Pathological re-classification of basal cell carcinomas from the ontrac skin cancer chemoprevention study and the new who skin blue book

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S8
Author(s):  
Catriona A. McKenzie ◽  
Richard A. Scolyer ◽  
Diona L. Damian
Keyword(s):  
Skin Cancer ◽  
Basal Cell ◽  
Cancer Chemoprevention ◽  
Blue Book ◽  
Basal Cell Carcinomas

scholarly journals Medical images classification for skin cancer using quantitative image features with optical coherence tomography

2016 ◽  
Vol 09 (02) ◽  
pp. 1650003 ◽  
Author(s):  
Wei Gao ◽  
Valery P. Zakharov ◽  
Oleg O. Myakinin ◽  
Ivan A. Bratchenko ◽  
Dmitry N. Artemyev ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Cancer ◽  
Basal Cell ◽  
Image Features ◽  
Skin Tumors ◽  
P Value ◽  
Optical Coherence ◽  
Quantitative Image ◽  
Basal Cell Carcinomas

Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractal-based features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of [Formula: see text][Formula: see text]0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas and pigment nevi as compared with melanomas. Significant decrease of contrast, entropy and fractal dimension was also observed in basal cell carcinomas and pigment nevi as compared with melanomas. Our results suggest that the selected quantitative image features of OCT images could provide useful information to differentiate basal cell carcinomas and pigment nevi from the melanomas. Further research is warranted to determine how this approach may be used to improve the classification of skin tumors.

scholarly journals Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

2012 ◽  
Vol 87 (2) ◽  
pp. 212-219 ◽  
Author(s):  
Pedro Andrade ◽  
Maria Manuel Brites ◽  
Ricardo Vieira ◽  
Angelina Mariano ◽  
José Pedro Reis ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Neoplasms ◽  
Squamous Cell Carcinomas ◽  
Exposed Skin ◽  
Non Melanoma Skin Cancer ◽  
Basal Cell Carcinomas ◽  
Malignant Skin ◽  
Melanoma Skin

BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.

scholarly journals Initial basal cell carcinomas diagnosed in the National Campaign for Skin Cancer Prevention are smaller than those identified by the conventional medical referral system

2017 ◽  
Vol 92 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Thweicyka Pinheiro Wakiyama ◽  
◽  
Maria Laura Marconi França ◽  
Larissa Pierri Carvalho ◽  
Mariangela Esther Alencar Marques ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Prevention ◽  
Basal Cell ◽  
Skin Cancer Prevention ◽  
Referral System ◽  
Basal Cell Carcinomas ◽  
Medical Referral

Topical cytotoxic drugs for skin cancer

1968 ◽  
Vol 6 (14) ◽  
pp. 55-56
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Grafting ◽  
Cytotoxic Drugs ◽  
Cure Rate ◽  
Basal Cell Carcinomas ◽  
Multiple Basal Cell Carcinomas ◽  
Epidermal Carcinoma ◽  
Methods Of Treatment

The main types of primary skin cancer are basal-cell carcinoma (rodent ulcer), intra-epidermal carcinoma (Bowen’s disease) and squamous-cell carcinoma. In Britain surgery and radiotherapy are the commonly used methods of treating these conditions. Both methods have a high cure rate, over 95%, but both also have some drawbacks. Surgery may require admission to hospital, general anaesthesia and skin grafting; radiotherapy requires special facilities, and can occasionally cause troublesome scarring. Radiotherapy is often undesirable, and surgery not always practical for patients with multiple basal cell carcinomas such as are found after many years’ exposure to sunlight, and those with the basal cell naevus syndrome. Other methods of treatment worth considering include curettage and cautery, which can give excellent results,1 and topical use of cytotoxic drugs.

Subsequent Squamous- and Basal-Cell Carcinomas in Kidney-Transplant Recipients After the First Skin Cancer: Cumulative Incidence and Risk Factors

2010 ◽  
Vol 89 (10) ◽  
pp. 1231-1238 ◽  
Author(s):  
Hermina C. Wisgerhof ◽  
Jeroen R. J. Edelbroek ◽  
Johan W. de Fijter ◽  
Geert W. Haasnoot ◽  
Frans H. J. Claas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Skin Cancer ◽  
Kidney Transplant ◽  
Basal Cell ◽  
Cumulative Incidence ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Basal Cell Carcinomas

Somatic Mutations in TP53 Gene in Colombian Patients With Non-melanoma Skin Cancer

2022 ◽  
Vol 2 (1) ◽  
pp. 107-114
Author(s):  
LUZ DARY GUTIÉRREZ-CASTAÑEDA ◽  
JOHN NOVA ◽  
MARÍA IRENE CEREZO-CORTÉS
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Somatic Mutations ◽  
Tp53 Gene ◽  
Non Melanoma Skin Cancer ◽  
Basal Cell Carcinomas ◽  
Frequent Mutations ◽  
Melanoma Skin

Background/Aim: Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer. Materials and Methods: One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing. Results: Fifty-seven patients with basal cell carcinomas and 58 with squamous cell carcinomas were studied. 16% of patients with basal cell carcinoma and 26% of patients with squamous cell carcinoma had mutations in the TP53 gene. The most frequent mutations were substitutions, while three patients had deletions. The most frequent mutation was p.R158G. Conclusion: The analysis showed that Colombian individuals with non-melanoma skin cancer have genetic TP53 variants different from those reported as recurrent for this disease.

Metastasizing Auricular Basal Cell Carcinoma

1980 ◽  
Vol 88 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Richard C. Bryarly ◽  
Stephen R. Veach ◽  
Alan D. Kornblut
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Radical Surgery ◽  
Palliative Therapy ◽  
Basal Cell Carcinomas ◽  
Neck Area ◽  
Common Skin

Basal cell carcinoma represents the most common skin cancer and involves the head and neck area in 80% to 85% of all patients treated. Despite their frequent occurrence, metastatic spread from these tumors is rare. This paper presents a case of a patient who had a metastasizing basal cell carcinoma. Despite control of primary disease by radical surgery and adjunctive irradiation, bony metastasis was found within nine months of therapy. Palliative therapy was given, but the patient died five months later. The pathophysiology of the metastasizing basal cell carcinomas is described, and a rationale for therapy presented.

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