Pancreatic cancer metastasis: Mutual regulation of cancer- and stroma-derived matrix metalloproteinases

Pancreatology ◽  
2013 ◽  
Vol 13 (2) ◽  
pp. e29-e30
Author(s):  
H. Habisch ◽  
S. Zhou ◽  
M. Siech ◽  
T. Seufferlein ◽  
M. Bachem
Keyword(s):  
Pancreatic Cancer ◽  
Matrix Metalloproteinases ◽  
Cancer Metastasis ◽  
Mutual Regulation

Pancreatic cancer metastasis: High MMP7 expression promotes mutual activation of cancer- and stroma-derived matrix metalloproteinases

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S60
Author(s):  
Hansjörg Habisch ◽  
Shaoxia Zhou ◽  
Marco Siech ◽  
Thomas Seufferlein ◽  
Max Bachem
Keyword(s):  
Pancreatic Cancer ◽  
Matrix Metalloproteinases ◽  
Cancer Metastasis

MicroRNA-34b Inhibits Pancreatic Cancer Metastasis Through Repressing Smad3

2013 ◽  
Vol 13 (4) ◽  
pp. 467-478 ◽  
Author(s):  
C. Liu ◽  
H. Cheng ◽  
S. Shi ◽  
X. Cui ◽  
J. Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Metastasis

Roles of Fyn in pancreatic cancer metastasis

2010 ◽  
Vol 25 (2) ◽  
pp. 293-301 ◽  
Author(s):  
Zhi-Yu Chen ◽  
Lei Cai ◽  
Ping Bie ◽  
Shu-Guang Wang ◽  
Yan Jiang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Metastasis

scholarly journals Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo

2014 ◽  
Vol 87 (2) ◽  
pp. 142-149 ◽  
Author(s):  
Muayad Almahariq ◽  
Celia Chao ◽  
Fang C. Mei ◽  
Mark R. Hellmich ◽  
Igor Patrikeev ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Metastasis ◽  
Pharmacological Inhibition ◽  
Exchange Protein

scholarly journals High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Bo Ren ◽  
Jinshou Yang ◽  
Chengcheng Wang ◽  
Gang Yang ◽  
Huanyu Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Resolution ◽  
Cancer Biology ◽  
Poor Prognosis ◽  
Cancer Metastasis ◽  
Metastatic Pancreatic Cancer ◽  
Loop Formation ◽  
Pancreatic Cancer Cells ◽  
Pancreatic Epithelium ◽  
Upregulated Genes

Abstract Background Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. Methods Here, we developed high-resolution 3D epigenomic maps of cells derived from normal pancreatic epithelium, primary and metastatic pancreatic cancer by in situ Hi-C, ChIP-seq, ATAC-seq, and RNA-seq to identify key genes involved in pancreatic cancer metastasis Results We found that A/B compartments, contact domains, and chromatin loops changed significantly in metastatic pancreatic cancer cells, which are associated with epigenetic state alterations. Moreover, we found that upregulated genes, which were located in switched compartments, changed contact domains, and metastasis-specific enhancer-promoter loops, were related to cancer metastasis and poor prognosis of patients with pancreatic cancer. We also found that transcription factors in specific enhancer-promoter loop formation were also associated with metastasis. Finally we demonstrated that LIPC, looped to metastasis-specific enhancers, could promote pancreatic cancer metastasis. Conclusions These results highlight the multiscale 3D epigenome reprogramming during pancreatic cancer metastasis and expand our knowledge of mechanisms of gene regulation during pancreatic cancer metastasis.

scholarly journals MicroRNA-23a promotes pancreatic cancer metastasis by targeting epithelial splicing regulator protein 1

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 82854-82871 ◽  
Author(s):  
Guo Wu ◽  
Zhonghu Li ◽  
Peng Jiang ◽  
Xi Zhang ◽  
Yingqiang Xu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Metastasis ◽  
Regulator Protein ◽  
Splicing Regulator

scholarly journals Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 61674-61686 ◽  
Author(s):  
Huan Liu ◽  
Le Li ◽  
Hua Chen ◽  
Rui Kong ◽  
Shangha Pan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Metastasis ◽  
Chemotherapeutic Sensitivity
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