Non-neoplastic Pathology in Tumor Nephrectomy Specimens

2014 ◽  
Vol 7 (3) ◽  
pp. 291-305 ◽  
Author(s):  
Vanesa Bijol ◽  
Ibrahim Batal
Keyword(s):  
Tumor Nephrectomy

scholarly journals More than ancillary records: clinical implications of renal pathology examination in tumor nephrectomy specimens

2021 ◽  
Author(s):  
Johannes Philipp Kläger ◽  
Ahmad Al-Taleb ◽  
Mladen Pavlovic ◽  
Andrea Haitel ◽  
Eva Comperat ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Renal Pathology ◽  
Vascular Lesions ◽  
Renal Tumors ◽  
Renal Diseases ◽  
Tumor Type ◽  
Neoplastic Tissue ◽  
Cell Renal Cell Carcinoma ◽  
Hypertensive Nephropathy ◽  
Tumor Nephrectomy

Abstract Background Nephrectomy is the management of choice for the treatment of renal tumors. Surgical pathologists primarily focus on tumor diagnosis and investigations relating to prognosis or therapy. Pathological changes in non-neoplastic tissue may, however, be relevant for further management and should be thoroughly assessed. Methods Here, we examined the non-neoplastic renal parenchyma in 206 tumor nephrectomy specimens for the presence of glomerular, tubulo-interstitial, or vascular lesions, and correlated them with clinical parameters and outcome of renal function. Results We analyzed 188 malignant and 18 benign or pseudo-tumorous lesions. The most common tumor type was clear cell renal cell carcinoma (CCRCC, n = 106) followed by papillary or urothelial carcinomas (n = 25). Renal pathology examination revealed the presence of kidney disease in 39 cases (18.9%). Glomerulonephritis was found in 15 cases (7.3%), and the most frequent was IgA nephropathy (n = 6; 2.9%). Vasculitis was found in two cases (0.9%). In 15 cases we found tubulo-interstitial nephritis, and in 9 severe diabetic or hypertensive nephropathy. Partial nephrectomy was not linked to better eGFR at follow-up. Age, vascular nephropathy, glomerular scarring and interstitial fibrosis were the leading independent negative factors influencing eGFR at time of surgery, whereas proteinuria was associated with reduced eGFR at 1 year. Conclusion Our large study population indicates a high incidence of renal diseases potentially relevant for the postoperative management of patients with renal neoplasia. Consistent and systematic reporting of non-neoplastic renal pathology in tumor nephrectomy specimens should therefore be mandatory.

Higher incidence of surgery-related complications in Wilms tumor nephrectomy from clinical records analysis compared with central database registration

2018 ◽  
Vol 66 (2) ◽  
pp. e27502
Author(s):  
Daan van Poll ◽  
Jim Wilde ◽  
Kees van de Ven ◽  
Maria Asimakidou ◽  
Hugo Heij ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Tumor Nephrectomy ◽  
Central Database ◽  
Clinical Records

323 Serum and urine biomarker profile of kidney injury after (partial) tumor nephrectomy

2014 ◽  
Vol 13 (1) ◽  
pp. e323 ◽  
Author(s):  
J. Langetepe ◽  
M. Schmid ◽  
B. Schwaiger ◽  
R. Tahbaz ◽  
S.A. Ahyai ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Tumor Nephrectomy ◽  
Urine Biomarker ◽  
Serum And Urine

scholarly journals Nonneoplastic Renal Cortical Scarring at Tumor Nephrectomy Predicts Decline in Kidney Function

2013 ◽  
Vol 137 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Steven P. Salvatore ◽  
Eugene K. Cha ◽  
James S. Rosoff ◽  
Surya V. Seshan
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Interstitial Fibrosis ◽  
Prognostic Significance ◽  
Preoperative Assessment ◽  
Tubular Atrophy ◽  
Hypertensive Nephropathy ◽  
Tumor Nephrectomy ◽  
End Stage

