Characterization of IGF2BP proteins in pancreatic neuroendocrine neoplasms

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S43-S44
Author(s):  
Florian Sperling ◽  
Lars Nietfeld ◽  
Katharina Theuerkorn ◽  
Sebastian Krug ◽  
Heidi Griesmann ◽  
...  
Keyword(s):  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms

Abstract PR-009: Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

2020 ◽  
Author(s):  
Kevin C. Yang ◽  
Steve Kalloger ◽  
John Aird ◽  
Michael Lee ◽  
Christopher Rushton ◽  
...  
Keyword(s):  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms

scholarly journals Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

Cell Reports ◽  
2021 ◽  
Vol 37 (2) ◽  
pp. 109817
Author(s):  
Kevin C. Yang ◽  
Steve E. Kalloger ◽  
John J. Aird ◽  
Michael K.C. Lee ◽  
Christopher Rushton ◽  
...  
Keyword(s):  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms

Digital Subtraction of Magnetic Resonance Images Improves Detection and Characterization of Pancreatic Neuroendocrine Neoplasms

2017 ◽  
Vol 41 (4) ◽  
pp. 614-618 ◽  
Author(s):  
Riccardo De Robertis ◽  
Paolo Tinazzi Martini ◽  
Sara Cingarlini ◽  
Silvia Ortolani ◽  
Giovanni Butturini ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Images ◽  
Neuroendocrine Neoplasms ◽  
Digital Subtraction ◽  
Pancreatic Neuroendocrine Neoplasms

Multifocal Pancreatic Neuroendocrine Neoplasms In Tuberous Sclerosis: A Rare Case

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S77-S77
Author(s):  
N C Jadhav ◽  
D L Gang
Keyword(s):  
Tuberous Sclerosis ◽  
Neurofibromatosis Type ◽  
Abdominal Ultrasound ◽  
Biologically Active ◽  
Pancreatic Tumors ◽  
Neuroendocrine Neoplasms ◽  
Ki 67 ◽  
Pancreatic Neuroendocrine Neoplasms ◽  
Von Hippel Lindau ◽  
Multifocal Disease

Abstract Casestudy: Pancreatic neuroendocrine neoplasms (PanNEN) are rare accounting for 2-5% of pancreatic tumors. Although mostly sporadic, 10-20% are associated with inherited syndromes, notably MEN-1, Von Hippel- Lindau disease, neurofibromatosis type 1, and tuberous sclerosis (TS). When compared to sporadic cases, PanNEN in hereditary syndromes occur at a younger age, are often multifocal, cystic, and may show characteristic microscopic patterns. TS is an autosomal dominant multi-system disorder with mutations involving TSC1 or TSC2 genes which function as tumor suppressors by inhibiting mTORC1 kinase. PanNEN is observed in 1.5-1.8% of patients with TS and no surveillance guidelines for the assessment of pancreatic lesions are established. Compared to other syndromes, PanNEN associated with TS are solitary. To our knowledge, only two cases of multifocal PanNEN in TS patients have been reported. We present a case of a 67-year-old gentleman with a history of TS also affecting two daughters. He presented to the emergency department with severe abdominal pain. Abdominal ultrasound suggested acute appendicitis and an incidental 2.0 cm solid lesion was noted in the head of the pancreas. Follow-up MRI revealed two additional non-cystic masses in the pancreatic tail. Endoscopic ultrasound-guided biopsy of a tail lesion revealed monomorphic tumor cells with stippled chromatin without cytologic atypia. Immunohistochemical staining was positive for synaptophysin and chromogranin. Ki-67 labelling index was under 1%. Diagnosis of a well-differentiated neuroendocrine tumor (G1) was made. The patient denied symptoms of the carcinoid syndrome and no biologically active hormones were detected. Gallium PET scan revealed multiple foci of radiotracer uptake throughout the pancreas in addition to those described on MRI. Although PanNEN are rare in TS, malignant behavior has been reported. This case reinforces the importance of early detection through active surveillance, especially as surgical options may be limited in multifocal disease.

Systematic review of current prognostication systems for pancreatic neuroendocrine neoplasms

Surgery ◽  
2019 ◽  
Vol 165 (4) ◽  
pp. 672-685 ◽  
Author(s):  
Roxanne Y.A. Teo ◽  
Timothy Z. Teo ◽  
David W.M. Tai ◽  
Damien M. Tan ◽  
Simon Ong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms
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