Atypical Retinal Lamination Pattern Associated with Bilateral Chorioretinal Coloboma

2018 ◽  
Vol 2 (3) ◽  
pp. 256-257
Author(s):  
Parker J. Williams ◽  
Robert A. Prinzi ◽  
Joshua Robinson ◽  
Nieraj Jain
Keyword(s):  
Retinal Lamination

scholarly journals Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

Neuron ◽  
2011 ◽  
Vol 71 (3) ◽  
pp. 460-473 ◽  
Author(s):  
Ryota L. Matsuoka ◽  
Onanong Chivatakarn ◽  
Tudor C. Badea ◽  
Ivy S. Samuels ◽  
Hugh Cahill ◽  
...  
Keyword(s):  
And Function ◽  
Retinal Lamination

Optical Coherence Tomography in Enhanced S-Cone Syndrome: Large Macular Retinoschisis with Disorganized Retinal Lamination

2005 ◽  
Vol 15 (5) ◽  
pp. 643-646 ◽  
Author(s):  
T. Hayashi ◽  
K. Kitahara
Keyword(s):  
Optical Coherence Tomography ◽  
Outer Nuclear Layer ◽  
Plexiform Layer ◽  
Retinal Layer ◽  
Temporal Region ◽  
Optical Coherence ◽  
Macular Retinoschisis ◽  
Molecular Features ◽  
Enhanced S Cone Syndrome ◽  
Retinal Lamination

Purpose The authors previously reported clinical and molecular features of a boy (at age 17) with enhanced S-cone syndrome (ESCS) who had bilateral cystoid maculopathies. The purpose of the current study was to describe the patient's optical coherence tomography (OCT) findings. Methods OCT was performed when the patient was 23 years old. Results OCT images revealed formations of single large hyporeflective cystic spaces in the cystoid maculopathies of both eyes. The cystic spaces were much larger than those of previously reported cases. In the temporal region of each cystic space, symmetric disorganized retinal lamination was observed with the retina lacking well-defined and hypoeflective bands of the inner nuclear layer and the outer nuclear layer, which are seen in normal retina. Splitting in the retinal thickness was at the level of the outer retinal layer rather than at the inner retinal layer in both eyes. Conclusions Splitting is likely to occur close to the outer plexiform layer in which the cleavage plane of familial juvenile retinoschisis is identified. The unique OCT manifestation of symmetric large macular retinoschisis with disorganized retinal lamination may indicate a severe form of ESCS.

scholarly journals Knockdown of Zebrafish Blood Vessel Epicardial Substance Results in Incomplete Retinal Lamination

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Yu-Ching Wu ◽  
Ruei-Feng Chen ◽  
Chia-Yang Liu ◽  
Fung Rong Hu ◽  
Chang-Jen Huang ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Cell Polarity ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Photoreceptor Cells ◽  
Transgenic Zebrafish ◽  
Inner Plexiform Layer ◽  
Cellular Polarity ◽  
Apical Junctions ◽  
Retinal Lamination

Cell polarity during eye development determines the normal retinal lamination and differentiation of photoreceptor cells in the retina. In vertebrates, blood vessel epicardial substance (Bves) is known to play an important role in the formation and maintenance of the tight junctions essential for epithelial cell polarity. In the current study, we generated a transgenic zebrafish Bves (zbves) promoter-EGFP zebrafish line to investigate the expression pattern of Bves in the retina and to study the role ofzbvesin retinal lamination. Immunostaining with different specific antibodies from retinal cells and transmission electron microscopy were used to identify the morphological defects in normal and Bves knockdown zebrafish. In normal zebrafish, Bves is located at the apical junctions of embryonic retinal neuroepithelia during retinogenesis; later, it is strongly expressed around inner plexiform layer (IPL) and retinal pigment epithelium (RPE). In contrast, a loss of normal retinal lamination and cellular polarity was found with undifferentiated photoreceptor cells in Bves knockdown zebrafish. Herein, our results indicated that disruption of Bves will result in a loss of normal retinal lamination.

scholarly journals Essential role of α6 integrins in cortical and retinal lamination

1998 ◽  
Vol 8 (17) ◽  
pp. 983-S1 ◽  
Author(s):  
Elisabeth Georges-Labouesse ◽  
Manuel Mark ◽  
Nadia Messaddeq ◽  
Anne Gansmüller
Keyword(s):  
Essential Role ◽  
Retinal Lamination

scholarly journals The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination

2004 ◽  
Vol 269 (1) ◽  
pp. 286-301 ◽  
Author(s):  
Xiangyun Wei ◽  
Yan Cheng ◽  
Yiying Luo ◽  
Xiaohai Shi ◽  
Scott Nelson ◽  
...  
Keyword(s):  
Retinal Lamination

scholarly journals nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system

2010 ◽  
Vol 344 (2) ◽  
pp. 784-794 ◽  
Author(s):  
Andrew J. Pittman ◽  
John A. Gaynes ◽  
Chi-Bin Chien
Keyword(s):  
Axon Guidance ◽  
Retinotectal System ◽  
Retinal Lamination
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