MORE EFFICIENT SUPPRESSION OF ENDOTHELIAL CELL METABOLISM WITH SIMULTANEOUS INHIBITION OF GLYCOLYSIS AND TYROSINE KINASE RECEPTOR ACTIVITY

2018 ◽  
Vol 25 (3) ◽  
pp. 171
Author(s):  
Jana Horváthová ◽  
Roman Moravčík ◽  
Andrej Boháč ◽  
Michal Zeman
Keyword(s):  
Endothelial Cell ◽  
Tyrosine Kinase ◽  
Cell Metabolism ◽  
Receptor Activity ◽  
Tyrosine Kinase Receptor ◽  
Efficient Suppression ◽  
Inhibition Of Glycolysis ◽  
Simultaneous Inhibition ◽  
Endothelial Cell Metabolism

scholarly journals Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3

2015 ◽  
Vol 35 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Anuradha Doddaballapur ◽  
Katharina M. Michalik ◽  
Yosif Manavski ◽  
Tina Lucas ◽  
Riekelt H. Houtkooper ◽  
...  
Keyword(s):  
Shear Stress ◽  
Endothelial Cell ◽  
Cell Metabolism ◽  
Laminar Shear Stress ◽  
Laminar Shear ◽  
Endothelial Cell Metabolism

ENMET: Endothelial Cell Metabolism Mathematical Model

2009 ◽  
Author(s):  
Gianni Orsi ◽  
Carmelo De Maria ◽  
Federico Vozzi ◽  
Mariangela Guzzardi ◽  
Arti Ahluwalia ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Endothelial Cell ◽  
Cell Metabolism ◽  
Endothelial Cell Metabolism

scholarly journals The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis

2020 ◽  
Vol 21 (10) ◽  
pp. 3633 ◽  
Author(s):  
Khalia R. Primer ◽  
Peter J. Psaltis ◽  
Joanne T.M. Tan ◽  
Christina A. Bursill
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
High Density ◽  
Metabolic Reprogramming ◽  
High Density Lipoproteins ◽  
Impaired Wound Healing ◽  
Endothelial Cell Function ◽  
Positive Effects ◽  
Impaired Angiogenesis ◽  
Endothelial Cell Metabolism

Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing evidence that high-density lipoproteins (HDL) can rescue diabetes-impaired angiogenesis through a number of mechanisms, including the modulation of endothelial cell metabolic reprogramming. Endothelial cell metabolic reprogramming in response to tissue ischaemia is a driver of angiogenesis and is dysregulated by diabetes. Specifically, diabetes impairs pathways that allow endothelial cells to upregulate glycolysis in response to hypoxia adequately and impairs suppression of mitochondrial respiration. HDL rescues the impairment of the central hypoxia signalling pathway, which regulates these metabolic changes, and this may underpin several of its known pro-angiogenic effects. This review discusses the current understanding of endothelial cell metabolism and how diabetes leads to its dysregulation whilst examining the various positive effects of HDL on endothelial cell function.

scholarly journals Evaluation of first trimester serum soluble endothelial cell-specific tyrosine kinase receptor in normal and affected pregnancies

2014 ◽  
Vol 28 (15) ◽  
pp. 1815-1821
Author(s):  
Francisco J Schneuer ◽  
Natasha Nassar ◽  
Cyrille Guilbert ◽  
Vitomir Tasevski ◽  
Anthony W Ashton ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tyrosine Kinase ◽  
First Trimester ◽  
Tyrosine Kinase Receptor

Influence of nutrients and cytokines on endothelial cell metabolism.

1994 ◽  
Vol 13 (3) ◽  
pp. 224-231 ◽  
Author(s):  
B Hennig ◽  
J N Diana ◽  
M Toborek ◽  
C J McClain
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
Endothelial Cell Metabolism

Nutrition, endothelial cell metabolism, and atherosclerosis

1994 ◽  
Vol 34 (3) ◽  
pp. 253-282 ◽  
Author(s):  
Bernhard Hennig ◽  
Michal Toborek ◽  
Angelina Alvarado Cader ◽  
Eric A. Decker ◽  
Mary A. Stuart
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
Endothelial Cell Metabolism

scholarly journals Endothelial cell metabolism

2017 ◽  
Vol 24 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Laure-Anne Teuwen ◽  
Nihed Draoui ◽  
Charlotte Dubois ◽  
Peter Carmeliet
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
Endothelial Cell Metabolism
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