Carbon ion beam combined with chemotherapy distroys pancreatic cancer stem cells

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S168
Author(s):  
Cui Xing
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Ion Beam ◽  
Carbon Ion ◽  
Carbon Ion Beam ◽  
Pancreatic Cancer Stem Cells

scholarly journals Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions

2021 ◽  
Vol Volume 14 ◽  
pp. 4749-4760
Author(s):  
Sei Sai ◽  
Eun Ho Kim ◽  
Woong Sub Koom ◽  
Guillaume Vares ◽  
Masao Suzuki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Ion Beam ◽  
Beam Irradiation ◽  
Ion Beam Irradiation ◽  
Carbon Ion Beam ◽  
Pancreatic Cancer Stem Cells

scholarly journals Effects of Carbon Ion Beam on Putative Colon Cancer Stem Cells and Its Comparison with X-rays

2011 ◽  
Vol 71 (10) ◽  
pp. 3676-3687 ◽  
Author(s):  
Xing Cui ◽  
Kazuhiko Oonishi ◽  
Hirohiko Tsujii ◽  
Takeshi Yasuda ◽  
Yoshitaka Matsumoto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Ion Beam ◽  
X Rays ◽  
Carbon Ion ◽  
Colon Cancer Stem Cells ◽  
Carbon Ion Beam

scholarly journals Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

2015 ◽  
Vol 34 (5) ◽  
pp. 2233-2237 ◽  
Author(s):  
SUNG-JAE BAEK ◽  
HIDESHI ISHII ◽  
KEISUKE TAMARI ◽  
KAZUHIKO HAYASHI ◽  
NAOHIRO NISHIDA ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Ion Beam ◽  
Beam Radiation ◽  
Carbon Ion ◽  
Carbon Ion Beam

scholarly journals Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Di Carlo ◽  
Bebiana C. Sousa ◽  
Marcello Manfredi ◽  
Jessica Brandi ◽  
Elisa Dalla Pozza ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Fatty Acid ◽  
Cancer Stem Cells ◽  
Acyl Chain ◽  
Fatty Acid Elongase ◽  
Acyl Chains ◽  
A Chain ◽  
Pancreatic Cancer Stem Cells ◽  
Long Chain

AbstractPancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common proteome and lipidome modulations. PCSCs displayed downregulation of lactate dehydrogenase A chain, and upregulation of trifunctional enzyme subunit alpha. The upregulated proteins of PCSCs are mainly involved in fatty acid (FA) elongation and biosynthesis of unsaturated FAs. Accordingly, lipidomics reveals an increase in long and very long-chain unsaturated FAs, which are products of fatty acid elongase-5 predicted as a key gene. Moreover, lipidomics showed the induction in PCSCs of molecular species of cardiolipin with mixed incorporation of 16:0, 18:1, and 18:2 acyl chains. Our data indicate a crucial role of FA elongation and alteration in cardiolipin acyl chain composition in PCSCs, representing attractive therapeutic targets in PDAC.

206 Identification and Whole Transcriptome Characterization of Pancreatic Cancer Stem Cells

2012 ◽  
Vol 142 (5) ◽  
pp. S-50-S-51
Author(s):  
Christina Vorvis ◽  
George A. Poultsides ◽  
Jeffrey A. Norton ◽  
Maria Hatziapostolou ◽  
Dimitrios Iliopoulos
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Whole Transcriptome ◽  
Pancreatic Cancer Stem Cells
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