Potential non–immunoglobulin E–mediated food allergies: Comparison of open challenge and double-blind placebo-controlled food challenge

2007 ◽  
Vol 137 (5) ◽  
pp. 803-809 ◽  
Author(s):  
De Yun Wang ◽  
Bruce R. Gordon ◽  
Yiong Huak Chan ◽  
Kian Hian Yeoh
Keyword(s):  
Immunoglobulin E ◽  
Food Challenge ◽  
Food Allergies ◽  
Double Blind ◽  
Double Blind Placebo

Allergy To Shrimp: A Double Blind, Placebo-controlled, Food Challenge Study And Allergens Implicated In Spain.

2009 ◽  
Vol 123 (2) ◽  
pp. S23-S23 ◽  
Author(s):  
S. Sanchez-Garcia ◽  
C. Gamez ◽  
E. Lopez ◽  
M.D. Ibañez ◽  
C. Escudero ◽  
...  
Keyword(s):  
Food Challenge ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Challenge Study

Double-blind, placebo-controlled food challenge with apple

Allergy ◽  
2001 ◽  
Vol 56 (2) ◽  
pp. 109-117 ◽  
Author(s):  
K. Skamstrup Hansen ◽  
H. Vestergaard ◽  
P. Stahl Skov ◽  
M. Sondergaard Khinchi ◽  
S. Vieths ◽  
...  
Keyword(s):  
Food Challenge ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Eliciting dose is associated with tolerance development in peanut and cow’s milk allergic children

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
C. Nitsche ◽  
C. D. Westerlaken-van Ginkel ◽  
B. J. Kollen ◽  
A. B. Sprikkelman ◽  
G. H. Koppelman ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Food Challenge ◽  
Specific Ige ◽  
Food Allergies ◽  
Milk Allergy ◽  
Egg Allergy ◽  
Tolerance Development ◽  
Double Blind ◽  
Gold Standard Method

Abstract Background Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little is known about the association of the eliciting dose (ED) obtained during the initial DBPCFC with later tolerance development. Methods This was a retrospective, tertiary care study of children who had a positive DBPCFC to either peanut, milk or egg, and at least one follow-up food challenge (open or DBPCFC) with the same food. The association between ED and negative (tolerant) follow-up food challenge outcome was analyzed by logistic regression, with adjustment for confounders. Suspected confounders were initial DBPCFC test characteristics, atopic comorbidities and serum specific IgE (sIgE) levels. Results In 47 peanut allergic children, tolerance developed in 27.7% (median follow-up duration of 43 months). In 80 milk (follow-up 23 months) and 55 egg (follow-up 37 months) allergic children, tolerance developed in 55.0% and 65.5%. The ED obtained during the initial DBPCFC was significantly associated with tolerance development in peanut and milk allergy, but not in egg allergy. Conclusion Approximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC.

Nahrungsmittelprovokationen im Kindesalter ganz praktisch

2018 ◽  
Vol 44 (08/09) ◽  
pp. 360-365
Author(s):  
M. Ziegert ◽  
V. Trendelenburg
Keyword(s):  
Food Challenge ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Klinische Relevanz

ZusammenfassungIm Säuglings- und Kleinkindalter gehören IgE-vermittelte Nahrungsmittelallergien zu den häufigsten allergischen Erkrankungen. Insbesondere die orale Nahrungsmittelprovokation stellt hier einen Grundpfeiler einer fundierten Diagnostik dar. Der Goldstandard ist die doppelblinde, Placebo-kontrollierte Nahrungsmittelprovokation (DBPCFC; double-blind, placebo-controlled food challenge). Sie hilft, v. a. bei unklarer Anamnese, die klinische Relevanz einer Sensibilisierung gegen Nahrungsmittel zu überprüfen oder neu zu evaluieren. Im Säuglings- und Kleinkindalter ist eine genaue Diagnostik besonders relevant, um unnötig einschränkende Eliminationsdiäten zu vermeiden oder den Patienten bzw. deren Eltern hinsichtlich einer individuell angepassten spezifischen Ernährungstherapie zu beraten. Dieser Artikel beschreibt praktische Vorgehensweisen für die Durchführung oraler Nahrungsmittelprovokationen im Kindesalter mit Fokus auf die am häufigsten vorkommenden IgE-vermittelten Nahrungsmittelallergien (Kuhmilch, Hühnerei, Erdnuss).

scholarly journals Double-blind, Placebo-controlled Food Challenge Is Essential In Primary Hazelnut Allergy Diagnosis

2020 ◽  
Vol 145 (2) ◽  
pp. AB230
Author(s):  
Danbing Ke ◽  
Bruce Mazer ◽  
Duncan Lejtenyi ◽  
Liane Beaudette ◽  
Yvan St-Pierre ◽  
...  
Keyword(s):  
Food Challenge ◽  
Allergy Diagnosis ◽  
Double Blind ◽  
Double Blind Placebo

Masking foods for food challenge: Practical aspects of masking foods for a double-blind, placebo-controlled food challenge

1994 ◽  
Vol 94 (6) ◽  
pp. 645-649 ◽  
Author(s):  
Geertje B Huijbers ◽  
Ann A.M Colen ◽  
Jeannette J Niestijl Jansen ◽  
Alwine F.M Kardinaal ◽  
Berber J Vlieg-Boerstra ◽  
...  
Keyword(s):  
Food Challenge ◽  
Double Blind ◽  
Double Blind Placebo
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