Induction of peripheral lymph node addressin in human nasal mucosa with eosinophilic chronic rhinosinusitis

Pathology ◽  
2019 ◽  
Vol 51 (3) ◽  
pp. 268-273 ◽  
Author(s):  
Toshiki Tsutsumiuchi ◽  
Hitomi Hoshino ◽  
Shigeharu Fujieda ◽  
Motohiro Kobayashi
Keyword(s):  
Lymph Node ◽  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Peripheral Lymph Node ◽  
Human Nasal Mucosa ◽  
Peripheral Lymph ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals Characterization of a human homologue of the murine peripheral lymph node homing receptor.

1989 ◽  
Vol 109 (1) ◽  
pp. 421-427 ◽  
Author(s):  
B R Bowen ◽  
T Nguyen ◽  
L A Lasky
Keyword(s):  
Cell Adhesion ◽  
Lymph Node ◽  
Adhesion Molecule ◽  
Carbohydrate Binding ◽  
Human Homologue ◽  
Peripheral Lymph Node ◽  
Homing Receptor ◽  
Lymph Node Homing ◽  
Peripheral Lymph ◽  
Human Receptor

Lymphocyte trafficking is a fundamental aspect of the immune system that allows B and T lymphocytes with diverse antigen recognition specificities to be exposed to various antigenic stimuli in spatially distinct regions of an organism. A lymphocyte adhesion molecule that is involved with this trafficking phenomenon has been termed the homing receptor. Previous work (Lasky, L., T. Yednock, M. Singer, D. Dowbenko, C. Fennie, H. Rodriguez, T. Nguyen, S. Stachel, and S. Rosen. 1989. Cell. 56:1045-1055) has characterized a cDNA clone encoding a murine homing receptor that is involved in trafficking of lymphocytes to peripheral lymph nodes. This molecule was found to contain a number of protein motifs, the most intriguing of which was a carbohydrate binding domain, or lectin, that is apparently involved in the adhesive interaction between murine lymphocytes and peripheral lymph node endothelium. In this study, we have used the murine cDNA clone to isolate a human homologue of this peripheral lymph node-specific adhesion molecule. The human receptor was found to be highly homologous to the murine receptor in overall sequence, but showed no sequence similarity to another surface protein that may be involved with human lymphocyte homing, the Hermes glycoprotein. The extracellular region of the human receptor contained an NH2 terminally located carbohydrate binding domain followed by an EGF-like domain and a domain containing two repeats of a complement binding motif. Transient cell transfection assays using the human receptor cDNA showed that it encoded a surface glycoprotein that cross reacted with a polyclonal antibody directed against the murine peripheral lymph node homing receptor. Interestingly, the human receptor showed a high degree of sequence homology to another human cell adhesion glycoprotein, the endothelial cell adhesion molecule ELAM.

scholarly journals Epidemiology of Peripheral Lymph Node Tuberculosis and Genotyping of M. tuberculosis Strains: A Case-Control Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132400 ◽  
Author(s):  
Chinmay Khandkar ◽  
Zinta Harrington ◽  
Peter J. Jelfs ◽  
Vitali Sintchenko ◽  
Claudia C. Dobler
Keyword(s):  
Lymph Node ◽  
Case Control Study ◽  
Case Control ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Tuberculosis ◽  
Control Study

scholarly journals Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes.

1989 ◽  
Vol 109 (5) ◽  
pp. 2463-2469 ◽  
Author(s):  
J S Geoffroy ◽  
S D Rosen
Keyword(s):  
Lymph Node ◽  
Lymphoid Organ ◽  
Lymphoid Organs ◽  
Surface Glycoprotein ◽  
Lymphocyte Migration ◽  
Peripheral Lymph Node ◽  
Adhesive Interaction ◽  
High Endothelial Venules ◽  
Cell Surface Glycoprotein ◽  
Peripheral Lymph

Lymphocyte migration from the blood into most secondary lymphoid organs is initiated by a highly selective adhesive interaction with the endothelium of specialized blood vessels known as high endothelial venules (HEV). The propensity of lymphocytes to migrate to particular lymphoid organs is known as lymphocyte homing, and the receptors on lymphocytes that dictate interactions with HEV at particular anatomical sites are designated "homing receptors". Based upon antibody blockade experiments and cell-type distribution studies, a prominent candidate for the peripheral lymph node homing receptor in mouse is the approximately 90-kD cell surface glycoprotein (gp90MEL) recognized by the monoclonal antibody MEL-14. Previous work, including sequencing of a cDNA encoding for this molecule, supports the possibility that gp90MEL is a calcium-dependent lectin-like receptor. Here, we show that immunoaffinity-purified gp90MEL interacts in a sugar-inhibitable manner with sites on peripheral lymph node HEV and prevents attachment of lymphocytes. Lymphocyte attachment to HEV in Peyer's patches, a gut-associated lymphoid organ, is not affected by gp90MEL. The results demonstrate that gp90MEL, as a lectin-like receptor, directly bridges lymphocytes to the endothelium.

Detection of Surfactant Proteins A, B, C, and D in Human Nasal Mucosa and Their Regulation in Chronic Rhinosinusitis with Polyps

2013 ◽  
Vol 27 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Martin Schicht ◽  
Stephan Knipping ◽  
Roman Hirt ◽  
Stephanie Beileke ◽  
Saadettin Sel ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Surfactant Proteins ◽  
Human Nasal Mucosa

scholarly journals Recombinant anti-monkey CD3 immunotoxin depletes peripheral lymph node T lymphocytes more effectively than rabbit anti-thymocyte globulin in naïve baboons

2013 ◽  
Vol 29 (1-4) ◽  
pp. 60-63 ◽  
Author(s):  
Isaac Wamala ◽  
Abraham J. Matar ◽  
Evan Farkash ◽  
Zhirui Wang ◽  
Christene A. Huang ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Lymphocytes ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph
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