scholarly journals Atypical lymphoid hyperplasia of cervix with clonal IGH/IGK and BCL6 gene rearrangements

Pathology ◽  
2020 ◽  
Author(s):  
Katrina Lancaster-Shorts ◽  
James O. Armitage ◽  
Timothy Greiner ◽  
Kai Fu ◽  
Ji Yuan
Keyword(s):  
Lymphoid Hyperplasia ◽  
Gene Rearrangements ◽  
Atypical Lymphoid Hyperplasia

Infliximab‐related atypical lymphoid hyperplasia mimicking primary cutaneous lymphoma of the ear

2020 ◽  
Author(s):  
Gabriela Pita da Veiga ◽  
José Manuel Suárez‐Peñaranda ◽  
Noelia Moreiras‐Arias ◽  
Hugo Vázquez‐Veiga ◽  
Dolores Sánchez‐Aguilar
Keyword(s):  
Lymphoid Hyperplasia ◽  
Cutaneous Lymphoma ◽  
Atypical Lymphoid Hyperplasia ◽  
Primary Cutaneous Lymphoma

Primary Colorectal Follicular Lymphoma in 3 Dogs

2019 ◽  
Vol 56 (3) ◽  
pp. 404-408
Author(s):  
Michael A. Richardson ◽  
Tuddow Thaiwong ◽  
Matti Kiupel
Keyword(s):  
Follicular Lymphoma ◽  
Clinical Signs ◽  
Case Series ◽  
Lymphoid Hyperplasia ◽  
Lymphoid Cells ◽  
Rectal Mass ◽  
Atypical Lymphoid Hyperplasia ◽  
Polymerase Chain ◽  
Multicentric Lymphoma ◽  
Follicular Lymphomas

Primary colorectal follicular lymphomas are rare indolent lymphoid neoplasms in humans that have not been reported in dogs. We describe 3 cases of primary colorectal follicular lymphoma in dogs with histologic and immunohistochemical features similar to their human counterpart. Initial clinical signs in all dogs included tenesmus, hematochezia, and a palpable rectal mass. Two dogs were castrated males and 1 an intact female, between 9 months and 2 years of age, and of varied breeds. All 3 cases of colorectal follicular lymphoma were characterized by proliferation of follicular germinal centers with no polarity or mantle zone and were composed of centrocytes admixed with fewer centroblasts. By immunohistochemistry, lymphoid cells expressed CD20, BCL2, and BCL6 and lacked expression of CD3, CD5, and cyclin D1. Polymerase chain reaction for rearrangements of the immunoglobulin heavy chain confirmed a monoclonal population in all cases. In 2 of the 3 cases, a solitary nodular colorectal mass was excised and appeared curative; however, the third case had multiple colorectal masses and the animal developed multicentric lymphoma. This case series immunohistochemically characterizes and distinguishes colorectal follicular lymphoma from atypical lymphoid hyperplasia.

Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysis

Blood ◽  
1989 ◽  
Vol 73 (6) ◽  
pp. 1635-1645 ◽  
Author(s):  
DM Knowles ◽  
E Athan ◽  
A Ubriaco ◽  
L McNally ◽  
G Inghirami ◽  
...  
Keyword(s):  
B Cell ◽  
Malignant Lymphoma ◽  
Dna Sequences ◽  
Lymphoid Hyperplasia ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
Immunoglobulin Gene ◽  
Lymphoid Neoplasms ◽  
Benign Lymphoid Hyperplasia ◽  
Ebv Dna

