Cost-Utility of Anti–Vascular Endothelial Growth Factor Treatment for Macular Edema Secondary to Central Retinal Vein Occlusion

2020 ◽  
Author(s):  
James Lin ◽  
Allister Gibbons ◽  
William E. Smiddy
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Macular Edema ◽  
Central Retinal Vein Occlusion ◽  
Cost Utility ◽  
Vascular Endothelial ◽  
Vein Occlusion ◽  
Endothelial Growth Factor ◽  
Central Retinal Vein ◽  
Growth Factor Treatment

Cotton Wool Spots after Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Associated with Central Retinal Vein Occlusion

2016 ◽  
Vol 235 (2) ◽  
pp. 106-113 ◽  
Author(s):  
Teruyo Kida ◽  
Akitaka Tsujikawa ◽  
Yuki Muraoka ◽  
Seiyo Harino ◽  
Rie Osaka ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Macular Edema ◽  
Central Retinal Vein Occlusion ◽  
Vascular Endothelial ◽  
Cotton Wool ◽  
Cotton Wool Spots ◽  
Vein Occlusion ◽  
Endothelial Growth Factor ◽  
Central Retinal Vein

Purpose: To report a case series, whereby we encountered a transient increase in retinal cotton wool spots (CWS) following anti-vascular endothelial growth factor (anti-VEGF) therapy for the treatment of macular edema secondary to central retinal vein occlusion (CRVO). Methods: Eighteen eyes were treated with intravitreal aflibercept (IVA), and 5 were treated with intravitreal ranibizumab (IVR). Fundus photographs obtained 1 month after initial IVA or IVR injections were retrospectively evaluated for the presence of CWS. Results: Twenty-one (91.3%) patients had the following systemic diseases: hypertension, diabetes mellitus without retinopathy, dyslipidemia, or chronic renal failure requiring dialysis. One month after treatment, reduced macular edema was observed in 21 (91.3%) eyes. Initial injections facilitated complete resolution in 14 eyes, and CWS gradually became fainter with additional injections. Conclusion: Some eyes with CRVO-related macular edema can show a transient increase in CWS after initial anti-VEGF therapy; however, macular edema, retinal hemorrhage, and visual acuity were improved in almost every case.

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