Context.—Evaluating nontumor portions of tumor nephrectomies is useful to diagnose nonneoplastic renal disease. Objective.—To determine the medical renal disease frequency and to assess the prognostic significance of the various renal pathologic variables with long-term follow-up in tumor nephrectomy patients. Design.—We reviewed nonneoplastic kidney sections of 456 consecutive cases from 1998 to 2008. Seventy-five cases were excluded (19 tumor compression, 25 no nonneoplastic tissue, 22 embolized kidneys, 9 end stage). Special staining, immunofluorescence, and/or electron microscopy was performed where appropriate. Vascular sclerosis was scored from mild to severe; interstitial fibrosis/tubular atrophy and global glomerulosclerosis (GS) were expressed as percentages. Follow-up, minimum 12 months, was evaluated in 156 cases. All renal pathologic variables were compared with regard to change in creatinine level from preoperative assessment to follow-up. Results.—Of 381 cases, 57 had additional medical renal disease (15%), most frequently diabetic nephropathy (28) and hypertensive nephropathy (11). Postoperative creatinine levels increased significantly in patients with severe arteriosclerosis or arteriolosclerosis, >5% GS, and >10% interstitial fibrosis/tubular atrophy. Seventy-four percent of cases with additional nonneoplastic diagnoses showed severe arteriolosclerosis. Higher corresponding GS was seen in the more affected vascular cases: mean, 5.56% GS for mild versus 23% GS for severe. Three patients progressed to renal failure 1 to 4 years after nephrectomy, 2 with hypertensive nephrosclerosis and 1 with diabetic nephropathy. Conclusions.—Medical renal disease was identified in 15% of tumor nephrectomy specimens. The degrees of vascular sclerosis, GS, and interstitial fibrosis/tubular atrophy are predictive of elevated creatinine levels in postnephrectomy patients. Prognostic implications of the nontumor pathology are important in nephrectomized patients.

UP-01.164 Serum Cystatin C: A Marker of Early Kidney Function Damage After Tumor Nephrectomy?

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S241
Author(s):  
M. Schmid ◽  
W. Tenschert ◽  
B. Schwaiger ◽  
F. Chun ◽  
M. Fisch
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Tumor Nephrectomy

The Non-neoplastic Kidney in Tumor Nephrectomy Specimens

2010 ◽  
Vol 17 (4) ◽  
pp. 235-250 ◽  
Author(s):  
Stephen M. Bonsib ◽  
Ying Pei
Keyword(s):  
Tumor Nephrectomy

Evaluation of the Nonneoplastic Pathology in Tumor Nephrectomy Specimens

2006 ◽  
Vol 30 (5) ◽  
pp. 575-584 ◽  
Author(s):  
Vanesa Bijol ◽  
Gonzalo P. Mendez ◽  
Shelley Hurwitz ◽  
Helmut G. Rennke ◽  
V??nia Nos??
Keyword(s):  
Tumor Nephrectomy

scholarly journals Renin gene expression in human kidney biopsies from patients with glomerulonephritis or graft rejection.

1995 ◽  
Vol 5 (7) ◽  
pp. 1469-1475
Author(s):  
J Wagner ◽  
S Volk ◽  
C C Haufe ◽  
A Ciechanowicz ◽  
M Paul ◽  
...  
Keyword(s):  
Gene Expression ◽  
Graft Rejection ◽  
Enzyme Inhibitor ◽  
Quantitative Polymerase Chain Reaction ◽  
Internal Standard ◽  
Human Kidney ◽  
Endogenous Gene ◽  
Tumor Nephrectomy ◽  
Renin Gene ◽  
Renin Mrna

The expression of renin mRNA was determined by a quantitative polymerase chain reaction assay in 27 human kidney samples: (1) 15 biopsies of patients with glomerulonephritis with or without angiotensin-converting enzyme inhibitor (ACEI) treatment; (2) biopsies of six renal allografts with graft rejection; and (3) six biopsy samples from unaffected parts of tumor nephrectomy specimens as controls. After isolation of RNA, 0.5 to 1 microgram of total RNA was used for reverse transcription to generate cDNA. The human renin gene was subsequently amplified by the use of two primers spanning the second and third exons. Renin expression was quantified with a renin cDNA mutant as the internal standard. It exhibited the same primer binding sites as the endogenous gene but carried a 155-basepair deletion, thus yielding a shorter amplification product. The number of glomeruli was counted by microscopic transillumination immediately after biopsy (median, 9 per biopsy; range, 2 to 23). Renin mRNA was expressed as femtograms of renin mRNA per glomerulus. Renin gene expression was lower in glomerulonephritic patients without ACEI treatment compared with that in control tumor nephrectomy samples, i.e., 63 +/- 20 (N = 7) versus 250 +/- 50 fg (N = 6) of renin mRNA/glomerulus, (P < 0.02), although plasma renin concentration in the glomerulonephritic patients was in the normal range. Significantly higher renin mRNA expression was found in glomerulonephritic patients treated with ACEI, i.e., 210 +/- 50 (N = 8) compared with 63 +/- 20 (N = 7) fg of renin mRNA/glomerulus in patient not treated with ACEI (P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals The pathological evaluation of nonneoplastic kidney disorder in tumor nephrectomy specimens

2018 ◽  
Vol 29 (3) ◽  
pp. 586
Author(s):  
Sina Dindarian ◽  
Farahnaz Noroozinia ◽  
Khadijeh Makhdoomi ◽  
Hamid Behnamfard ◽  
Sedra Mohammadi ◽  
...  
Keyword(s):  
Kidney Disorder ◽  
Tumor Nephrectomy ◽  
Pathological Evaluation
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