“Thermoregulation-dependent component” in pathophysiology of motor disorders in Parkinson's disease?

2005 ◽  
Vol 11 (4) ◽  
pp. 187-196 ◽  
Author(s):  
Alexander Meigal ◽  
Yurij Lupandin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Disorders ◽  
Dependent Component

scholarly journals Technologies for Assessment of Motor Disorders in Parkinson’s Disease: A Review

Sensors ◽  
2015 ◽  
Vol 15 (9) ◽  
pp. 21710-21745 ◽  
Author(s):  
Qi Oung ◽  
Hariharan Muthusamy ◽  
Hoi Lee ◽  
Shafriza Basah ◽  
Sazali Yaacob ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Disorders

scholarly journals Nitric Oxide Modulation of the Basal Ganglia Circuitry: Therapeutic Implication for Parkinson's Disease and Other Motor Disorders

2011 ◽  
Vol 10 (7) ◽  
pp. 777-791 ◽  
Author(s):  
Massimo Pierucci ◽  
Salvatore Galati ◽  
Mario Valentino ◽  
Vincenzo Di Matteo ◽  
Arcangelo Benigno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Therapeutic Implication ◽  
Motor Disorders

Weak detrusor contractility correlates with motor disorders in Parkinson's disease

2012 ◽  
Vol 27 (14) ◽  
pp. 1775-1780 ◽  
Author(s):  
Keiichiro Terayama ◽  
Ryuji Sakakibara ◽  
Akihiro Ogawa ◽  
Hiroyuki Haruta ◽  
Takashi Akiba ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Disorders ◽  
Detrusor Contractility

Motor Disorders and Impaired Electrical Power of Pallidal EEG Improved by Gallic Acid in Animal Model of Parkinson’s Disease

2011 ◽  
Vol 14 (24) ◽  
pp. 1109-1116 ◽  
Author(s):  
Maryam Jafar Sameri ◽  
Alireza Sarkaki ◽  
Yaghoub Farbood ◽  
Seyed Mohammad Taghi Mansouri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Gallic Acid ◽  
Electrical Power ◽  
Motor Disorders

scholarly journals The dynamic of basal ganglia activity with a multiple covariance method: influences of Parkinson’s disease

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Clara Rodriguez-Sabate ◽  
Ingrid Morales ◽  
Ricardo Puertas-Avendaño ◽  
Manuel Rodriguez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Closed Loop ◽  
Clinical Manifestations ◽  
Motor Disorders ◽  
Loop Model ◽  
Functional Profile ◽  
Motor Circuit ◽  
Profile Method

Abstract The closed-loop cortico-subcortical pathways of basal ganglia have been extensively used to describe the physiology of these centres and to justify the functional disorders of basal ganglia diseases. This approach justifies some experimental and clinical data but not others, and furthermore, it does not include a number of subcortical circuits that may produce a more complex basal ganglia dynamic than that expected for closed-loop linear networks. This work studied the functional connectivity of the main regions of the basal ganglia motor circuit with magnetic resonance imaging and a new method (functional profile method), which can analyse the multiple covariant activity of human basal ganglia. The functional profile method identified the most frequent covariant functional status (profiles) of the basal ganglia motor circuit, ordering them according to their relative frequency and identifying the most frequent successions between profiles (profile transitions). The functional profile method classified profiles as input profiles that accept the information coming from other networks, output profiles involved in the output of processed information to other networks and highly interconnected internal profiles that accept transitions from input profiles and send transitions to output profiles. Profile transitions showed a previously unobserved functional dynamic of human basal ganglia, suggesting that the basal ganglia motor circuit may work as a dynamic multiple covariance network. The number of internal profiles and internal transitions showed a striking decrease in patients with Parkinson’s disease, a fact not observed for input and output profiles. This suggests that basal ganglia of patients with Parkinson’s disease respond to requirements coming from other neuronal networks, but because the internal processing of information is drastically weakened, its response will be insufficient and perhaps also self-defeating. These marked effects were found in patients with few motor disorders, suggesting that the functional profile method may be an early procedure to detect the first stages of the Parkinson’s disease when the motor disorders are not very evident. The multiple covariance activity found presents a complementary point of view to the cortico-subcortical closed-loop model of basal ganglia. The functional profile method may be easily applied to other brain networks, and it may provide additional explanations for the clinical manifestations of other basal ganglia disorders.

scholarly journals EVALUATION OF THE INFLUENCE OF MOTOR DISORDERS ON THE QUALITY OF LIFE OF PATIENTS WITH COMOBIDITY OF PARKINSON'S DISEASE AND FRAILTY AND THE EFFICIENCY OF THEIR CORRECTION BY PHYSICAL THERAPY

2021 ◽  
Vol 1 (15) ◽  
pp. 22-30
Author(s):  
I.V. Didoha
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Therapy ◽  
Elderly Patients ◽  
Point Of View ◽  
Motor Disorders ◽  
Functional Training ◽  
Patient Centric

