P3.74. Quantification of betel quid chewing and cigarette smoking in oral cancer patients

2009 ◽  
Vol 3 (1) ◽  
pp. 226
Author(s):  
K.-Y. Tsai ◽  
C.-C. Su ◽  
I.-B. Lian
Keyword(s):  
Oral Cancer ◽  
Cigarette Smoking ◽  
Cancer Patients ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients

Quantification of betel quid chewing and cigarette smoking in oral cancer patients

2009 ◽  
Vol 37 (6) ◽  
pp. 555-561 ◽  
Author(s):  
Kuo-Yang Tsai ◽  
Che-Chun Su ◽  
Yo-Yu Lin ◽  
Jian-An Chung ◽  
Ie-Bin Lian
Keyword(s):  
Oral Cancer ◽  
Cigarette Smoking ◽  
Cancer Patients ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients

scholarly journals Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history

1999 ◽  
Vol 20 (12) ◽  
pp. 2331-2334 ◽  
Author(s):  
Chiu-Lan Chen ◽  
Chin-Wen Chi ◽  
Kuo-Wei Chang ◽  
Tsung-Yun Liu
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Dna Adducts ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients ◽  
Oral Tissue

The mRNA profile of genes in betel quid chewing oral cancer patients

Oral Oncology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 418-426 ◽  
Author(s):  
Wan-Chi Tsai ◽  
Sen-Tien Tsai ◽  
Jenq-Yuh Ko ◽  
Ying-Tai Jin ◽  
Ching Li ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients ◽  
Mrna Profile

scholarly journals Effect of MACC1 Genetic Polymorphisms and Environmental Risk Factors in the Occurrence of Oral Squamous Cell Carcinoma

2021 ◽  
Vol 11 (6) ◽  
pp. 490
Author(s):  
Rei-Hsing Hu ◽  
Chun-Yi Chuang ◽  
Chiao-Wen Lin ◽  
Shih-Chi Su ◽  
Lun-Ching Chang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Environmental Risk ◽  
Clinicopathological Characteristics ◽  
Environmental Risk Factors ◽  
Betel Quid ◽  
Nucleotide Polymorphisms ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients

MACC1 (Metastasis Associated in Colon Cancer 1) is found to regulate the hepatocyte growth factor (HGF)/Met signal pathway, and plays an important role in tumor proliferation, angiogenesis, and metastasis. However, the relationships between MACC1 SNPs (single nucleotide polymorphisms) and oral cancer are still blurred. In this study, five SNPs (rs3095007, rs1990172, rs4721888, rs975263, and rs3735615) were genotyped in 911 oral cancer patients and 1200 healthy individuals by real-time polymerase chain reaction (PCR), and the associations of oral cancer with the SNP genotypes, environmental risk factors, and clinicopathological characteristics were further analyzed. Our results showed that individuals who had GC genotype or C-allele (GC + CC) in rs4721888 would have a higher risk for oral cancer incidence than GG genotype after adjustment for betel quid chewing, cigarette smoking, and alcohol drinking. Moreover, the 715 oral cancer patients with a betel quid chewing habit, who had C-allele (TC + CC) in rs975263, would have a higher risk for lymph node metastasis. Further analyses of the sequences of rs4721888 revealed that the C-allele of rs4721888 would be a putative exonic splicing enhancer. In conclusion, MACC1 SNP rs4721888 would elevate the susceptibility for oral cancer, and SNP rs975263 would increase the metastasis risk for oral cancer patients with a betel quid chewing habit. Our data suggest that SNP rs4721888 could be a putative genetic marker for oral cancer, and SNP rs975362 may have the potential to be a prognostic marker of metastasis in an oral cancer patient.

scholarly journals Acrolein is involved in the synergistic potential of cigarette smoking- and betel quid chewing-related human oral cancer.

