Pediatric Liver Tumors

2020 ◽  
Vol 13 (4) ◽  
pp. 601-623
Author(s):  
Soo-Jin Cho
Keyword(s):  
Liver Tumors ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors

Outcomes of Central Hepatectomy for Pediatric Liver Tumors

2021 ◽  
Vol 268 ◽  
pp. 570-575
Author(s):  
Stephanie Y Chen ◽  
Abigail K Zamora ◽  
Danny Lascano ◽  
Shengmei Zhou ◽  
Eugene S Kim ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors ◽  
Central Hepatectomy

scholarly journals HEPATOBLASTOMA: 5-YEAR RETROSPECTIVE STUDY. PEDIATRIC ONCOLOGICAL SURGERY SERVICE “GENERAL ONCOLOGY HOSPITAL.SOLÓN ESPINOSA AYALA” SOLCA QUITO- ECUADOR

2019 ◽  
pp. 1-2
Author(s):  
Alexánder Antonio Jara Chávez ◽  
Carolina Vanessa Saldaña Rodríguez ◽  
Silvana Jeannett Suarez Merchan ◽  
Juan Reyes Villacreses ◽  
Víctor Alfonso Terán Pérez ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Liver Tumors ◽  
Multidisciplinary Treatment ◽  
Primary Diagnosis ◽  
Demographic Variables ◽  
Second Primary ◽  
Adequate Treatment ◽  
Pediatric Liver ◽  
Specialized Center ◽  
Pediatric Liver Tumors

Objectives: Describe the demographic variables, types of liver tumor, surgeries performed and survival children diagnosed with liver tumor undergoing surgical treatment.Method: A retrospective analysis was performed in patients with pediatric liver tumors undergoing surgical treatment, from January 2010 to December 2015 at the "General Oncology Hospital. Solon Espinoza Ayala”. Results: Data from our study reported a diagnosis of hepatoblastoma in 51.85% of all pediatric liver tumors; 50% are routine controls without evidence of disease, 14.28% have been completed clinical treatment, 21.42% died from a second primary diagnosis with metastasis, and another 14.28% (only surgery) who were not followed up because they were transfers from another health system; with respect to global survival it was 64%. The ages ranged from 0 to 15 years old with an average of 5.5. Conclusion: It is very important a timely detection and adequate treatment by a specialized center and trained professionals, liver surgery is a very important chapter for the treatment of liver tumors. The surgical approach with tumor-free resection along with multidisciplinary treatment is the goal for healing.

Pathology of Pediatric Liver Tumors

2010 ◽  
pp. 83-112 ◽  
Author(s):  
Arthur Zimmermann ◽  
Dolores Lopez-Terrada
Keyword(s):  
Liver Tumors ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors

132Liver transplantation for pediatric liver tumors

2000 ◽  
Vol 6 (3) ◽  
pp. C33-C33
Author(s):  
J BUELL ◽  
A YOSHIDA ◽  
S LIMSCIMCHREM ◽  
S KELLEY ◽  
P BOONE ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors

ETOPOSIDE, CISPLATIN, EPIRUBICIN CHEMOTHERAPY IN THE TREATMENT OF PEDIATRIC LIVER TUMORS

2005 ◽  
Vol 22 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Michela Casanova ◽  
Maura Massimino ◽  
Andrea Ferrari ◽  
Filippo Spreafico ◽  
Luigi Piva ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors

Pediatric liver tumors: Initial presentation, image finding and outcome

2007 ◽  
Vol 49 (4) ◽  
pp. 491-496 ◽  
Author(s):  
JIAAN-DER WANG ◽  
TE-KAU CHANG ◽  
HOU-CHUAN CHEN ◽  
SHENG-LING JAN ◽  
FANG-LIANG HUANG ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Initial Presentation ◽  
Image Finding ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors

scholarly journals Genetic and epigenetic basis of hepatoblastoma diversity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Genta Nagae ◽  
Shogo Yamamoto ◽  
Masashi Fujita ◽  
Takanori Fujita ◽  
Aya Nonaka ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Fetal Liver ◽  
Intestinal Epithelial ◽  
Cell Of Origin ◽  
Liver Malignancy ◽  
Pediatric Liver ◽  
Pediatric Liver Tumors ◽  
Molecular Aberrations ◽  
Methylation Patterns ◽  
Promoter Mutations

AbstractHepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and nine hepatocellular carcinomas) based on the data acquired from a cohort study (JPLT-2). The total number of somatic mutations is precious low (0.52/Mb on exonic regions) but correlated with age at diagnosis. Telomerase reverse transcriptase (TERT) promoter mutations are prevalent in the tween HBs, selective in the transitional liver cell tumor (TLCT, > 8 years old). DNA methylation profiling reveals that classical HBs are characterized by the specific hypomethylated enhancers, which are enriched with binding sites for ASCL2, a regulatory transcription factor for definitive endoderm in Wnt-pathway. Prolonged upregulation of ASCL2, as well as fetal-liver-like methylation patterns of IGF2 promoters, suggests their “cell of origin” derived from the premature hepatoblast, similar to intestinal epithelial cells, which are highly proliferative. Systematic molecular profiling of HB is a promising approach for understanding the epigenetic drivers of hepatoblast carcinogenesis and deriving clues for risk stratification.

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