Antioxidant and antiapoptotic effects of green tea polyphenols against azathioprine-induced liver injury in rats

2011 ◽  
Vol 18 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Hesham A. El-Beshbishy ◽  
Ola M. Tork ◽  
Mohamed F. El-Bab ◽  
Mohamed A. Autifi
Keyword(s):  
Liver Injury ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

scholarly journals Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Le Lv ◽  
Chenshu Xu ◽  
Xiaoye Mo ◽  
Hai-Yan Sun ◽  
Huichang Bi
Keyword(s):  
Survival Rate ◽  
Liver Injury ◽  
Protein Expression ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Apap Overdose ◽  
Different Doses

Green tea polyphenols (GTPs) have been shown to exhibit diverse beneficial effects against a variety of diseases. Acetaminophen (APAP) overdose is one of the most frequent causes of drug-induced liver injury. In the current study, we aimed to investigate the protective effect of GTP on APAP-induced liver injury in mice and the underlying mechanisms involved. Male C57BL/6J mice were treated orally with different doses of GTP (37.5, 75, or 150 mg/kg) 4 h after APAP overdose (400 mg/kg) and continuously given every 8 h until sacrificed at 4, 12, 20, and 48 h after the first treatment of GTP. Survival rate and histological and biochemical assessments were performed to evaluate the APAP-induced liver injury. Protein expression of multiple drug metabolizing enzymes and transporters was measured to demonstrate the possible mechanisms involved. Our results revealed that administration of different doses of GTP significantly alleviated APAP-induced liver injury by improving the survival rate, hepatocellular necrosis, and ALT/AST/GSH levels after APAP overdose (400 mg/kg). The protein expression of APAP-induced drug transporters and metabolizing enzymes was mostly induced by GTP treatment, which was followed by reduction in drug transporters at the later time points. The current study collectively demonstrated that GTP protects against APAP-induced liver injury, possibly through regulating drug metabolizing enzymes and transporters after APAP overdose.

Topical Green Tea Polyphenols and Caffeine as a Treatment for Acne Vulgaris

2017 ◽  
Vol 1 ◽  
pp. s55
Author(s):  
Sarah Y Siu ◽  
Georgina M Ferzli ◽  
Neil Brody
Keyword(s):  
Green Tea ◽  
Acne Vulgaris ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Abstract Not Available

Antimutagenic activity of green tea polyphenols

1989 ◽  
Vol 223 (3) ◽  
pp. 273-285 ◽  
Author(s):  
Zhi Y. Wang ◽  
Shu J. Cheng ◽  
Zong C. Zhou ◽  
Mohammad Athar ◽  
Wasiuddin A. Khan ◽  
...  
Keyword(s):  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Antimutagenic Activity

Supplementation with Green Tea Polyphenols Improves Bone Microstructure and Quality in Aged, Orchidectomized Rats

2011 ◽  
Vol 88 (6) ◽  
pp. 455-463 ◽  
Author(s):  
Chwan-Li Shen ◽  
Jay J. Cao ◽  
Raul Y. Dagda ◽  
Thomas E. Tenner ◽  
Ming-Chien Chyu ◽  
...  
Keyword(s):  
Green Tea ◽  
Bone Microstructure ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Complexation/encapsulation of green tea polyphenols in mixed calcium carbonate and phosphate micro-particles

2010 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Amal Elabbadi ◽  
Nicolas Jeckelmann ◽  
Olivier P. Haefliger ◽  
Lahoussine Ouali
Keyword(s):  
Calcium Carbonate ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Micro Particles
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