We investigated 16 lymphoid proliferations occurring in the ocular adnexa, salivary glands, breast, and thyroid gland and satisfying the histopathologic and immunophenotypic criteria of benign lymphoid hyperplasia for the presence of clonal rearrangements of the antigen receptor, c-myc, bcl-1, and bcl-2 genes and Epstein-Barr virus (EBV) DNA sequences. Each of these 16 extranodal, noncutaneous lymphoid neoplasms exhibited clonal immunoglobulin heavy and/or light chain and lacked T-cell receptor (TCR) beta-chain gene rearrangements. The patterns of immunoglobulin gene rearrangements included solitary and multiple barely perceptible to faint bands, solitary clear and definite bands, and solitary high-intensity bands superimposed on a background of multiple less-intense bands. Three ocular adnexal lymphoid neoplasms exhibited bcl-1 or bcl-2 gene rearrangements. None of the 16 lymphoid neoplasms contained EBV DNA sequences. Two patients developed a histopathologically confirmed malignant lymphoma in an extranodal site. None of the remaining 14 patients developed additional lymphoid neoplasms during a mean follow-up period of 30 months, despite conservative therapy. These results demonstrate that extranodal, noncutaneous lymphoid neoplasms meeting the histopathologic and immunophenotypic criteria for benign lymphoid hyperplasia frequently contain occult monoclonal and oligoclonal B-cell populations representing a continuous and progressive spectrum of B-cell neoplasia up to and including malignant lymphoma.

Novel therapeutic option for orbital atypical lymphoid hyperplasia

2010 ◽  
Vol 38 (9) ◽  
pp. 892-894 ◽  
Author(s):  
Dipti Talaulikar ◽  
David Tridgell ◽  
David Leong ◽  
Jane E Dahlstrom ◽  
Maya Cherian ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Lymphoid Hyperplasia ◽  
Atypical Lymphoid Hyperplasia ◽  
Novel Therapeutic

Atypical lymphoid hyperplasia of the eyelids manifesting as xanthelasma-like lesions

1997 ◽  
Vol 37 (5) ◽  
pp. 839-842 ◽  
Author(s):  
Conleth A. Egan ◽  
Bhupendra C.K. Patel ◽  
Ricardo Morschbacher ◽  
John W. Gerwels ◽  
Richard L. Anderson
Keyword(s):  
Lymphoid Hyperplasia ◽  
Atypical Lymphoid Hyperplasia

scholarly journals Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysis

Blood ◽  
1989 ◽  
Vol 73 (6) ◽  
pp. 1635-1645 ◽  
Author(s):  
DM Knowles ◽  
E Athan ◽  
A Ubriaco ◽  
L McNally ◽  
G Inghirami ◽  
...  
Keyword(s):  
B Cell ◽  
Malignant Lymphoma ◽  
Dna Sequences ◽  
Lymphoid Hyperplasia ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
Immunoglobulin Gene ◽  
Lymphoid Neoplasms ◽  
Benign Lymphoid Hyperplasia ◽  
Ebv Dna

Abstract We investigated 16 lymphoid proliferations occurring in the ocular adnexa, salivary glands, breast, and thyroid gland and satisfying the histopathologic and immunophenotypic criteria of benign lymphoid hyperplasia for the presence of clonal rearrangements of the antigen receptor, c-myc, bcl-1, and bcl-2 genes and Epstein-Barr virus (EBV) DNA sequences. Each of these 16 extranodal, noncutaneous lymphoid neoplasms exhibited clonal immunoglobulin heavy and/or light chain and lacked T-cell receptor (TCR) beta-chain gene rearrangements. The patterns of immunoglobulin gene rearrangements included solitary and multiple barely perceptible to faint bands, solitary clear and definite bands, and solitary high-intensity bands superimposed on a background of multiple less-intense bands. Three ocular adnexal lymphoid neoplasms exhibited bcl-1 or bcl-2 gene rearrangements. None of the 16 lymphoid neoplasms contained EBV DNA sequences. Two patients developed a histopathologically confirmed malignant lymphoma in an extranodal site. None of the remaining 14 patients developed additional lymphoid neoplasms during a mean follow-up period of 30 months, despite conservative therapy. These results demonstrate that extranodal, noncutaneous lymphoid neoplasms meeting the histopathologic and immunophenotypic criteria for benign lymphoid hyperplasia frequently contain occult monoclonal and oligoclonal B-cell populations representing a continuous and progressive spectrum of B-cell neoplasia up to and including malignant lymphoma.

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