O191. Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV and a favorable prognosis

2009 ◽  
Vol 3 (1) ◽  
pp. 119-120 ◽  
Author(s):  
J.J. Mooren ◽  
A.H.N. Hopman ◽  
F.C.S. Ramaekers ◽  
J.J. Manni ◽  
B. Kremer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chromosome Stability ◽  
Favorable Prognosis ◽  
Tonsillar Squamous Cell Carcinoma

scholarly journals Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis

2012 ◽  
Vol 132 (8) ◽  
pp. 1781-1789 ◽  
Author(s):  
Jeroen J. Mooren ◽  
Bernd Kremer ◽  
Sandra M.H. Claessen ◽  
Adri C. Voogd ◽  
Fredrik J. Bot ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chromosome Stability ◽  
Favorable Prognosis ◽  
Tonsillar Squamous Cell Carcinoma

Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma

2021 ◽  
Vol 43 (4) ◽  
pp. 371-378
Author(s):  
Can Cao ◽  
Chao Zhang ◽  
Ying Sun ◽  
Zhen Mu ◽  
Qin Shen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Favorable Prognosis

Transoral resection of tonsillar squamous cell carcinoma

2009 ◽  
Vol 119 (3) ◽  
pp. 508-515 ◽  
Author(s):  
Eric J. Moore ◽  
Doug K. Henstrom ◽  
Kerry D. Olsen ◽  
Jan L. Kasperbauer ◽  
Michaela E. McGree
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Resection ◽  
Tonsillar Squamous Cell Carcinoma

scholarly journals Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Cristina Saiz-Ladera ◽  
Mariona Baliu-Piqué ◽  
Francisco J. Cimas ◽  
Aránzazu Manzano ◽  
Vanesa García-Barberán ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Immune System ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Immune Effector ◽  
Effector Cells ◽  
Favorable Prognosis ◽  
Immune Effector Cells ◽  
Tumor Types

Targeting the immune system has emerged as an effective therapeutic strategy for the treatment of various tumor types, including Head and Neck Squamous Cell Carcinoma (HNSCC) and Non-small-Cell Lung Cancer (NSCLC), and checkpoint inhibitors have shown to improve patient survival in these tumor types. Unfortunately, not all cancers respond to these agents, making it necessary to identify responsive tumors. Several biomarkers of response have been described and clinically tested. As of yet what seems to be clear is that a pre-activation state of the immune system is necessary for these agents to be efficient. In this study, using established transcriptomic signatures, we identified a group of gene combination associated with favorable outcome in HNSCC linked to a higher presence of immune effector cells. CD2, CD3D, CD3E, and CXCR6 combined gene expression is associated with improved outcome of HNSCC patients and an increase of infiltrating immune effector cells. This new signature also identifies a subset of cervical squamous cell carcinoma (CSCC) patients with favorable prognosis, who show an increased presence of immune effector cells in the tumor, which outcome shows similarities with the HP-positive HNSCC cohort of patients. In addition, CD2, CD3D, CD3E, and CXCR6 signature is able to predict the best favorable prognosis in terms of overall survival of CSSC patients. Of note, these findings were not reproduced in other squamous cell carcinomas like esophageal SCC or lung SCC. Prospective confirmatory studies should be employed to validate these findings.

scholarly journals Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass

2019 ◽  
Vol 7 ◽  
pp. 232470961984290
Author(s):  
Prabhjot Bhinder ◽  
Michael Chahin ◽  
Lara Zuberi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Chronic Lymphocytic Leukemia ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Mass ◽  
Lymphocytic Leukemia ◽  
Secondary Malignancies ◽  
Increased Risk ◽  
History Of ◽  
Tonsillar Squamous Cell Carcinoma

Chronic lymphocytic leukemia (CLL) patients are at an increased risk for developing more aggressive lymphomas via Richter’s transformation and of developing secondary malignancies. Despite the known association for secondary cancers, oropharyngeal cancers occur rarely. We present a case of a woman with a history of CLL who presented to our facility via transfer for impending airway compromise. Her initial workup was consistent with CLL; however, biopsies were taken of the neck mass because of its aggressive nature. She was treated with rituximab with good response. Final pathology showed evidence of CLL and tonsillar squamous cell carcinoma (SCC). Direct laryngoscopy and further biopsies yielded a diagnosis of unresectable oropharyngeal SCC. She was to be treated with chemotherapy and radiation for her SCC while holding treatment for CLL. This case demonstrates a rare and unexpected concurrent diagnosis.

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