Validation of a phospholipase A2 receptor antibody ELISA in an Australian cohort with membranous glomerulonephritis

Pathology ◽  
2016 ◽  
Vol 48 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Lawrence Ong ◽  
Roger Silvestrini ◽  
Jeremy Chapman ◽  
David A. Fulcher ◽  
Ming Wei Lin
Keyword(s):  
Phospholipase A2 ◽  
Membranous Glomerulonephritis ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor ◽  
Australian Cohort ◽  
Antibody Elisa

scholarly journals Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy

2018 ◽  
Vol 37 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Eun Joo Song ◽  
Kye Hwa Jeong ◽  
Young Ae Yang ◽  
Jeong-Hoon Lim ◽  
Hee-Yeon Jung ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Prognostic Marker ◽  
Membranous Nephropathy ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor

scholarly journals FP131ANTI-PHOSPHOLIPASE A2 RECEPTOR ANTIBODY MEASURED BY ELISA AS A PROGNOSTIC FACTOR IN PATIENTS WITH IDIOPATHIC MEMBRATNOUS NEPHROPATHY

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii111-iii111
Author(s):  
Yang Gyun Kim ◽  
Young-Wook Choi ◽  
Jin Sug Kim ◽  
Yu Ho Lee ◽  
Kyung-Hwan Jeong ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Phospholipase A2 ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor

scholarly journals Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A2 receptor antibody-positive membranous nephropathy

2012 ◽  
Vol 5 (2) ◽  
pp. 162-165 ◽  
Author(s):  
S. Surindran ◽  
R. Ayalon ◽  
N. Hasan ◽  
L. H. Beck ◽  
D. J. Salant ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor

scholarly journals Phospholipase A2 receptor staining is absent in many kidney biopsies with early-stage membranous glomerulonephritis

2016 ◽  
Vol 89 (6) ◽  
pp. 1402-1403 ◽  
Author(s):  
Margaret S. Ryan ◽  
Anjali A. Satoskar ◽  
Gyongyi M. Nadasdy ◽  
Sergey V. Brodsky ◽  
Jessica A. Hemminger ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Early Stage ◽  
Membranous Glomerulonephritis ◽  
Phospholipase A2 Receptor

scholarly journals Anti-phospholipase A2 receptor antibody in membranous nephropathy; an Indian experience

2017 ◽  
Vol 7 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Monika Yachha ◽  
Raj Kumar Sharma ◽  
Sonia Mehrotra ◽  
Narayan Prasad ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Receptor Antibody ◽  
Indian Experience ◽  
Phospholipase A2 Receptor

scholarly journals Successful foetal outcome in a patient with primary membranous nephropathy and circulating anti-phospholipid antibodies: A case report

2018 ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Membranous Glomerulonephritis ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Phospholipase A2 Receptor ◽  
Foetal Outcome ◽  
Circulating Autoantibodies ◽  
Patient’S History

There is little information about pregnancy outcomes in patients with active membranous nephropathy (MN), especially those with circulating autoantibodies to M-type phospholipase A2 receptor (PLA2R), the major autoantigen in primary MN. Membranous glomerulonephritis (MGN) represents an immunologically mediated disease characterized by deposition of immune complexes in the glomerular subepithelial space, frequently associated with circulating M-type phospholipase A2 receptor. Nephrotic syndrome (massive proteinuria and hypoalbuminemia) at diagnosis predicts poor prognosis. Pregnancy with active MGN is high risk for foetal loss, intrauterine growth restriction, and pre-eclampsia, and may worsen maternal renal function, especially with the presence of antiphospholipid antibody syndrome (APLA). We report a 23-year-old gravida in her first pregnancy, suffering from MGN and severe nephrotic syndrome, complicated by APLA syndrome. The patient was treated with enoxaparin, aspirin azathioprine, and Prednisone for a short time, in addition to furosemide and albumin intravenously. She was delivered at 30 weeks due to deteriorating maternal and foetal conditions. A successful neonatal and maternal outcome was achieved in this case. The patient's history revealed thrombocytopenia and APLA syndrome and continues to be treated chronically with enoxaparin. Kidney biopsy performed after delivery showed membranous MGN stage II-III. Herein, we present a case of successful pregnancy and foetal outcome in a young woman with APLA syndrome and MN. Keywords: Membranous GN, Nephrotic Syndrome, Anti-Phospholipid Antibodies.

Sign in / Sign up

Export Citation Format

Share Document