Summary. Purpose of the study: to assess the effect of motor disorders on the quality of life of elderly patients with comobility of Parkinson's disease and frailty and to evaluate the effectiveness of their correction by means of physical therapy. Material and methods. 57 elderly people with diagnosed Parkinson's disease in combination with frailty were examined. They were divided into two groups: 1 (practiced according to the principles of polyclinic rehabilitation) and 2 (practiced according to a developed program of physical therapy, which was created from the point of view of a patient-centric model of rehabilitation, taking into account the specifics of each polymorbid state with the use of functional training, massage, ergotherapy, correction food). In the course of physical therapy, we consistently achieved individual short- and long-term goals of rehabilitation in the SMART format. The effectiveness of the program was assessed by the dynamics of the MDS Unified Parkinson's Disease Rating Scale, Schwab-England, PDQ-39.  Results. The examined persons were found to have significant motor disorders, deterioration in the activity of everyday life and everyday activity and, as a consequence, a decrease in the quality of life. The developed program of physical therapy, created from the point of view of a patient-centric model of rehabilitation with the use of functional training, therapeutic exercises, massage, ergotherapy, nutrition correction, revealed a statistically significant better effect on the indicators of motor functions, the state of daily and household activity and the quality of life in comparison with the general polyclinic program. for all studied indicators (p <0.05). Findings. Elderly patients with comorbidity of Parkinson's disease and senile asthenia require the development of individual programs of physical therapy, taking into account and correcting the specificity of each disease, which increases the overall effectiveness of rehabilitation.

Neuro-psychological features of non-motor disorders in Parkinson's disease // Journal of Medical and Pharmaceutical Research No.1(5), 2019/ Chief Editor Thomas Fisher /OEAPS Inc.(Open European Academy of Public Sciences). Basel, Switzerland. 24.03.2019: OEAPS Inc., 2018. - PP.24-28.

2019 ◽  
Author(s):  
Solomiia Bandrivska
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pharmaceutical Research ◽  
Clinical Manifestations ◽  
Chief Editor ◽  
Motor Disorders ◽  
European Academy ◽  
Wide Range ◽  
The Central Nervous System ◽  
Psychological Features

Parkinson's disease (PD) - is a chronic progressive degenerative disease of the central nervous system, the main clinical manifestations of which are hypokinesia, rigidity, resting tremor, postural disorders, which as the disease progresses grow and eventually lead to immobility of patients [Stok V. N., Fedorova N.V., 1997, Jahno N.N., 1995]. Modern anti parkinson therapy is mainly symptomatic and, apparently, does not affect the current degeneration process. Therefore, even with the optimal treatment today, disability of the patient is inevitable in the future. In addition to classical motor disorders, the cause of disability can be a wide range of non-motor disorders (mental , vegetative , sensory).

scholarly journals Chicoric acid prevents neurodegeneration via microbiota-gut-brain axis in a mouse Parkinson's disease model

2021 ◽  
Author(s):  
He Qian ◽  
Ning Wang ◽  
Xinyue Pan ◽  
Yahui Guo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
16S Rrna ◽  
Microbial Diversity ◽  
Dopaminergic Neurons ◽  
Disease Model ◽  
Signaling Cascade ◽  
Motor Disorders ◽  
Chicoric Acid ◽  
Microbial Dysbiosis

It is determined that microbiota-gut-brain axis is involved in the pathogenesis of Parkinson's Disease (PD) and may be the potential target for developing the therapeutic treatments for PD. Chicoric acid (CA) is a kind of natural polyphenolic acid compounds which are recognized as promising agents against neurodegenerative disease. Here, we investigated the influence of CA on microbiota-gut-brain axis in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mice. The results demonstrated that oral pretreatments of CA significantly prevented the MPTP-indued motor disorders, death of nigrostriatal dopaminergic neurons and reduction in striatal neurotrophins. Sequencing results of 16S rRNA indicated the microbial dysbiosis occurred in MPTP mice, whereas CA exerted a remarkable impact on microbial diversity and microbiota compositions, as well as SCFAs production. Besides, CA pretreatment alleviated gliosis-mediated neuroinflammation and gut inflammation by suppressing TLR4/MyD88/NF-?5;B signaling cascade, along with preventing the colonic hyperpermeability. To conclude, CA prevented MPTP-induced neuroinflammation and neuronal degenerative processes through signaling multiple pathways of microbiota-gut-brain axis.

scholarly journals The Methods of Detection of Gait Disturbance and Postural Instability in Case of Parkinson’s Disease

2018 ◽  
Vol 3 (2) ◽  
pp. 37-40
Author(s):  
IE E Poverennova ◽  
VA A Kalinin ◽  
SA A Shpileva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scales ◽  
Rating Scale ◽  
Neurological Diseases ◽  
Freezing Of Gait ◽  
Postural Instability ◽  
Motor Disorders ◽  
Medication Therapy ◽  
Disease Rating

Parkinson’s disease takes first place among neurological diseases of senior persons and its prevalence consists of 2% among people elderly than 65 years old. Disturbance of gait and postural instability are the most important motor disorders in case of Parkinson’s disease. Aim - to reveal factors which influence on the falling down of patients with Parkinson’s disease. Materials and methods. The use of unified Parkinson’s disease rating scale for examination of patients with Parkinson’s disease was performed. Results of rating scales were analyzed due to regression analysis. Results. It was revealed that the most important factor of falling down is the disturbance of gait. Freezing of gait has little influence on falling. Conclusion. The use of such diagnostic tests in the routine neurological examination allows to optimize medication therapy and to use modern non- medication methods of correction of gait.

Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease

2012 ◽  
Vol 27 (5) ◽  
pp. 617-626 ◽  
Author(s):  
Ronald B. Postuma ◽  
Dag Aarsland ◽  
Paolo Barone ◽  
David J. Burn ◽  
Christopher H. Hawkes ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Disorders
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