Influence of maternal nicotine exposure during gestation and lactation on lactate dehydrogenase isoenzyme profile and transcript levels in developing neonatal rat lung

2008 ◽  
Vol 15 (1) ◽  
pp. 1-8 ◽  
Author(s):  
K. Gamieldien ◽  
G.S. Maritz
Keyword(s):  
Lactate Dehydrogenase ◽  
Neonatal Rat ◽  
Nicotine Exposure ◽  
Rat Lung ◽  
Transcript Levels ◽  
Dehydrogenase Isoenzyme

Biomedical response of neonatal rat lung to maternal nicotine exposure

1995 ◽  
Vol 2 (1) ◽  
pp. 47-54 ◽  
Author(s):  
G.S. Maritz ◽  
K. Najaar
Keyword(s):  
Neonatal Rat ◽  
Nicotine Exposure ◽  
Rat Lung

Maternal copper supplementation protects the neonatal rat lung against the adverse effects of maternal nicotine exposure

2000 ◽  
Vol 12 (2) ◽  
pp. 97 ◽  
Author(s):  
G. S. Maritz ◽  
H. L. Matthews ◽  
J. Aalbers
Keyword(s):  
Adverse Effects ◽  
Lung Development ◽  
Lysyl Oxidase ◽  
Neonatal Rat ◽  
Control Group ◽  
Nicotine Exposure ◽  
Rat Lung ◽  
Alveolar Volume ◽  
Copper Supplementation ◽  
Neonatal Lung

Maternal nicotine exposure interferes with the extracellular formation of the connective tissue frame-work of the neonatal lung, a process that is dependent on copper-dependent lysyl oxidase. It has been shown that, during the phase of lung development associated with alveolarization, maternal nicotine exposure resulted in a reduction in the copper content and thus conceivably in the activity of lysyl oxidase of the neonatal lung. Therefore the aims of this study were (a) to determine the effects of maternal nicotine exposure during gestation and lactation on neonatal lung development, and (b) to establish whether maternal copper supplementation during gestation and lactation prevented the effect of maternal nicotine exposure on neonatal lung development. Pregnant rats were randomly divided into four groups: the control group received saline; the second group received 1 mg nicotine (kg bodyweight)–1 day–1 subcutaneously; the third group received 1 mg copper (kg bodyweight)–1 day–1; and the fourth group received both nicotine and copper in the same quantities as the previous two groups. Lung tissue of 14- and 42-day-old rat pups were processed for light microscopy. Maternal nicotine exposure during gestation and lactation resulted in (a) decreased alveolar number, (b) reduced internal surface area and (c) increased alveolar volume. Copper supplementation during gestation and lactation prevented the adverse effects of maternal nicotine exposure during gestation and lactation on the development of the alveolar region of the rat lung.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme
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