys.2018.07.193

Pronociceptive changes in response properties of caudal medullary neurons in colitis

Pathophysiology ◽

10.1016/j.pathophys.2018.07.193 ◽

2018 ◽

Vol 25 (3) ◽

pp. 208

Author(s):

Olga Lyubashina ◽

Ivan Sivachenko ◽

Irina Busygina ◽

Sergey Panteleev

Keyword(s):

Response Properties ◽

Medullary Neurons

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Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine

Journal of Neurophysiology ◽

10.1152/jn.00343.2020 ◽

2020 ◽

Vol 124 (3) ◽

pp. 790-801

Author(s):

Hanna Viisanen ◽

Tuomas O. Lilius ◽

Boriss Sagalajev ◽

Pekka Rauhala ◽

Eija Kalso ◽

...

Keyword(s):

Pain Control ◽

Chronic Treatment ◽

Analgesic Tolerance ◽

Response Properties ◽

Aspartate Receptor ◽

Antinociceptive Tolerance ◽

Strong Opioids ◽

Medullary Neurons

Morphine and oxycodone are two clinically used strong opioids. Chronic treatment with oxycodone as well as morphine can lead to analgesic tolerance and paradoxical hyperalgesia. Here we show that an N-methyl-d-aspartate receptor-dependent pronociceptive change in discharge properties of rostroventromedial medullary neurons controlling spinal nociception has an important role in antinociceptive tolerance to morphine but not oxycodone. Interestingly, chronic oxycodone did not induce pronociceptive changes in the rostroventromedial medulla.

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Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy

European Journal of Neuroscience ◽

10.1111/j.1460-9568.2007.05832.x ◽

2007 ◽

Vol 26 (8) ◽

pp. 2188-2195 ◽

Cited By ~ 38

Author(s):

Leonor Gonçalves ◽

Armando Almeida ◽

Antti Pertovaara

Keyword(s):

Peripheral Neuropathy ◽

Rat Model ◽

Response Properties ◽

Medullary Neurons

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206 NEUROPLASTICITY IN RESPONSE PROPERTIES OF ROSTROVENTROMEDIAL MEDULLARY NEURONS IN ANIMALS WITH A SPARED NERVE INJURY MODEL OF NEUROPATHY

European Journal of Pain ◽

10.1016/s1090-3801(06)60209-7 ◽

2006 ◽

Vol 10 (S1) ◽

pp. S56b-S57

Author(s):

L. Gonçalves ◽

A. Almeida ◽

A. Pertovaara

Keyword(s):

Nerve Injury ◽

Spared Nerve Injury ◽

Response Properties ◽

Injury Model ◽

Medullary Neurons

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A First Principles Approach for Partitioning Linear Response Properties into Additive and Cooperative Contributions

10.26434/chemrxiv.5773968.v1 ◽

2018 ◽

Cited By ~ 1

Author(s):

Daniel Lambrecht ◽

Eric Berquist

Keyword(s):

First Principles ◽

Linear Response ◽

Building Blocks ◽

Field Method ◽

Response Property ◽

Response Properties ◽

Consistent Field ◽

Molecular Building Blocks ◽

Self Consistent ◽

Self Consistent Field

We present a first principles approach for decomposing molecular linear response properties into orthogonal (additive) plus non-orthogonal/cooperative contributions. This approach enables one to 1) identify the contributions of molecular building blocks like functional groups or monomer units to a given response property and 2) quantify cooperativity between these contributions. In analogy to the self consistent field method for molecular interactions, SCF(MI), we term our approach LR(MI). The theory, implementation and pilot data are described in detail in the manuscript and supporting information.

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