Imipenem prophylaxis for predicted severe acute pancreatitis – Preliminary results of a randomized clinical trial

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S89 ◽  
Author(s):  
Goran Poropat ◽  
Vanja Giljaca ◽  
Vanja Licul ◽  
Goran Hauser ◽  
Sandra Milic ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Randomized Clinical Trial ◽  
Severe Acute Pancreatitis ◽  
Preliminary Results

scholarly journals Early oral refeeding based on hunger in moderate and severe acute pancreatitis: A prospective controlled, randomized clinical trial

Nutrition ◽  
2015 ◽  
Vol 31 (1) ◽  
pp. 171-175 ◽  
Author(s):  
Xian L. Zhao ◽  
Shi F. Zhu ◽  
Gui J. Xue ◽  
Juan Li ◽  
Yi L. Liu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Randomized Clinical Trial ◽  
Severe Acute Pancreatitis

Mo1345 Oral Feeding Versus Nasogastric Feeding in Predicted Severe Acute Pancreatitis: A Randomized Clinical Trial

2015 ◽  
Vol 148 (4) ◽  
pp. S-678-S-679
Author(s):  
Libin Huang ◽  
Zhiyin Huang ◽  
Chunhui Wang ◽  
Jing Li ◽  
Chengwei Tang
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Randomized Clinical Trial ◽  
Severe Acute Pancreatitis ◽  
Oral Feeding ◽  
Nasogastric Feeding

scholarly journals Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Fangyong Yang ◽  
Xiuzhong Qi ◽  
Yiqi Du ◽  
Yan Chen ◽  
Meitang Wang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Randomized Clinical Trial ◽  
Severe Acute Pancreatitis ◽  
Therapeutic Potential ◽  
White Blood Cells ◽  
Control Group ◽  
Peony Root ◽  
Double Blinded ◽  
Experimental Group

The red peony root derived from Paeonia lactiflora has been applied to treat human inflammatory diseases. To investigate its therapeutic potential in treating moderately severe acute pancreatitis (MSAP), which has been rarely studied, this study was designed as a double-blinded, placebo-controlled, randomized clinical trial. A total of 60 MSAP patients were enrolled and randomly divided into an experimental (n = 30) group and a control group (n = 30), who received a coloclyster of 15 g of red peony root or placebo granules dissolved in 150 mL of water, respectively. The patients’ demographic and clinical characteristics were recorded. The results showed that the experimental group had a shorter remission time of fever (p<0.05) and abdominal pain (p<0.01) and faster resumption of self-defecation (p<0.01) than did the control group. In addition, the coloclyster of red peony root decreased the modified Balthazar CT score as well as the serum interleukin-6 and tumor necrosis factor-alpha levels to a greater extent than did the placebo coloclyster (p<0.05). The remission times for the normalization of white blood cells and percentage of neutrophils and lymphocytes in the experimental group were also significantly shorter than those in the control group (p<0.05). In conclusion, a coloclyster of red peony root could help alleviate the clinical symptoms and shorten the course of MSAP by possibly attenuating systematic inflammation. This trial is registered with 14004664.

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