Serum levels of insulin-like growth factor 1 (IGF-1) and insulin like growth factor binding protein 2 (IGFBP-2) in patients with pancreatic adenocarcinoma (PDAC)

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S90
Author(s):  
Barbara Wlodarczyk ◽  
Anna Borkowska ◽  
Ewa Malecka-Panas ◽  
Anita Gasiorowska
Keyword(s):  
Growth Factor ◽  
Pancreatic Adenocarcinoma ◽  
Binding Protein ◽  
Serum Levels ◽  
Insulin Like Growth Factor ◽  
Factor Binding

SERUM LEVELS OF INSULIN‐LIKE GROWTH FACTOR BINDING PROTEIN‐3 IN BENIGN AND MALIGNANT BREAST DISEASE

1999 ◽  
Vol 69 (7) ◽  
pp. 495-500 ◽  
Author(s):  
I. M. Holdaway ◽  
B. H. Mason ◽  
A. E. Lethaby ◽  
V. Singh ◽  
J. E. Harman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Serum Levels ◽  
Breast Disease ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Malignant Breast

A homologous radioimmunoassay for ovine insulin-like growth factor-binding protein-2: ontogenesis and the response to growth hormone, placental lactogen and insulin-like growth factor-I treatment in sheep

1995 ◽  
Vol 144 (1) ◽  
pp. 75-82 ◽  
Author(s):  
B W Gallaher ◽  
B H Breier ◽  
W F Blum ◽  
S N McCutcheon ◽  
P D Gluckman
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Binding Protein ◽  
Negative Relationship ◽  
Serum Levels ◽  
Treated Group ◽  
Placental Lactogen ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Igf I

Abstract Although insulin-like growth factor-binding protein-2 (IGFBP-2) is an abundant IGFBP in fetal and postnatal plasma, its regulation is not yet clearly understood. To address this question in sheep, we purified ovine IGFBP-2 and developed a homologous radioimmunoassay. We have studied its ontogenesis and measured serum concentrations of ovine IGFBP-2 after bovine growth hormone (bGH), ovine placental lactogen (oPL) and IGF-I treatment. Concentrations of IGFBP-2 were high at 125 days of gestation (550 ± 15 μg/l) but fell after birth P<0·05) and plateaued after 1 year of age (340 ± 20 μg/l). In lactating ewes, bGH treatment for 7 days significantly reduced (21%; P<0·05) IGFBP-2 relative to the saline-treated group. Similarly, in neonatal lambs, bGH treatment from day 3 to day 23 of life reduced (P<0·05) IGFBP-2 by 23% relative to the saline-treated group. oPL had no effect on serum levels of IGFBP-2 in the ewe or the neonatal lamb. In well-fed yearling lambs, treatment with IGF-I reduced IGFBP-2 values by 27% (P<0·05) relative to control animals. In yearling lambs, reduced nutrition increased plasma IGFBP-2 (41%; P<0·05). However this increase was abolished by IGF-I treatment. The changes in plasma levels of IGFBP-2 were positively related to changes in IGF-II while there was a negative relationship between circulating IGF-I and IGFBP-2 such that both IGF-I and IGF-II may play a role in the regulation of IGFBP-2 in serum. Journal of Endocrinology (1995) 144, 75–82

Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3

1994 ◽  
Vol 25 (2) ◽  
pp. 135-148 ◽  
Author(s):  
Dike N. Kalu ◽  
Bahram H. Arjmandi ◽  
Chung-Ching Liu ◽  
Mohammed A. Salih ◽  
Roger S. Birnbaum
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Serum Levels ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Factor I ◽  
Growth Factor I
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