Clinical significance of dynamic monitoring of HLA DR, HLA DR bright, CD14+/CD4+, CD14+/CD16-, CD14+/CD16+ and CD14+/CD56+ monocyte expression in the prediction and evaluation of patients with acute pancreatitis

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S64
Author(s):  
Georgi Minkov ◽  
Yovcho Yovchev ◽  
Krasimira Halacheva ◽  
Maya Gulubova
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Significance ◽  
Dynamic Monitoring ◽  
Hla Dr

scholarly journals Use of surface marker analysis to predict outcome of adult acute myeloblastic leukemia

Blood ◽  
1986 ◽  
Vol 68 (6) ◽  
pp. 1232-1241
Author(s):  
JD Griffin ◽  
R Davis ◽  
DA Nelson ◽  
FR Davey ◽  
RJ Mayer ◽  
...  
Keyword(s):  
T Cell ◽  
Complete Remission ◽  
Clinical Significance ◽  
Total Population ◽  
Cell Lineage ◽  
Antigen Expression ◽  
Acute Myeloblastic Leukemia ◽  
Myeloid Antigens ◽  
Hla Dr ◽  
Surface Marker Analysis

In order to investigate the clinical significance of surface antigen analysis in acute myeloblastic leukemia (AML), the blasts from 196 patients with AML were analyzed prospectively with a panel of 16 monoclonal antibodies. The antibodies were selected to identify differentiation-associated antigens of either the myeloid lineage (MY9, PM-81, AML-2–23, MY7, MCS-1, MY8, Mo1, MY1, MY4, Mo2), T cell lineage (T101, T11), B cell lineage (B1, B4) or multiple lineages [J5 (CALLA), HLA-DR]. Independent morphological review and classification by French- American-British (FAB) criteria was performed in 161 of the 196 cases. One or more myeloid surface antigens were detected on the blasts of 195 cases, while B and T cell markers were detected on 0% to 2% of cases. When both blood and marrow samples were studied on the same patient, very few differences were noted between the antigenic profiles of the paired specimens. The frequency of expression of individual myeloid antigens ranged from 91% (PM-81) to 29% (Mo2). Expression of individual antigens was found to correlate significantly with several clinical parameters including FAB classification, cytochemical staining for alpha naphthyl acetate esterase, leukocyte count, and the presence of extramedullary disease at presentation. Two myeloid antigens (MY4 and MY7) predicted for a low rate of complete remission (CR) to standard induction chemotherapy. MY4+ cases (37% of the total population) had a CR rate of 53%, while M4- cases had a CR rate of 69% (P = .03). MY7+ cases (57% of the total population) had a CR rate of 55% while MY7- cases had a CR rate of 73% (P = .01). Neither MY4 nor MY7 antigen expression was correlated with patient age. Paired combinations of antigens were also examined. The [MY4- MY7-] phenotype was exhibited by 32% of all cases and was associated with an 82% CR rate while the CR rate of all other cases was 54% (P = .001). The expression of three antigens (HLA-DR, MY8, Mo1) was associated with a decreased continuous complete remission (P less than .05, median follow-up time of 19 months). Expression of MY8 antigen was also associated with decreased survival (P = .03). These results confirm earlier reports of antigenic heterogeneity in AML, and indicate that immunologically defined subgroups of AML patients which are of potential clinical significance can be identified.

Clinical significance of presence and extent of extrapancreatic necrosis in acute pancreatitis

2015 ◽  
Vol 30 (4) ◽  
pp. 794-798 ◽  
Author(s):  
Surinder S Rana ◽  
Vishal Sharma ◽  
Ravi K Sharma ◽  
Puneet Chhabra ◽  
Rajesh Gupta ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Significance

scholarly journals Analysis of Monocytic and Granulocytic Myeloid-Derived Suppressor Cells Subsets in Patients with Hepatitis C Virus Infection and Their Clinical Significance

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gang Ning ◽  
Lanhui She ◽  
Lirong Lu ◽  
Ying Liu ◽  
Yingfu Zeng ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Suppressor Cells ◽  
Hcv Rna ◽  
Myeloid Derived Suppressor Cells ◽  
Hepatitis C Virus Infection ◽  
Cell Responses ◽  
Hla Dr ◽  
Healthy Donors

Myeloid-derived suppressor cells (MDSCs) have been shown to inhibit T-cell responses in many diseases, but, in hepatitis C virus (HCV) infected patients, MDSCs are still poorly studied. In this assay, we investigated the phenotype and frequency of two new populations of MDSCs denoted as monocytic and granulocytic MDSCs (M-MDSCs and G-MDSCs) in HCV infected patients and analyzed their clinical significance in these patients respectively. We found that the frequency of CD14+HLA-DR-/lowcells (M-MDSCs) from HCV infected patients (mean ± SE, 3.134% ± 0.340%) was significantly increased when compared to healthy controls (mean ± SE, 1.764% ± 0.461%) (Z= −2.438,P= 0.015), while there was no statistical difference between the frequency ofHLA-DR-/lowCD33+CD11b+CD15+(G-MDSCs) of HCV infected patients and healthy donors (0.201% ± 0.038% versus 0.096% ± 0.026%,P> 0.05), which suggested that HCV infection could cause the proliferation of M-MDSCs instead of G-MDSCs. Besides, we found that the frequency of M-MDSCs in HCV infected patients had certain relevance with age (r= 0.358,P= 0.003); patients older than 40 years old group (mean ± SE, 3.673% ± 0.456%) had a significantly higher frequency of M-MDSCs than that of age less than 40 years old group (mean ± SE, 2.363% ± 0.482%) (Z= −2.685,P= 0.007). The frequency of M-MDSCs, however, had no correlation with HCV RNA loads, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the level of liver inflammation degree.

scholarly journals CD64 Expression Is Increased in Patients with Severe Acute Pancreatitis: Clinical Significance

Gut and Liver ◽  
2014 ◽  
Vol 8 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Hao Zhang ◽  
Xian-Long Ling ◽  
Yu-Yun Wu ◽  
Mu-Han Lü ◽  
Hong Guo ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Significance ◽  
Severe Acute Pancreatitis ◽  
Cd64 Expression
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