scholarly journals 23. P53 IN BARRETT’S oesophagus with changes indefinite for dysplasia

Pathology ◽  
2020 ◽  
Vol 52 ◽  
pp. S141
Author(s):  
G. Miller ◽  
I. Brown
Keyword(s):  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus ◽  
Indefinite For Dysplasia

scholarly journals Mutational load may predict risk of progression in patients with Barrett’s oesophagus and indefinite for dysplasia: a pilot study

2019 ◽  
Vol 6 (1) ◽  
pp. e000268 ◽  
Author(s):  
Arvind J Trindade ◽  
Matthew J McKinley ◽  
Mohammad Alshelleh ◽  
Gabriel Levi ◽  
Molly Stewart ◽  
...  
Keyword(s):  
Pilot Study ◽  
Risk Stratification ◽  
High Grade Dysplasia ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
High Grade ◽  
Mutational Load ◽  
Barrett's Oesophagus ◽  
Risk Of Progression ◽  
Indefinite For Dysplasia

Background and aimsMutational load (ML) has been shown to help risk-stratify those that may progress from non-dysplastic Barrett’s oesophagus (BE) to dysplastic disease. Management of patients with BE and indefinite for dysplasia (BE-IND) is challenging and risk stratification tools are lacking. The aim of this pilot study is to evaluate the utility of ML for risk stratification in patients with BE-IND.MethodsThis is a single-centre, retrospective pilot study evaluating ML quantification in patients with BE-IND. Histology at follow-up endoscopy at least 1 year after the baseline endoscopy was used to determine if a patient progressed to low or high dysplasia. The ML levels were then compared among patients who progressed to dysplasia versus those who did not.ResultsThirty-five patients who met the inclusion criteria were identified, and seven met the exclusion criteria. Twenty-eight patients were analysed, of whom eight progressed to low-grade dysplasia (6) and high-grade dysplasia (2). Seven of these eight patients had some level of genomic instability detected in their IND biopsy (ML ≥0.5). Ten of the 20 (50%) who did not progress had no ML level. At an ML cut-off above 1.5, the risk of progression to high-grade dysplasia was 33% vs 0% (p=0.005), with a sensitivity of 100% and a specificity of 85%.ConclusionThese results indicate that ML may be able to risk-stratify progression to high-grade dysplasia in BE-IND. Larger studies are needed to confirm these findings.

Human and murine data suggest critical role for TGF-β in the aetiopathogenesis of Barrett's oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A415-A415
Author(s):  
R FITZGERALD ◽  
B ONWUEGBUSI ◽  
G DEPAULO ◽  
R FEAKINS ◽  
L MCKINNEY ◽  
...  
Keyword(s):  
Critical Role ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

ENDOSCOPIC RESECTION OF LOW GRADE DYSPLASIA IN BARRETT’S OESOPHAGUS: A RETROSPECTIVE STUDY ABOUT 61 PATIENTS

2020 ◽  
Author(s):  
Fabrice Caillol ◽  
Arthur Falque ◽  
Margherita Pizzicannella ◽  
Christian Pesenti ◽  
Jean Philippe Ratone ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Endoscopic Resection ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
Barrett's Oesophagus ◽  
Low Grade Dysplasia
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