MDM2/CDK4 gene amplification in large/deep-seated ‘lipomas’: incidence, predictors and clinical significance

Pathology ◽  
2016 ◽  
Vol 48 (3) ◽  
pp. 203-209 ◽  
Author(s):  
Daniel D. Wong ◽  
Irene C. Low ◽  
Joanne Peverall ◽  
Peter D. Robbins ◽  
Dominic V. Spagnolo ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Gene Amplification ◽  
Cdk4 Gene

scholarly journals Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5690-5702 ◽  
Author(s):  
Li-Jie Ma ◽  
Fei-Ling Feng ◽  
Liang-Qing Dong ◽  
Zhao Zhang ◽  
Meng Duan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Gene Amplification

Gnathic giant-cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification

2017 ◽  
Vol 70 (7) ◽  
pp. 1171-1173 ◽  
Author(s):  
Katsutoshi Hirose ◽  
Masaya Okura ◽  
Sunao Sato ◽  
Shumei Murakami ◽  
Jyun-Ichiro Ikeda ◽  
...  
Keyword(s):  
Giant Cell ◽  
Gene Amplification ◽  
Conventional Osteosarcoma ◽  
Cdk4 Gene

Common alternative gene alterations in adult malignant astrocytomas, but not in childhood primitive neuroectodermal tumors: P16ink4 homozygous deletions and CDK4 gene amplifications

1996 ◽  
Vol 84 (6) ◽  
pp. 1020-1023 ◽  
Author(s):  
Joseph Petronio ◽  
Ju He ◽  
Daniel Fults ◽  
Carolyn Pedone ◽  
C. David James ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Content Type ◽  
Primitive Neuroectodermal Tumors ◽  
Malignant Astrocytomas ◽  
Neuroectodermal Tumors ◽  
Cdk4 Gene ◽  
Homozygous Deletions ◽  
Gene Alterations

✓ Alterations in P16ink4 or in the gene encoding one of its ligands, cyclin-dependent kinase 4 (CDK4), have been reported in human glioma cell lines and primary tumors but not in primitive neuroectodermal tumors (PNETs), the most common malignant brain tumor of childhood. In this study the authors have examined DNA from 20 primary PNETs in children and from 20 malignant astrocytomas to assess the frequency of P16ink4 and CDK4 gene alterations associated with each type of tumor. Southern hybridization analysis revealed homozygous P16ink4 deletions in one (5%) of 20 PNETs and in seven (35%) of 20 malignant astrocytomas. The CDK4 gene amplification was evident in two additional astrocytomas, but not in any of the PNETs. In total, nine astrocytomas (45%) exhibited homozygous P16ink4 deletion or CDK4 gene amplification, but only one PNET (5%) demonstrated either gene alteration. These results indicate that the incidence of P16ink4 and CDK4 gene alterations in these two groups of tumors is different and suggest distinct pathogenetic etiologies may be associated with each neoplasm.

hTERT Gene Amplification and Clinical Significance in Pleural Effusions of Patients With Lung Cancer

2012 ◽  
Vol 13 (6) ◽  
pp. 494-499 ◽  
Author(s):  
Na Cha ◽  
Xiao-Yan Li ◽  
Yu-Jie Zhao ◽  
En-Hua Wang ◽  
Guang-Ping Wu
Keyword(s):  
Lung Cancer ◽  
Clinical Significance ◽  
Gene Amplification ◽  
Pleural Effusions ◽  
Htert Gene
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