Menadione (vitamin K3) inhibits hydrogen sulfide and substance P via NF-кB pathway in caerulein-induced acute pancreatitis and associated lung injury in mice

Pancreatology ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Amiti ◽  
Ramasamy Tamizhselvi ◽  
Venkatraman Manickam
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Sulfide ◽  
Substance P ◽  
Lung Injury ◽  
Vitamin K3

scholarly journals Hydrogen Sulfide Up-Regulates Substance P in Polymicrobial Sepsis-Associated Lung Injury

2007 ◽  
Vol 179 (6) ◽  
pp. 4153-4160 ◽  
Author(s):  
Huili Zhang ◽  
Akhil Hegde ◽  
Siaw Wei Ng ◽  
Sharmila Adhikari ◽  
Shabbir M. Moochhala ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Substance P ◽  
Lung Injury ◽  
Polymicrobial Sepsis

Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury

2003 ◽  
Vol 284 (5) ◽  
pp. G830-G836 ◽  
Author(s):  
Madhav Bhatia ◽  
John Slavin ◽  
Yuqing Cao ◽  
Allan I. Basbaum ◽  
John P. Neoptolemos
Keyword(s):  
Acute Pancreatitis ◽  
Substance P ◽  
Lung Injury ◽  
Gene Deletion ◽  
Gene Products ◽  
Nk1 Receptors ◽  
Proinflammatory Mediators ◽  
Pancreatic Damage ◽  
Impaired Lung Function ◽  
Nk2 Receptor

Impaired lung function in severe acute pancreatitis is the primary cause of morbidity and mortality in this condition. Preprotachykinin-A (PPT-A) gene products substance P and neurokinin (NK)-A have been shown to play important roles in neurogenic inflammation. Substance P acts primarily (but not exclusively) via the NK1 receptor. NKA acts primarily via the NK2 receptor. Earlier work has shown that knockout mice deficient in NK1 receptors are protected against acute pancreatitis and associated lung injury. NK1 receptors, however, bind other peptides in addition to substance P, not all of which are derived from the PPT-A gene. To examine the role of PPT-A gene products in acute pancreatitis, the effect of PPT-A gene deletion on the severity of acute pancreatitis and the associated lung injury was investigated. Deletion of PPT-A almost completely protected against acute pancreatitis-associated lung injury, with a partial protection against local pancreatic damage. These results show that PPT-A gene products are critical proinflammatory mediators in acute pancreatitis and the associated lung injury.

T1301 Serum Hydrogen Sulfide and Substance P Are Early Clinical Predictors of the Severity of Acute Pancreatitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-543
Author(s):  
Eric WL Wee ◽  
Madhav Bhatia ◽  
Mark L. Fernandes ◽  
Krishnakumar Madhavan ◽  
Jennie Y. Wong ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Sulfide ◽  
Substance P ◽  
Clinical Predictors

Role of hydrogen sulfide in acute pancreatitis and associated lung injury

2005 ◽  
Vol 19 (6) ◽  
pp. 1-17 ◽  
Author(s):  
Madhav Bhatia ◽  
Fei Ling Wong ◽  
Di Fu ◽  
Hon Yen Lau ◽  
Shabbir M. Moochhala ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Sulfide ◽  
Lung Injury

scholarly journals Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

2021 ◽  
Vol 22 (22) ◽  
pp. 12136
Author(s):  
Ayush Kumar ◽  
Madhav Bhatia
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Sulfide ◽  
Substance P ◽  
Adhesion Molecules ◽  
Inflammatory Disease ◽  
Cell Adhesion Molecules ◽  
Tissue Injury ◽  
Gastrointestinal Disorders ◽  
Natural Response

Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H2S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H2S, substance P and adhesion molecules play in acute pancreatitis.

scholarly journals Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury

1998 ◽  
Vol 95 (8) ◽  
pp. 4760-4765 ◽  
Author(s):  
M. Bhatia ◽  
A. K. Saluja ◽  
B. Hofbauer ◽  
J.-L. Frossard ◽  
H. S. Lee ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Substance P ◽  
Lung Injury ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1
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