Analysing surface plasmon resonance phase sensor based on Mach-Zehnder interferometer technique using glycerin

2016 ◽  
Vol 380 ◽  
pp. 419-424 ◽  
Author(s):  
Muhammad Kashif ◽  
A. Ashrif A. Bakar ◽  
Fazida Hanim Hashim
Author(s):  
Zahra Akbarpour ◽  
Vahid Ahmadi ◽  
Farzaneh Arabpour Roghabadi

In this paper, an all-fiber Mach-Zehnder interferometer (MZI) sensor for refractive index (RI) measuring is presented, which is based on Multimode–Single-mode–Multimode (MSM) fiber. The effects of both reducing the radius of the sensing part and the surface plasmon resonance (SPR) on its efficiency are investigated. Increasing the interaction of high-order modes with external media, caused by etching the cladding layer of the single-mode fiber part, significantly improves the sensitivity. Both wavelength and intensity interrogation approaches are employed to study the Multimode–etched Single-mode–Multimode (MESM) fiber sensor. The intensity and the wavelength sensitivities for the RI measurement in the range of 1.428-1.458 are obtained as -2308.92 %/RIU and 1313.14 nm/RIU, respectively. Finally, the MESM-SPR sensor is proposed and characterized. Results exhibit high performance in the RI range of 1.333 to 1.357, in which the sensitivity of 1433 nm/RIU is achieved. The advantages like low cost, high sensitivity, and simple fabrication methods make these sensors promising devices for chemical, food industry, and biosensing applications.


2006 ◽  
Author(s):  
H. P. Ho ◽  
C. L. Wong ◽  
K. F. Lei ◽  
W. J. Li ◽  
C. Lin ◽  
...  

2020 ◽  
pp. 44-49
Author(s):  
I. N. Pavlov

Two optical methods, namely surface plasmon resonance imaging and frustrated total internal reflection, are described in the paper in terms of comparing their sensitivity to change of refractive index of a thin boundary layer of an investigated medium. It is shown that, despite the fact that the theoretically calculated sensitivity is higher for the frustrated total internal reflection method, and the fact that usually in practice the surface plasmon resonance method, on the contrary, is considered more sensitive, under the same experimental conditions both methods show a similar result.


2010 ◽  
Vol 130 (7) ◽  
pp. 269-274 ◽  
Author(s):  
Takeshi Onodera ◽  
Takuzo Shimizu ◽  
Norio Miura ◽  
Kiyoshi Matsumoto ◽  
Kiyoshi Toko

PIERS Online ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 746-750 ◽  
Author(s):  
Bing-Hung Chen ◽  
Yih-Chau Wang ◽  
Jia-Hng Lin

2018 ◽  
Author(s):  
Yong Cao ◽  
Mark T. McDermott

<div> <div> <div> <p>Quantitative measurement of small-molecule metabolites is now emerging as an effective way to link the metabolite profile to disease state. Surface plasmon resonance (SPR) is a sensing platform that has demonstrated applicability for a large range of biomolecules. However, direct detection of small molecules with SPR challenges the refractive index based detection mechanism. Herein, we utilized an indirect detection format and developed an inhibition immunoassay for the quantitative measurement of 17β-estradiol (E2) using SPR. One competitor, BSA-E2 conjugate, was immobilized to the SPR chip via the reaction between the primary amino group of the conjugate and the succinimide group (NHS) introduced by the formation of a thiol-NHS monolayer on gold surface. Free E2 molecules compete with BSA-E2 on chip surface for binding sites provided by a monoclonal anti-E2 antibody. It was found the binding affinity of the antibody to BSA-E2 conjugate increases with decreasing surface coverage of BSA-E2 conjugate. Under optimal conditions, a sigmoidal calibration curve with a negative slope and a dynamic range from 10 pM to 2 nM was generated. The detection limit of the immunoassay is estimated to be 0.3 pM. Moreover, the immunoassay exhibits high specificity for E2 detection using estrone (E1) as a potential interference.</p></div></div></div>


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