The prognostic influence of resection margin clearance following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma

Pancreatology ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. e15-e16
Author(s):  
Nigel B. Jamieson ◽  
Nigel I.J. Chan ◽  
Alan K. Foulis ◽  
Euan J. Dickson ◽  
Colin J. McKay ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Ductal Adenocarcinoma

scholarly journals Clinical impacts of resection margin status and clinicopathologic parameters on pancreatic ductal adenocarcinoma

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Tsengelmaa Jamiyan ◽  
Takayuki Shiraki ◽  
Yoshihiro Kurata ◽  
Masanori Ichinose ◽  
Keiichi Kubota ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Margin Status ◽  
Ductal Adenocarcinoma ◽  
Resection Margin Status ◽  
Clinicopathologic Parameters

The Prognostic Influence of Resection Margin Clearance Following Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma

2013 ◽  
Vol 17 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Nigel B. Jamieson ◽  
Nigel I. J. Chan ◽  
Alan K. Foulis ◽  
Euan J. Dickson ◽  
Colin J. McKay ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Ductal Adenocarcinoma

Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma

2012 ◽  
Vol 16 (10) ◽  
pp. 1875-1882 ◽  
Author(s):  
Yaojun Zhang ◽  
Adam E. Frampton ◽  
Patrizia Cohen ◽  
Charis Kyriakides ◽  
Jan J. Bong ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Ductal Adenocarcinoma ◽  
Tumor Infiltration

817 The Prognostic Influence of Resection Margin Clearance Following Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma

2012 ◽  
Vol 142 (5) ◽  
pp. S-1043
Author(s):  
Nigel B. Jamieson ◽  
Nigel Chan ◽  
Euan J. Dickson ◽  
Colin McKay ◽  
Ross Carter
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Ductal Adenocarcinoma

scholarly journals Prospective Evaluation of Resection Margins Using Standardized Specimen Protocol Analysis among Patients with Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

2021 ◽  
Vol 10 (15) ◽  
pp. 3247
Author(s):  
Jonathan Garnier ◽  
Jacques Ewald ◽  
Flora Poizat ◽  
Eddy Traversari ◽  
Ugo Marchese ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Protocol Analysis ◽  
Neoadjuvant Treatment ◽  
Ductal Adenocarcinoma ◽  
Resection Margins ◽  
Resection Rate ◽  
Venous Resection ◽  
Distal Cholangiocarcinoma ◽  
R1 Resection

Purpose: Using a standardized specimen protocol analysis, this study aimed to evaluate the resection margin status of patients who underwent resection for either distal cholangiocarcinoma (DC) or pancreatic ductal adenocarcinoma (PDAC). This allowed a precise millimetric analysis of each inked margin. Methods: From 2010 to 2018, 355 consecutively inked specimens from patients with PDAC (n = 288) or DC (n = 67) were prospectively assessed. We assessed relationships between the tumor and the following margins: transection of the pancreatic neck, bile duct, posterior surface, margin toward superior mesenteric artery, and the surface of superior mesenteric vein/portal vein groove. Resection margins were evaluated using a predefined cut-off value of 1 mm; however, clearances of 0 and 1.5 mm were also evaluated. Results: Patients with DC were mostly men (64% vs. 49%, p = 0.028), of older age (68 yo vs. 65, p = 0.033), required biliary stenting more frequently (93% vs. 77%, p < 0.01), and received less neoadjuvant treatment (p < 0.001) than patients with PDAC. The venous resection rate was higher among patients with PDAC (p = 0.028). Postoperative and 90-day mortality rates were comparable. Patients with PDAC had greater tumor size (28.6 vs. 24 mm, p = 0.01) than those with DC. The R1 resection rate was comparable between the two groups, regardless of the clearance margin. Among the three types of resection margins, a venous groove was the most frequent in both entities. In multivariate analysis, the R1 resection margin did not influence patient survival in either PDAC or DC. Conclusion: Our standardized specimen protocol analysis showed that the R1 resection rate was comparable in PDAC and DC.

scholarly journals Which Factors Are Associated with Positive Resection Margin in Pancreatic Ductal Adenocarcinoma for different surgical procedures? Results Based on a Standard Pathological Evaluation System-Retrospective Cohort Study

2021 ◽  
Author(s):  
Bo Li ◽  
Shiwei Guo ◽  
Xiaohan Shi ◽  
Chenming Ni ◽  
Suizhi Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Resection Margin ◽  
Tnm Staging ◽  
Ductal Adenocarcinoma ◽  
Pathological Examination ◽  
Multivariate Logistic Regression ◽  
R1 Resection ◽  
Independent Risk Factors

Abstract Background/Objectives: The present study identified the independent risk factors of R1 resection in pancreaticoduodenectomy (PD) and distal pancreatosplenectomy (DP) for patients with pancreatic ductal adenocarcinoma (PDAC).Methods：Consecutive patients who were operated from 1st December 2017 to 30th December 2018 with curative intent were analyzed retrospectively. A standardized pathological examination with digital whole-mount slide images (DWMSIs) was utilized for the resection margin status. R1 was defined as microscopic tumor infiltration within 1 mm to the resection margin. The potential risk factors of R1 resection for PD and DP were analyzed separately by univariate and multivariate logistic regression analyses. Results：For the 240 patients who underwent PD, and the 146 patients who underwent DP, the R1 resection rates were 30.8% and 35.6 %, respectively. Univariate analysis on risk factors of R1 resection for PD were tumor location, absence of tumor necrosis, N staging, and TNM staging; while those for DP were perineural invasion, T staging, and TNM staging. Multivariate logistic regression analysis showed the location of tumor in the neck and uncinate process, and N1/2 staging were independent risk factors of R1 resection for PD; while those for DP were T3/4 staging. Conclusions：The clarification of the risk factors of R1 resection might clearly make surgeons take better decisions on surgical strategies for different surgical precedures in patients with PDAC.

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