P3.31. Role of GSK-3β as a negative regulator of epithelial-mesenchymal transition in oral cancer cells

2009 ◽  
Vol 3 (1) ◽  
pp. 210-211
Author(s):  
J.H. Kang ◽  
J.J. Joung ◽  
J.B. Cho ◽  
P.Y. Yun ◽  
J.H. Lee ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Negative Regulator ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells ◽  
Gsk 3Β

scholarly journals DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells

Cell Reports ◽  
2017 ◽  
Vol 20 (1) ◽  
pp. 61-75 ◽  
Author(s):  
Adone Mohd-Sarip ◽  
Miriam Teeuwssen ◽  
Alice G. Bot ◽  
Maria J. De Herdt ◽  
Stefan M. Willems ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

scholarly journals Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade

2020 ◽  
Author(s):  
Yuichi Ohnishi ◽  
Tsukasa Sakamoto ◽  
Li Zhengguang ◽  
Hiroki Yasui ◽  
Hiroyuki Hamada ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

scholarly journals MicroRNA-133 Targets Phosphodiesterase 1C in Drosophila and Human Oral Cancer Cells to Regulate Epithelial-Mesenchymal Transition

2021 ◽  
Vol 12 (17) ◽  
pp. 5296-5309
Author(s):  
Ji Eun Jung ◽  
Joo Young Lee ◽  
Hae Ryoun Park ◽  
Ji Wan Kang ◽  
Yun Hak Kim ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

Combination of celecoxib and calyculin-A inhibits epithelial-mesenchymal transition in human oral cancer cells

2020 ◽  
Vol 95 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Bharath Kumar Velmurugan ◽  
Chun-Hung Hua ◽  
Ming-Hsui Tsai ◽  
Chi-Pin Lee ◽  
Chia-Min Chung ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Calyculin A ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

scholarly journals EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 9557-9571 ◽  
Author(s):  
Qilin Xu ◽  
Qunzhou Zhang ◽  
Yasutaka Ishida ◽  
Souren Hajjar ◽  
Xudong Tang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

scholarly journals PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial–Mesenchymal Transition

2021 ◽  
Vol 22 (9) ◽  
pp. 5012
Author(s):  
V. Bharath Kumar ◽  
Jen-Tsun Lin ◽  
B. Mahalakshmi ◽  
Yi-Ching Chuang ◽  
Hsin-Yu Ho ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mapk Pathway ◽  
Cathepsin L ◽  
Mapk Signaling ◽  
Cancer Prognosis ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells

Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe sideeffects. In the present study, we studied the efficacy of a diarylheptanoid derivative, platyphyllenone, in modulating the metastatic potential of human oral cancer cells. Specifically, we treated the human oral cancer cells (FaDu, Ca9-22, and HSC3) with different concentrations of platyphyllenone and measured the cell proliferation, migration, and invasion. The study findings revealed that platyphyllenonesignificantly inhibited the motility, migration, and invasion of human oral cancer cells. Mechanistically, platyphyllenone reduced p38 phosphorylation, decreased β-catenin and Slug, increased E-cadherin expression, and reduced cathepsin L expression, which collectively led to a reduction in cancer cell migration and invasion. Taken together, our study indicates that platyphyllenone exerts significant anti-metastatic effects on oral cancer cells by modulating cathepsin L expression, the MAPK signaling pathway, and the epithelial–mesenchymal transition process.

scholarly journals Exosome mediated miR-155 delivery confers cisplatin chemoresistance in oral cancer cells via epithelial-mesenchymal transition

Oncotarget ◽  
2020 ◽  
Vol 11 (13) ◽  
pp. 1157-1171 ◽  
Author(s):  
Prathibha Kirave ◽  
Piyush Gondaliya ◽  
Bhagyashri Kulkarni ◽  
Rakesh Rawal ◽  
Rachana Garg ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Oral Cancer Cells ◽  
Cisplatin Chemoresistance
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