Impact of surgical treatment for recurrent pancreatic cancer after curative pancreatectomy

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S100
Author(s):  
Atsushi Miyamoto ◽  
Naoki Hama ◽  
Sakae Maeda ◽  
Mamoru Uemura ◽  
Kazuyoshi Yamamoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Recurrent Pancreatic Cancer

Resection of Recurrent Pancreatic Cancer: Who Can Benefit?

2021 ◽  
pp. 1-7
Author(s):  
Henrik Nienhüser ◽  
Markus W. Büchler ◽  
Martin Schneider
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Median Overall Survival ◽  
Improve Patient Selection ◽  
Significant Survival ◽  
Recurrent Pancreatic Cancer ◽  
Disseminated Disease ◽  
Improve Patient ◽  
Initial Resection ◽  
Related Mortality

<b><i>Background:</i></b> Recurrence after resection of pancreatic cancer occurs in up to 80% of patients in the first 2 years after complete resection. While most patients are not eligible for surgical treatment due to disseminated disease, a certain group of patients can be evaluated for re-resection of local recurrence. This review summarizes the current literature on surgical treatment of recurrent pancreatic cancer and potential prognostic factors. <b><i>Summary:</i></b> Re-resection of recurrent pancreatic cancer provides a significant survival benefit to selected patients with acceptable procedure-related mortality. Median overall survival after re-resection of recurrent pancreatic cancer is up to 28 months. The most relevant clinical parameters associated with a prognostic benefit are young patient age (&#x3c;65 years), time to initial resection (&#x3e;10 months), and preoperative chemotherapy before re-resection. Molecular markers are currently under investigation and might help to improve patient selection in the future. <b><i>Key Message:</i></b> Re-resection of recurrent pancreatic cancer is safe and feasible in experienced hands. Selected patients benefit from surgical treatment, but future studies are needed to identify reliable prognostic markers predicting survival.

RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH CHRONIC PANCREATITIS AND THE RISK OF CANCER AFTER SURGICAL TREATMENT

2018 ◽  
Vol 64 (2) ◽  
pp. 228-233
Author(s):  
Vladimir Lubyanskiy ◽  
Vasiliy Seroshtanov ◽  
Ye. Semenova
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Surgical Treatment ◽  
Fibrous Tissue ◽  
Pancreatic Head ◽  
Head Region ◽  
Intestinal Anastomoses ◽  
Resection Of The Pancreas ◽  
Risk Of Cancer

The aim: To analyze results of surgical treatment of patients with chronic pancreatitis (CP) and to assess the causes of pancreatic cancer after surgical treatment. Materials and methods: 137 patients had duodenum-preserving resections of the pancreas. Results: In the histological examination of the pancreas it was established that the growth of fibrous tissue was registered in patients with CP., which in 19 (13.8%) almost completely replaced the acinar tissue. In the long term after the operation from 6 months to 2 years in 8 patients (5.8%) pancreatic cancer was detected. Possible causes of tumor origin were analyzed, the value of preservation of ductal hypertension, which affects the state of the duct’s epithelium, was established. The most commonly used for treatment of chronic pancreatitis the Frey surgery removed pancreatic hypertension but in two patients during the operation an insufficient volume of the pancreatic head was reconstructed. In the case of the abandonment of a large array of fibrous tissue, local hypertension was retained in the region of the ductal structures of the head, which led to the transformation of the duct epithelium. An essential factor in the problem of the preservation of pancreatic hypertension were the stenosis of pancreatic intestinal anastomoses, they arose in the long term in 4 operated patients. With stenosis of anastomosis after duodenum-preserving resection both the hypertension factor and the regeneration factor could be realized, which under certain circumstances might be significant. Conclusion: After resection of the pancreas for CP cancer was diagnosed in 5.8% of patients. The main method of preventing the risk of cancer was performing the Frey surgery for CP eliminating pancreatic hypertension in the head region of the pancreas. Diagnosis of stenosis in the late period after resection of the pancreas was an important element in the prevention of recurrence of cancer since a timely reconstructive operation could improve the drainage of duct structures.

scholarly journals MO31-1 Surgical treatment for pulmonary oligometastases in the patients with pancreatic cancer who underwent pancreatectomy

2021 ◽  
Vol 32 ◽  
pp. S318
Author(s):  
Maeda Shingo ◽  
Ryoji Takada ◽  
Kenji Ikezawa ◽  
Kazuma Daiku ◽  
Yutaro Abe ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Treatment

Surgical treatment of pancreatic cancer: The role of adjuvant and multimodal therapies

2007 ◽  
Vol 33 (7) ◽  
pp. 817-823 ◽  
Author(s):  
J. Kleeff ◽  
C.W. Michalski ◽  
H. Friess ◽  
M.W. Büchler
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Treatment

Variations in Surgical Treatment and Outcomes of Patients With Pancreatic Cancer: A Population-Based Study

2007 ◽  
Vol 15 (1) ◽  
pp. 175-185 ◽  
Author(s):  
Anand Govindarajan ◽  
Jensen C. C. Tan ◽  
Nancy N. Baxter ◽  
Natalie G. Coburn ◽  
Calvin H. L. Law
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Population Based ◽  
Population Based Study

Completion pancreatectomy for recurrent pancreatic cancer in the remnant pancreas: report of six cases and a review of the literature

2015 ◽  
Vol 400 (8) ◽  
pp. 973-978 ◽  
Author(s):  
Yasuo Shima ◽  
Takehiro Okabayashi ◽  
Akihito Kozuki ◽  
Tatsuaki Sumiyoshi ◽  
Teppei Tokumaru ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Review Of The Literature ◽  
Remnant Pancreas ◽  
Recurrent Pancreatic Cancer ◽  
Completion Pancreatectomy

scholarly journals Patterns of chemotherapy for recurrent pancreatic cancer following resection: A population-level analysis

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e132
Author(s):  
E. Walser ◽  
D. Kagedan ◽  
C. Earle ◽  
Q. Li ◽  
L. Paszat ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Population Level ◽  
Recurrent Pancreatic Cancer ◽  
Level Analysis
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