2019 ◽  
pp. cebp.1033.2018 ◽  
Author(s):  
Hsiang-Tsui Wang ◽  
Han-Hsing Tsou ◽  
Chih-Hung Hu ◽  
Jin-Hui Liu ◽  
Chung-Ji Liu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cigarette Smoking ◽  
Betel Quid ◽  
Betel Quid Chewing

Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan

1995 ◽  
Vol 24 (10) ◽  
pp. 450-453 ◽  
Author(s):  
Ying-Chin Ko ◽  
Yung-Li Huang ◽  
Chien-Hung Lee ◽  
Mei-Ju Chen ◽  
Li-Min Lin ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Oral Cancer ◽  
Cigarette Smoking ◽  
Betel Quid ◽  
Betel Quid Chewing

scholarly journals Qualitative study for betel quid cessation among oral cancer patients

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199503 ◽  
Author(s):  
Chen-Yi Lee ◽  
Chih-Feng Wu ◽  
Chun-Ming Chen ◽  
Yong-Yuan Chang
Keyword(s):  
Oral Cancer ◽  
Qualitative Study ◽  
Cancer Patients ◽  
Betel Quid ◽  
Oral Cancer Patients

scholarly journals Determining Potential Target Groups for Oral Cancer Screening by Investigating Risk Behaviors Among Occupations

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 49s-49s
Author(s):  
Y.-T. Huang ◽  
Y.-W. Wang ◽  
R.-C. Chen ◽  
C.-Y. Wu ◽  
Y.-H. Yang
Keyword(s):  
Cluster Analysis ◽  
Cancer Screening ◽  
Oral Cancer ◽  
Cigarette Smoking ◽  
Screening Program ◽  
Smoking Habits ◽  
Betel Quid ◽  
High Prevalence ◽  
Betel Quid Chewing ◽  
Oral Cancer Screening

Background: Oral cancer is a major public health burden in Taiwan. Studies have suggested that habits of betel quid chewing, tobacco smoking and alcohol drinking as well as their interaction effects are important risk factors for oral cancer and oral potentially malignant disorders (OPMD). A population-based oral cancer screening program has been implemented by Health Promotion Administration, Ministry of Health and Welfare, Taiwan. People with betel quid chewing and/or cigarette smoking habits are recommended for biennially screening. Previous studies found that majority of betel quid chewers were in labor intensive occupations. Given the fact that high risk groups of oral cancer are often reluctant to attend screening, targeted approach should be applied to improve the effectiveness of screening program. Aim: The aims of this study are to identify occupations with high prevalence of betel-quid chewing and also to investigate changing trends using the National Health Interview Survey (NHIS) database. Methods: The NHIS database of 2009 and 2013 were used to conduct this study. We identified current users of betel quid and/or cigarette from adults with aged 20-64 years old and working on jobs. Occupations were classified using the International Standard Classification of Occupations (ISCO-88). Statistical analyses included indirect standardized rate ratios and cluster analysis of chewing/smoking habits. Results: From the total survey participants (2009: 19,201, 2013: 17,249), we extracted 11,507 and 10,760 persons for the study. In the year of 2013, using the 2-digit code of ISCO-88, drivers and mobile-plant operators (code 83 in ISCO-88) had the highest prevalence of betel quid chewing habit (30.9%), followed by extraction and building trades workers (code 71 in ISCO-88, 29.6%). These two groups also had the 2 highest smoking prevalence (61.2% and 62.2%). The betel quid chewing prevalence decreased from 2009 to 2013 slightly (32.3%-30.9%). However, the prevalence of smoking increased (60.0%-62.2%). Among the betel quid chewers of the two focused occupations, the corresponding rates of receiving oral cancer screening were rather low (35.47% and 21.52%). The indirect standardized ratios using the total sample as the reference showed 6 occupations (2 digit of ISCO-88) with significantly higher ratios (larger than 2). Cluster analysis demonstrated that the group with high prevalence of betel quid chewing also had high prevalence of cigarette smoking habit. Conclusion: The betel quid chewing prevalence has been decreased in all occupations. While at the same time, prevalence of cigarette smoking did not largely decrease. We analyzed the NHIS databases and found that workers in some occupations tend to have higher prevalence in both betel quid chewing and smoking. The oral cancer screening and cancer awareness need be targeted on certain occupations.

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