Exocrine pancreatic insufficiency in patients with pancreatic or peri-ampullary cancer: A systematic review

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S43 ◽  
Author(s):  
Dorine S.J. Tseng ◽  
C. Hjalmar ◽  
van Santvoort ◽  
H.M. Inne ◽  
Borel Rinkes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pancreatic Insufficiency ◽  
Ampullary Cancer ◽  
Exocrine Pancreatic Insufficiency

Exocrine pancreatic insufficiency following acute pancreatitis: Systematic review and meta-analysis

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S102
Author(s):  
Daniel De la Iglesia-García ◽  
Wei Huang ◽  
Iria Baston-Rey ◽  
Cristina Calviño-Suarez ◽  
Jose Lariño-Noia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Pancreatitis ◽  
Meta Analysis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency

scholarly journals Systematic Review of Exocrine Pancreatic Insufficiency after Gastrectomy for Cancer

2017 ◽  
Vol 34 (5) ◽  
pp. 364-370 ◽  
Author(s):  
Jennifer Straatman ◽  
Jim Wiegel ◽  
Nicole van der Wielen ◽  
E.P. Jansma ◽  
Miguel A. Cuesta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency

scholarly journals Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus: do we need to treat it? A systematic review

Pancreatology ◽  
2018 ◽  
Vol 18 (5) ◽  
pp. 559-565 ◽  
Author(s):  
Gábor Zsóri ◽  
Dóra Illés ◽  
Viktória Terzin ◽  
Emese Ivány ◽  
László Czakó
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency

scholarly journals Exocrine pancreatic insufficiency in type 1 and type 2 diabetesmellitus: do we need to treat it? A systematic review

2019 ◽  
Vol 42 (1) ◽  
pp. 18-29
Author(s):  
G. Zsóri ◽  
D. Illés ◽  
V. Terzin ◽  
L. Czakó
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Diabetic Patients ◽  
Enzyme Replacement ◽  
Advantages And Disadvantages ◽  
Patients With Diabetes

The exocrine and endocrine pancreata are very closely linked both anatomically and physiologically. Abdominal symptoms such as nausea, bloating, diarrhea, steatorrhea, and weight loss can often occur in diabetic patients. Impairments of the exocrine pancreatic function seem to be a frequent complication of diabetes mellitus; however, they are largely overlooked. The aim of this paper is to provide an overview of the current concepts of exocrine pancreatic insufficiency (PEI) in diabetes mellitus. This systematic review provides information on the high prevalence of chronic pancreatic diseases in patients with diabetes; statements that reveal the multifactorial mechanism of PEI development upon violation of glucose uptake are summarized. The main PEI clinical manifestations in diabetes are described, the difficulties of timely detection of EPN are considered, the advantages and disadvantages of the “gold standards” of laboratory diagnostics (determination of the level of fecal elastase 1 and the coefficient of fat absorption, respiratory test using mixed triglycerides, 13C labeled, and secretin-pancreozymin test) in this cohort of patients. The data of randomized researches that studied the effectiveness of enzyme replacement therapy of PEI in patients with diabetes are analyzed. The ability of enzyme replacement therapy to normalize digestion has been confirmed, and its possible effect on glycemia and vitamin D levels in patients with diabetes and EPN has been considered. The reasons for the continuation of taking enzyme preparations are listed.

scholarly journals The Role of Sphere Size in the Context of Pancreatin Therapy for Exocrine Pancreatic Insufficiency: A Systematic Review

2021 ◽  
Author(s):  
Karl-Uwe Petersen ◽  
Malfertheiner Peter ◽  
Mössner Joachim
Keyword(s):  
Systematic Review ◽  
Gastric Emptying ◽  
Scientific Evidence ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Current Guideline ◽  
Sphere Size ◽  
Enteric Coated ◽  
The Individual

While lipase content and appropriate acid protection of pancreatin preparations (PP) are well defined determinants of an effective therapy of exocrine pancreatic insufficiency, the optimal sphere size of PP has remained a matter of discussion. We performed a systematic review to assess the optimal sphere size of enteric coated pancreatin products that may best guarantee coordinated delivery of PP and food to the duodenum. PubMed was searched for studies on gastric emptying of indigestible spheres in the digestive phase, using overlapping search algorithms; identified sources were searched for further leads, extending the investigation to Google Scholar. Of 739 screened publications, 26 were included in the final assessment. Contrary to current guideline recommendations, no scientific evidence was found to support a 2 mm diameter threshold for gastric emptying of indigestible particles. There is no documented advantage of ≤2 mm spheres regarding duodenal delivery and restoring maldigestion. The evolving picture is that of a gradation of sizes, over which gastric emptying becomes slower and more variable as particle size increases. Even 7 mm particles may be emptied from the stomach in conjunction with nutrient uptake. In conclusion sphere size of PP is not the essential parameter for selecting an effective PP fitting all patients. A variety of brands offer different lipase contents and sphere sizes that allow the physician to tailor treatment to the individual patient`s needs.

Tu1457 Diagnostic Utility of Fecal Elastase-1 in Exocrine Pancreatic Insufficiency - A Systematic Review and Meta-Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S906
Author(s):  
Rohini R. Vanga ◽  
Aylin Tansel ◽  
Avinash G. Ketwaroo ◽  
Hashem B. El-Serag ◽  
Mohamed O. Othman
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Diagnostic Utility ◽  
Fecal Elastase ◽  
Elastase 1
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