Initial presentation of acute myeloid leukaemia as collision intradermal melanocytic naevus and myeloid leukaemia cutis mimicking naevoid melanoma

Pathology ◽  
2019 ◽  
Vol 51 (4) ◽  
pp. 441-443
Author(s):  
Laurence Galea ◽  
Chin-Guan Tan ◽  
Peter I.A. McQuillan ◽  
Sant Khan ◽  
Christopher Mow
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Initial Presentation ◽  
Melanocytic Naevus ◽  
Acute Myeloid

scholarly journals Myeloid Sarcoma of the Orbit Preceding Acute Myeloid Leukaemia: A Diagnostic Challenge

2019 ◽  
Vol 11 (14) ◽  
pp. 98
Author(s):  
Oluomachi Charity Nnachi ◽  
Robert Azu Nnachi ◽  
Innocent Paul Ezenwenyi ◽  
Ogah Emeka Onwe ◽  
Augustine Ejike Okoye ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Condition ◽  
Tumour Progression ◽  
Correct Diagnosis ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Orbital Mass ◽  
Management Of Complications ◽  
Acute Myeloid

Objective: Myeloid sarcoma is a rare form of acute myeloid leukaemia characterized by extramedullary proliferation of myeloid blasts which can occur as an isolated lesion in any organ. Even rarer it may occur in the orbit as the initial presentation without a leukaemic phase and diagnosis may be challenging when it is not suspected.           Methods: We report a case of orbital myeloid sarcoma as the initial presentation of acute myeloid leukaemia in an adult who was misdiagnosed and treated as a case of a pseudotumour with resultant significant disease progression and worsening of the clinical condition. There was a lag of four months from the onset of eye mass to the development of acute myeloid leukaemia. Result: Due to patients worsening condition and tumour progression, a repeat biopsy for a second histology opinion at a different facility, immunophenotyping and immunohistochemistry were employed to arrive at the correct diagnosis. Following chemotherapy, the orbital mass reduced markedly and clinical condition improved. The patient was indigent and could not sustain further funding of his treatment because he had already spent much on for management of complications he developed before a definitive diagnosis could be made. Conclusion: Myeloid sarcoma can present as an orbital mass without a leukemic disease. Therefore a high index of suspicion, meticulous examination of biopsy, immunohistochemistry and collaboration between oncologists and ophthalmologists, are required to arrive at an early accurate diagnosis.

scholarly journals Cholecystitis as the initial presentation of acute myeloid leukaemia

2016 ◽  
Vol 176 (3) ◽  
pp. 344-344 ◽  
Author(s):  
Arjun Gupta ◽  
Avash Das ◽  
Harris V. K. Naina
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Initial Presentation ◽  
Acute Myeloid

The acute myeloid leukaemia market

2019 ◽  
Vol 19 (4) ◽  
pp. 233-234
Author(s):  
Jorrit Schaefer ◽  
Sorcha Cassidy ◽  
Rachel M. Webster
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Myeloid
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