Unfractionated heparin monitoring with activated partial thromboplastin time – RCPAQAP questionnaire review

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S121-S122
Author(s):  
Sandya Arunachalam ◽  
Fernando Estepa ◽  
Peter Graham
Keyword(s):  
Unfractionated Heparin ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Heparin Monitoring

Interlaboratory variation in heparin monitoring: Lessons from the Quality Management Program of Ontario coagulation surveys

2010 ◽  
Vol 104 (10) ◽  
pp. 837-844 ◽  
Author(s):  
Anne Raby ◽  
Karen Moffat ◽  
Greg Flynn ◽  
Mark Crowther ◽  
Adam Cuker
Keyword(s):  
Quality Management ◽  
Unfractionated Heparin ◽  
Human Plasma ◽  
Coefficient Of Variation ◽  
Partial Thromboplastin Time ◽  
Management Program ◽  
Activated Partial Thromboplastin Time ◽  
Heparin Concentration ◽  
Laboratory Services ◽  
Heparin Monitoring

SummaryUnfractionated heparin (UFH) monitoring is subject to substantial inter-laboratory variation. We analysed results of annual coagulation surveys administered by the Quality Management Program – Laboratory Services (Toronto, ON, Canada) from 2003 to 2007 to evaluate variation in UFH monitoring across Ontario. Participating laboratories performed an activated partial thromboplastin time (APTT) utilising their local methodology on lyophilised human plasma spiked with UFH. In the 2006 and 2007 surveys, laboratories licensed to perform anti-Xa assays also reported anti-Xa activity results. The APTT differed significantly between heparin-sensitive and heparin-insensitive methods (p<0.0005). Within-method variation was observed and increased with increasing heparin concentration. Among laboratories performing an APTT and anti-Xa, the coefficient of variation was greater in the anti-Xa than in the APTT for both the 2006 (64.0% vs. 10.5%) and 2007 (15.0% vs. 11.6%) surveys. Substantial interlaboratory variation in UFH monitoring, both between and within APTT methods, was observed and was not reduced by use of an anti-Xa assay.

Impact of a Nurse-Driven Heparin Monitoring Protocol for Ventricular Assist Devices

2021 ◽  
Vol 32 (2) ◽  
pp. 146-151
Author(s):  
Michelle Gannon ◽  
Pamela B. Simone
Keyword(s):  
Unfractionated Heparin ◽  
Partial Thromboplastin Time ◽  
Heparin Therapy ◽  
Activated Partial Thromboplastin Time ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Monitoring Protocol ◽  
Monitoring Protocols ◽  
Heparin Monitoring

Background: Ventricular assist devices require anticoagulation to reduce thrombosis risk. Nurse-driven unfractionated heparin monitoring protocols have been validated for various indications, although data in patients with ventricular assist devices are lacking. Objective: To evaluate a nurse-driven protocol for managing unfractionated heparin therapy in stable patients with ventricular assist devices. Methods: This was a retrospective analysis of adult patients with ventricular assist devices requiring unfractionated heparin therapy, divided into 2 groups: before and after protocol implementation. The primary outcome was time to first therapeutic activated partial thromboplastin time. Results: Each group included 29 patients. There was no difference between the preintervention and postintervention groups in time to therapeutic activated partial thromboplastin time (25 vs 23 hours, P = .95) or proportion of patients with therapeutic activated partial thromboplastin time within the first 24 hours (45% vs 34%, P = .42). Suspected pump thrombosis and bleeding events were similar in the 2 groups. Conclusion: A nurse-driven heparin monitoring protocol was similar in time to therapeutic activated partial thromboplastin time compared with provider-driven monitoring and adjustments in patients with ventricular assist devices.

scholarly journals Monitoring of Unfractionated Heparin Using Activated Partial Thromboplastin Time

2013 ◽  
Vol 20 (7) ◽  
pp. 723-728 ◽  
Author(s):  
Je Sang Kim ◽  
Hyun Jong Lee ◽  
Ji Dong Sung ◽  
Hee-Jin Kim ◽  
Soo-Youn Lee ◽  
...  
Keyword(s):  
Unfractionated Heparin ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time

scholarly journals Clinical outcomes with unfractionated heparin monitored by anti‐factor Xa vs. activated partial Thromboplastin time

2019 ◽  
Vol 94 (9) ◽  
pp. 1015-1019 ◽  
Author(s):  
James C. Coons ◽  
Carlo J. Iasella ◽  
Megan Thornberg ◽  
Mary Grace Fitzmaurice ◽  
Kimberly Goehring ◽  
...  
Keyword(s):  
Unfractionated Heparin ◽  
Clinical Outcomes ◽  
Partial Thromboplastin Time ◽  
Factor Xa ◽  
Activated Partial Thromboplastin Time

Effect of Subcutaneous Unfractionated Heparin Prophylaxis on Activated Partial Thromboplastin Time

2017 ◽  
Vol 61 (1) ◽  
pp. 20
Author(s):  
M. H. Thompson ◽  
S. H. Wilson ◽  
B. L. Toussaint ◽  
C. L. Jordan ◽  
G. L. Hayes ◽  
...  
Keyword(s):  
Unfractionated Heparin ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Heparin Prophylaxis
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