Combined hepatocellular carcinoma and high grade neuroendocrine carcinoma with EWSR1 gene rearrangement

Pathology ◽  
2018 ◽  
Vol 50 (7) ◽  
pp. 779-782 ◽  
Author(s):  
Khoon Leong Chuah ◽  
Brendan Pang ◽  
Diana Lim ◽  
Chi Kuen Lee ◽  
Cora Yuk-Ping Chau
Keyword(s):  
Hepatocellular Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Gene Rearrangement ◽  
High Grade ◽  
Ewsr1 Gene

Mixed Hepatocellular Carcinoma, Neuroendocrine Carcinoma of the Liver

2016 ◽  
Vol 82 (11) ◽  
pp. 1121-1125 ◽  
Author(s):  
Erin Baker ◽  
Carl Jacobs ◽  
John Martinie ◽  
David A. Iannitti ◽  
Dionisios Vrochides ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Gene Mutations ◽  
Lateral Lobe ◽  
Cell Types ◽  
High Grade ◽  
Large Tumor ◽  
Pathologic Features ◽  
Platinum Based Chemotherapy ◽  
Biomarker Analysis

We present the case of a 76-year-old male found to have a large tumor involving the left lateral lobe of the liver, presumed to be hepatocellular carcinoma (HCC). After resection, pathologic features demonstrated both high-grade HCC and high-grade neuroendocrine carcinoma (NEC). Areas of NEC stained strongly for synaptophysin, which was not present in HCC component. The HCC component stained strongly for Hep-Par 1, which was not present in the NEC component. The patient underwent genetic analysis for biomarkers common to both tumor cell types. Both tumor components contained gene mutations in CTNNB1 gene (S33F located in exon 3). They also shared mutations in PD-1, PGP, and SMO. Mixed HCC/NEC tumors have been rarely reported in the literature with generally poor outcomes. This patient has been referred for adjuvant platinum-based chemotherapy; genetic biomarker analysis may provide some insight to guide targeted chemotherapy.

Soft tissue myoepithelial carcinoma without EWSR1 gene rearrangement and poor outcome. A case report

2012 ◽  
Vol 45 (1) ◽  
pp. 58-63 ◽  
Author(s):  
María Auxiliadora Aparicio ◽  
Fernando López-Barea ◽  
Juan Jesús Cruz ◽  
María del Carmen García Macías ◽  
Teresa Hernández ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Gene Rearrangement ◽  
Myoepithelial Carcinoma ◽  
Poor Outcome ◽  
Ewsr1 Gene

Radiation Therapy for High-Grade Neuroendocrine Carcinoma of the Rectum and Anal Canal

2014 ◽  
Vol 90 (1) ◽  
pp. S394
Author(s):  
K. Voong ◽  
A. Rashid ◽  
C.H. Crane ◽  
B.D. Minsky ◽  
S. Krishnan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Anal Canal ◽  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Rectum

Therapeutic approaches and outcomes in patients with larynx or hypopharynx high‐grade neuroendocrine carcinoma: A s ingle‐center retrospective analysis

Head & Neck ◽  
2021 ◽  
Author(s):  
Luana Guimaraes Sousa ◽  
Felippe Lazar Neto ◽  
Danice Karagiannis Torman ◽  
Eduardo M. Diaz ◽  
David I. Rosenthal ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Therapeutic Approaches

scholarly journals Esophageal neuroendocrine carcinoma presenting as a rare cause of dysphagia

2018 ◽  
Vol 5 (2) ◽  
pp. 1
Author(s):  
Sylvester Luu ◽  
Brian C. Benson ◽  
Kelly A. Haeusler ◽  
Robert O. Brady ◽  
Katherine M. Cebe ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Gastroesophageal Junction ◽  
Prior History ◽  
High Grade ◽  
Active Smoking ◽  
Platinum Based Chemotherapy ◽  
History Of ◽  
Neuroendocrine Carcinomas

A 60-year-old male with prior history of laryngeal carcinoma and active smoking presented with six months of solid food dysphagia. Endoscopy showed a large, friable gastroesophageal junction mass. Biopsies revealed a high-grade, poorlydifferentiated neuroendocrine carcinoma. He was subsequently started on platinum based chemotherapy and radiation therapy and his tumor decreased dramatically in size. This case is unique as neuroendocrine carcinomas (NECs) are rarely found in the esophagus and usually have a poor prognosis at time of diagnosis.

scholarly journals Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1338
Author(s):  
Tiberiu-Augustin Georgescu ◽  
Roxana Elena Bohiltea ◽  
Octavian Munteanu ◽  
Florentina Furtunescu ◽  
Antonia-Carmen Lisievici ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
Classification System ◽  
Who Classification ◽  
Small Cell ◽  
International Agency ◽  
Low Grade ◽  
High Grade ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Female Genital

Neuroendocrine neoplasms (NENs) are particularly rare in all sites of the gynecological tract and include a variety of neoplasms with variable prognosis, dependent on histologic subtype and site of origin. Following the expert consensus proposal of the International Agency for Research on Cancer (IARC), the approach in the latest World Health Organization (WHO) Classification System of the Female Genital Tumours is to use the same terminology for NENs at all body sites. The main concept of this novel classification framework is to align it to all other body sites and make a clear distinction between well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The previous WHO Classification System of the Female Genital Tumours featured more or less the same principle, but used the terms ‘low-grade neuroendocrine tumor’ and ‘high-grade neuroendocrine carcinoma’. Regardless of the terminology used, each of these two main categories include two distinct morphological subtypes: NETs are represented by typical and atypical carcinoid and NEC are represented by small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC). High-grade NECs, especially small cell neuroendocrine carcinoma tends to be more frequent in the uterine cervix, followed by the endometrium, while low-grade NETs usually occur in the ovary. NENs of the vulva, vagina and fallopian tube are exceptionally rare, with scattered case reports in the scientific literature.

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