scholarly journals STRATIfiCATION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA USING COMBINED ANALYSIS OF PROGRAMMED DEATH LIGAND 1 AND SEMAPHORIN 4D EXPRESSION BY THE INflAMMATORY CELLS IN THE TUMOR MICROENVIRONMENT

2019 ◽  
Vol 128 (1) ◽  
pp. e80
Author(s):  
Dr. Rania Younis ◽  
Dr. Sonia Sanadhya ◽  
Dr. Ioana Ghita ◽  
Dr. Ingy H. Elkomary ◽  
Dr. Haiyan Chen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Inflammatory Cells ◽  
Programmed Death Ligand 1 ◽  
Combined Analysis ◽  
Semaphorin 4D ◽  
Programmed Death

scholarly journals Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 908
Author(s):  
Masaharu Hazawa ◽  
Hironori Yoshino ◽  
Yuta Nakagawa ◽  
Reina Shimizume ◽  
Keisuke Nitta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Ionizing Radiation ◽  
Cell Surface ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Transport Receptors

Nuclear transport receptors, such as karyopherin-β1 (KPNB1), play important roles in the nuclear-cytoplasmic transport of macromolecules. Recent evidence indicates the involvement of nuclear transport receptors in the progression of cancer, making these receptors promising targets for the treatment of cancer. Here, we investigated the anticancer effects of KPNB1 blockage or in combination with ionizing radiation on human head and neck squamous cell carcinoma (HNSCC). HNSCC cell line SAS and Ca9-22 cells were used in this study. Importazole, an inhibitor of KPNB1, or knockdown of KPNB1 by siRNA transfection were applied for the blockage of KPNB1 functions. The roles of KPNB1 on apoptosis induction and cell surface expression levels of programmed death-ligand 1 (PD-L1) in irradiated HNSCC cells were investigated. The major findings of this study are that (i) blockage of KPNB1 specifically enhanced the radiation-induced apoptosis and radiosensitivity of HNSCC cells; (ii) importazole elevated p53-upregulated modulator of apoptosis (PUMA) expression via blocking the nuclear import of SCC-specific oncogene ΔNp63 in HNSCC cells; and (iii) blockage of KPNB1 attenuated the upregulation of cell surface PD-L1 expression on irradiated HNSCC cells. Taken together, these results suggest that co-treatment with KPNB1 blockage and ionizing radiation is a promising strategy for the treatment of HNSCC.

scholarly journals Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (58) ◽  
pp. 97920-97927 ◽  
Author(s):  
Chan-Young Ock ◽  
Sehui Kim ◽  
Bhumsuk Keam ◽  
Soyeon Kim ◽  
Yong-Oon Ahn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals The Role of the Programmed Death Receptor-1/Programmed Death Ligand-1: Immunologic Checkpoint in Human Papillomavirus–Associated Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 142 (6) ◽  
pp. 719-720
Author(s):  
Christine Kunkle ◽  
Flavia G Rosado
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Death Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

Context.— There has been increasing interest in understanding the role of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway in cancer biology and its clinical significance in cancer therapy. Objective.— To discuss the studies of the PD-1/PD-L1 pathway in human papillomavirus–positive head and neck squamous cell carcinoma, focusing on the pathogenesis of cancer, characterization of the tumor microenvironment, and the effect of such studies in laboratory medicine. Data sources.— Data sources included peer-reviewed literature and reputable online sources. Conclusions.— To date, there are few studies of PD-1 and PD-L1 in human papillomavirus–positive head and neck squamous cell carcinoma. There is evidence that the PD-1/PD-L1 pathway has a role in this type of cancer; however, further studies are needed to better characterize the effect of the human papillomavirus and its use as a marker of therapy response.

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